scholarly journals A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells

2010 ◽  
Vol 35 (4) ◽  
pp. 515-525 ◽  
Author(s):  
Yuichiro Kanno ◽  
Yoshio Inouye
Keyword(s):  
Hepg2 Cells ◽  
Insertion Mutant ◽  
Screening System ◽  
Alanine Residue ◽  
Ligand Screening

scholarly journals Development of a Novel PPARγ Ligand Screening System Using Pinpoint Fluorescence-Probed Protein

2011 ◽  
Vol 75 (2) ◽  
pp. 337-341 ◽  
Author(s):  
Hiroyuki NAGAI ◽  
Shogo EBISU ◽  
Ryoji ABE ◽  
Tsuyoshi GOTO ◽  
Nobuyuki TAKAHASHI ◽  
...  
Keyword(s):  
Screening System ◽  
Ligand Screening

scholarly journals Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line

2018 ◽  
Vol 293 (26) ◽  
pp. 10333-10343 ◽  
Author(s):  
Keisuke Tachibana ◽  
Tomohiro Yuzuriha ◽  
Ryotaro Tabata ◽  
Syohei Fukuda ◽  
Takashi Maegawa ◽  
...  
Keyword(s):  
Cell Line ◽  
Peroxisome Proliferator ◽  
Screening System ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ligand Screening

Novel PPARγ partial agonists with weak activity and no cytotoxicity; identified by a simple PPARγ ligand screening system

2011 ◽  
Vol 358 (1-2) ◽  
pp. 75-83 ◽  
Author(s):  
Min-Chul Cho ◽  
Dong-Hun Lee ◽  
Eun Jin Kim ◽  
Jee-young Lee ◽  
Jeong-Woo Kang ◽  
...  
Keyword(s):  
Screening System ◽  
Partial Agonists ◽  
Ligand Screening ◽  
Weak Activity

Development of a Cell-Based Ligand-Screening System for Identifying Hsp90 Inhibitors

Biochemistry ◽  
2019 ◽  
Vol 59 (2) ◽  
pp. 179-182 ◽  
Author(s):  
Tsuyoshi Ueda ◽  
Tomonori Tamura ◽  
Itaru Hamachi
Keyword(s):  
Screening System ◽  
Hsp90 Inhibitors ◽  
Ligand Screening ◽  
A Cell

scholarly journals Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity

2021 ◽  
Author(s):  
Na Yeon Park ◽  
Doo Sin Jo ◽  
Yong Hwan Kim ◽  
Ji-Eun Bae ◽  
Joon Bum Kim ◽  
...  
Keyword(s):  
Cell Viability ◽  
Cell Fate ◽  
Hepg2 Cells ◽  
Screening System ◽  
Autophagy Flux ◽  
Screening Process ◽  
Autophagic Degradation ◽  
A Cell ◽  
Cellular Organelles

AbstractThe maintenance of lysosomal integrity is essential for lysosome function and cell fate. Damaged lysosomes are degraded by lysosomal autophagy, lysophagy. The mechanism underlying lysophagy remains largely unknown; this study aimed to contribute to the understanding of this topic. A cell-based screening system was used to identify novel lysophagy modulators. Triamterene (6-phenylpteridine-2,4,7-triamine) was identified as one of the most potent lysophagy inducers from the screening process. We found that triamterene causes lysosomal rupture without affecting other cellular organelles and increases autophagy flux in HepG2 cells. Damaged lysosomes in triamterene-treated cells were removed by autophagy-mediated pathway, which was inhibited by depletion of the autophagy regulator, ATG5 or SQSTM1. In addition, treatment of triamterene decreased the integrity of lysosome and cell viability, which were rescued by removing the triamterene treatment in HepG2 cells. Hence, our data suggest that triamterene is a novel lysophagy inducer through the disruption of lysosomal integrity.

Mental health screening system using intranet setting in a company.

1999 ◽  
Author(s):  
Minoru Arai ◽  
Daisuke Mori ◽  
Tetsu Kawamura ◽  
Hideo Fumimoto ◽  
Masagi Shimazaki ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Screening ◽  
Mental Health Screening ◽  
Screening System ◽  
A Company

Glucagon induziert eine signifikante nukleäre Translokation von FOXO1, nachgewiesen mit einem neu entwickelten, hochsensitiven, GFP-FOXO1 basierten screening System

2010 ◽  
Vol 5 (S 01) ◽  
Author(s):  
C Bumke-Vogt ◽  
A Arafat ◽  
M Osterhoff ◽  
H Elkatry ◽  
A Ziegenhorn ◽  
...  
Keyword(s):  
Screening System
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