scholarly journals Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA

2018 ◽  
Vol 43 (6) ◽  
pp. 369-375 ◽  
Author(s):  
Norie Murayama ◽  
Hiroshi Suemizu ◽  
Shotaro Uehara ◽  
Takashi Kusama ◽  
Marina Mitsui ◽  
...  
1978 ◽  
Vol 6 (5) ◽  
pp. 446P-447P ◽  
Author(s):  
HE Barber ◽  
GM Hawksworth ◽  
NR Kitteringham ◽  
J Petersen ◽  
JC Petrie ◽  
...  

1981 ◽  
Vol 196 (3) ◽  
pp. 693-698 ◽  
Author(s):  
A A Lamola ◽  
I Asher ◽  
U Muller-Eberhard ◽  
M Poh-Fitzpatrick

Fluorescence spectra of protoporphyrin bound to its most affinitive site on human serum albumin, bound to human haemopexin and dissolved in human plasma reveal that, when present in plasma, at least 90% of this porphyrin is bound to albumin. Human serum albumin binds protoporphyrin with an affinity KA = 3 } 10(9)M-1 in phosphate-buffered saline. The affinity of haemopexin for protoporphyrin is 4 times smaller. From these data it is concluded that less than 1% of plasma protoporphyrin is bound to haemopexin. Implications of the data for protoporphyrin transport and clearance are discussed.


2006 ◽  
Vol 27 (12) ◽  
pp. 1637-1641 ◽  
Author(s):  
Rafal KALITYNSKI ◽  
Andrzej L DAWIDOWICZ ◽  
Jacek POSZYTEK

2019 ◽  
Vol 29 (1) ◽  
pp. 51-53 ◽  
Author(s):  
L Moreno Lozano ◽  
P Galindo Bonilla ◽  
J Borja Segade ◽  
A Extremera Ortega ◽  
E Gómez Torrijos ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document