scholarly journals Systemic toxicity of non-cell corynebacterium parvum (CP) in monkeys

2010 ◽  
Vol 35 (3) ◽  
pp. 279-286
Author(s):  
Bao-qiu Li ◽  
Xin Dong ◽  
Shi-hong Fang ◽  
Gui-qin Yang ◽  
Ji-you Gao ◽  
...  
Keyword(s):  
Systemic Toxicity ◽  
Corynebacterium Parvum

TOXIC EFFECTS ASSESSMENT OF NICKEL OXIDE NANOPARTICLES BY INHALATION

2018 ◽  
pp. 24-29 ◽  
Author(s):  
B.A. Katsnelson ◽  
M.P. Sutunkova ◽  
L.I. Privalova ◽  
S.N. Solovjeva ◽  
V.B. Gurvich ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Redox Balance ◽  
Systemic Toxicity ◽  
Laboratory Animals ◽  
Oxide Nanoparticles ◽  
Nickel Oxide Nanoparticles ◽  
White Rats ◽  
Liver And Kidney ◽  
Stimulation Of Erythropoiesis ◽  
Nio Nps

The article presents in an experiment obtained principal results based on repeated low-level inhalation exposures of laboratory animals (white rats, outbred) to nickel oxide nanoparticles with a diameter of (23 ± 5) nm, 4 hours a day, 5 times a week for up to 10 months in a «nose only» installation. It was shown that non-specific body reactions to the action of NiO NPs include: diverse manifestations of systemic toxicity with a particularly pronounced influence on liver and kidney function, redox balance, damage to some areas of brain tissue, associated with proven movement of the nanoparticles themselves from the nasal mucosa along the olfactory tract; some cytological signs of probable development for allergic syndrome; paradoxically low severity of pulmonary pathology by pneumoconiotic type explained by a small chronic delay of nanoparticles in the lungs; the genotoxic effect of the organismal level, even at those low levels of chronic exposure, at which systemic toxicity is rather poorly. Along with that, NiO NPs also induce phase-stimulation of erythropoiesis, which is relatively specific for the toxic nickel effects.

Updates in our understanding of local anaesthetic systemic toxicity: a narrative review

Anaesthesia ◽  
2021 ◽  
Vol 76 (S1) ◽  
pp. 27-39
Author(s):  
A. J. R. Macfarlane ◽  
M. Gitman ◽  
K. J. Bornstein ◽  
K. El‐Boghdadly ◽  
G. Weinberg
Keyword(s):  
Local Anaesthetic ◽  
Systemic Toxicity ◽  
Narrative Review

Epithelial dendritic cells and connective tissue macrophages in oral corcinogenesis and the effects of systemic Corynebacterium parvum

1989 ◽  
Vol 10 (3) ◽  
pp. 501-507 ◽  
Author(s):  
A. Pitigala-Arachchi ◽  
J.B. Matthews ◽  
C. Scully ◽  
S.S. Prime
Keyword(s):  
Dendritic Cells ◽  
Connective Tissue ◽  
Corynebacterium Parvum

The importance of parasite load in the killing ofPlasmodium vinckeiin mice treated withCorynebacterium parvumor alloxan monohydrate

Parasitology ◽  
1984 ◽  
Vol 89 (3) ◽  
pp. 417-424 ◽  
Author(s):  
F. E. G. Cox ◽  
Stephanie M. Millott
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Parasite Load ◽  
Corynebacterium Parvum ◽  
Specific Immunity ◽  
Pre Treatment ◽  
Alloxan Monohydrate ◽  
High Parasitaemias ◽  
Plasmodium Vinckei

SUMMARYMice pre-treated withCorynebacterium parvumand later challenged withPlasmodium vinckeibecome infected but do not die whereas control mice do. When pre-treated mice were challenged with 1, 10, 1 × 102, 1 × 104, 1 × 105or 1 × 106parasites, the pre-patent periods correlated directly with the number of parasites injected, but the subsequent parasitaemias reached similar levels. This suggests that parasite killing, resulting from pre-treatment withC. parvum, is not triggered until the parasite load has reached a particular threshold. The injection of alloxan monohydrate, which brings about the release of toxic oxygen inter mediates thought to be involved in non-specific immunity, has little effect onP. vinckeiinfections until the parasitaemia is relatively high. This indicates that oxygen-mediated parasite killing also does not occur until the parasitaemia has reached a particular threshold. It is suggested that it is only at relatively high parasitaemias that the factors involved in parasite killing are able to enter the infected red blood cells.

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