scholarly journals EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES - EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE

2007 ◽  
Vol 32 (3) ◽  
pp. 205-215 ◽  
Author(s):  
Toshinori YAMAMOTO ◽  
Kaori TOMIZAWA ◽  
Masaaki FUJIKAWA ◽  
Yasushi SATO ◽  
Hiroshi YAMADA ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Human Hepatocyte ◽  
Chimeric Mice ◽  
Toxicological Investigation ◽  
Endogenous Metabolites ◽  
Human Hepatocyte Chimeric Mice

scholarly journals Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

2019 ◽  
Vol 54 (7) ◽  
pp. 650-659 ◽  
Author(s):  
Ken Tsushima ◽  
Masataka Tsuge ◽  
Nobuhiko Hiraga ◽  
Takuro Uchida ◽  
Eisuke Murakami ◽  
...  
Keyword(s):  
Human Hepatocyte ◽  
Chimeric Mice ◽  
Hbv Genotype ◽  
Human Hepatocyte Chimeric Mice ◽  
Genotype A

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

2011 ◽  
Vol 54 (5) ◽  
pp. 872-878 ◽  
Author(s):  
Eiji Ohara ◽  
Nobuhiko Hiraga ◽  
Michio Imamura ◽  
Eiji Iwao ◽  
Naohiro Kamiya ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Human Hepatocyte ◽  
Chimeric Mice ◽  
Short Term ◽  
Inhibitor Combination ◽  
Human Hepatocyte Chimeric Mice

scholarly journals Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice

2009 ◽  
Vol 51 (6) ◽  
pp. 1046-1054 ◽  
Author(s):  
Nobuhiko Hiraga ◽  
Michio Imamura ◽  
Tsuyoshi Hatakeyama ◽  
Shosuke Kitamura ◽  
Fukiko Mitsui ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Hepatocyte ◽  
Chimeric Mice ◽  
Viral Interference ◽  
B Virus ◽  
Human Hepatocyte Chimeric Mice

scholarly journals Effects of Hepatitis B Virus Infection on the Interferon Response in Immunodeficient Human Hepatocyte Chimeric Mice

2011 ◽  
Vol 204 (2) ◽  
pp. 224-228 ◽  
Author(s):  
Masataka Tsuge ◽  
Shoichi Takahashi ◽  
Nobuhiko Hiraga ◽  
Yoshifumi Fujimoto ◽  
Yizhou Zhang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Human Hepatocyte ◽  
Interferon Response ◽  
Hepatitis B Virus Infection ◽  
Chimeric Mice ◽  
B Virus ◽  
Human Hepatocyte Chimeric Mice

Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice

2015 ◽  
Vol 21 (4) ◽  
pp. 307-315 ◽  
Author(s):  
Hiromi Kan ◽  
Nobuhiko Hiraga ◽  
Michio Imamura ◽  
C Nelson Hayes ◽  
Takuro Uchida ◽  
...  
Keyword(s):  
Human Hepatocyte ◽  
Combination Therapies ◽  
Chimeric Mice ◽  
Human Hepatocyte Chimeric Mice

scholarly journals HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice

2010 ◽  
Vol 91 (7) ◽  
pp. 1854-1864 ◽  
Author(s):  
M. Tsuge ◽  
N. Hiraga ◽  
R. Akiyama ◽  
S. Tanaka ◽  
M. Matsushita ◽  
...  
Keyword(s):  
Human Hepatocyte ◽  
Chimeric Mice ◽  
Human Hepatocyte Chimeric Mice

scholarly journals Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice

Gut ◽  
2013 ◽  
Vol 62 (7) ◽  
pp. 1055-1061 ◽  
Author(s):  
Niu Shi ◽  
Nobuhiko Hiraga ◽  
Michio Imamura ◽  
C Nelson Hayes ◽  
Yizhou Zhang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Hepatocyte ◽  
Combination Therapies ◽  
Chimeric Mice ◽  
Human Hepatocyte Chimeric Mice
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