scholarly journals Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis

2012 ◽  
Vol 37 (6) ◽  
pp. 1127-1134 ◽  
Author(s):  
Katsunori Yamaura ◽  
Ryosuke Doi ◽  
Eriko Suwa ◽  
Koichi Ueno
Keyword(s):  
Contact Dermatitis ◽  
Mast Cells ◽  
Allergic Contact Dermatitis ◽  
Murine Model ◽  
Prostaglandin D2 ◽  
Repeated Application ◽  
Allergic Contact

scholarly journals Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis

2017 ◽  
Vol 118 (1) ◽  
pp. 619-624 ◽  
Author(s):  
Lintao Qu ◽  
Kai Fu ◽  
Steven G. Shimada ◽  
Robert H. LaMotte
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Murine Model ◽  
Behavioral Effects ◽  
Contact Hypersensitivity ◽  
Squaric Acid ◽  
Neuronal Activation ◽  
Ionic Mechanisms ◽  
Cxcr3 Signaling ◽  
Allergic Contact

Persistent itch often accompanies allergic contact dermatitis (ACD), but the underlying mechanisms remain largely unexplored. We previously demonstrated that CXCL10/CXCR3 signaling activated a subpopulation of cutaneous primary sensory neurons and mediated itch response after contact hypersensitivity (CHS), a murine model of ACD, induced by squaric acid dibutylester. The purpose of this study was to determine the ionic mechanisms underlying CXCL10-induced neuronal activation and allergic itch. In whole cell recordings, CXCL10 triggered a current in dorsal root ganglion (DRG) neurons innervating the area of CHS. This current was modulated by intracellular Cl− and blocked by the general Cl− channel inhibitors. Moreover, increasing Ca2+ buffering capacity reduced this current. In addition, blockade of Cl− channels significantly suppressed CXCL10-induced Ca2+ response. In behavioral tests, injection of CXCL10 into CHS site exacerbated itch-related scratching behaviors. Moreover, the potentiating behavioral effects of CXCL10 were attenuated by either of two Cl− channel blockers. Thus we suggest that the Cl− channel acts as a downstream target mediating the excitatory and pruritic behavioral effects of CXCL10. Cl− channels may provide a promising therapeutic target for the treatment of allergic itch in which CXCL10/CXCR3 signaling may participate. NEW & NOTEWORTHY The ionic mechanisms underlying CXCL10-induced neuronal activation and allergic itch are largely unexplored. This study revealed that CXCL10 evoked an ionic current mainly carried by Cl− channels. We suggest that Cl− channels are likely key molecular candidates responsible for the CXCL10-evoked neuronal activation and itch-like behaviors in a murine model of allergic contact dermatitis induced by the antigen squaric acid dibutylester. Cl− channels may emerge as a promising drug target for the treatment of allergic itch in which CXCL10/CXCR3 signaling may participate.

scholarly journals Spinal GRPR and NPRA Contribute to Chronic Itch in a Murine Model of Allergic Contact Dermatitis

2020 ◽  
Vol 140 (9) ◽  
pp. 1856-1866.e7 ◽  
Author(s):  
Xueting Liu ◽  
De Wang ◽  
Yuhuan Wen ◽  
Liping Zeng ◽  
Yangyang Li ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Murine Model ◽  
Chronic Itch ◽  
Allergic Contact

scholarly journals Accumulation of Metal-Specific T Cells in Inflamed Skin in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85983 ◽  
Author(s):  
Hiroaki Shigematsu ◽  
Kenichi Kumagai ◽  
Hiroshi Kobayashi ◽  
Takanori Eguchi ◽  
Kazutaka Kitaura ◽  
...  
Keyword(s):  
T Cells ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Murine Model ◽  
Allergic Contact

scholarly journals Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis

2013 ◽  
Vol 9 (33) ◽  
pp. 9 ◽  
Author(s):  
Katsunori Yamaura ◽  
Ayana Tomono ◽  
Eriko Suwa ◽  
Koichi Ueno
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Murine Model ◽  
Royal Jelly ◽  
Allergic Contact

scholarly journals Accumulation of metal-specific T cells in inflamed skin in a novel murine model of Chromium-induced allergic contact dermatitis

2014 ◽  
Vol 72 (9) ◽  
pp. e180-e181
Author(s):  
H. Shigematsu ◽  
K. Kumagai ◽  
H. Kobayashi ◽  
T. Eguchi ◽  
T. Nagaoka ◽  
...  
Keyword(s):  
T Cells ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Murine Model ◽  
Allergic Contact

New aspect of allergic contact dermatitis, an inflammatory skin disorder mediated by mast cells: Can IL-38 help?

2020 ◽  
Vol 139 ◽  
pp. 109687 ◽  
Author(s):  
Dorita Lauritano ◽  
Gianpaolo Ronconi ◽  
Alessandro Caraffa ◽  
Carla Enrica Gallenga ◽  
Spyros K. Kritas ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Mast Cells ◽  
Allergic Contact Dermatitis ◽  
Skin Disorder ◽  
Inflammatory Skin Disorder ◽  
Inflammatory Skin ◽  
Allergic Contact
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