scholarly journals Hormonal disregulation mechanism in the rat thyroid tumor induced by diniconazole.

1993 ◽  
Vol 18 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Shunji HOSOKAWA ◽  
Jun NAKAMURA ◽  
Seiichi ITO ◽  
Masakazu MURAKAMI ◽  
Mariko INEYAMA ◽  
...  
Keyword(s):  
Thyroid Tumor ◽  
Rat Thyroid

scholarly journals Effects of sex hormones and PTU on growth of transplantable rat thyroid tumor with estrogen receptor (ER).

1992 ◽  
Vol 95 (2) ◽  
pp. 201-206
Author(s):  
KATSUNARI YANE ◽  
OSAMU TANAKA ◽  
HIROSHI MIYAHARA ◽  
TAKASHI MATSUNAGA ◽  
YOSHITERU KITAHORI ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Sex Hormones ◽  
Thyroid Tumor ◽  
Rat Thyroid

Characterization of Abnormal Thyroglobulin in a Transplantable Rat Thyroid Tumor

Endocrinology ◽  
1977 ◽  
Vol 100 (5) ◽  
pp. 1448-1460 ◽  
Author(s):  
M IZUMI ◽  
H.J. CAHNMANN ◽  
J. ROBBINS
Keyword(s):  
Thyroid Tumor ◽  
Rat Thyroid

Incorporation of Carbohydrates into Abnormal Thyroglobulin in an Experimental Rat Thyroid Tumor

Endocrinology ◽  
1974 ◽  
Vol 94 (5) ◽  
pp. 1445-1450 ◽  
Author(s):  
F. MONACO ◽  
M. D'ARMIENTO ◽  
J. ROBBINS
Keyword(s):  
Thyroid Tumor ◽  
Rat Thyroid

Studies on a Cell Line from a Functional Rat Thyroid Tumor in Continuous Culture

Endocrinology ◽  
1976 ◽  
Vol 99 (2) ◽  
pp. 549-554 ◽  
Author(s):  
RAUL CAVIEDES ◽  
JOHN B. STANBURY
Keyword(s):  
Continuous Culture ◽  
Cell Line ◽  
Thyroid Tumor ◽  
A Cell ◽  
Rat Thyroid

scholarly journals Defective Thyroglobulin Synthesis in an Experimental Rat Thyroid Tumor

1973 ◽  
Vol 248 (7) ◽  
pp. 2328-2336 ◽  
Author(s):  
Fabrizio Monaco ◽  
Jacob Robbins
Keyword(s):  
Thyroid Tumor ◽  
Rat Thyroid

scholarly journals FOXO1 Controls Thyroid Cell Proliferation in Response to TSH and IGF-I and Is Involved in Thyroid Tumorigenesis

2013 ◽  
Vol 27 (1) ◽  
pp. 50-62 ◽  
Author(s):  
Miguel A. Zaballos ◽  
Pilar Santisteban
Keyword(s):  
Cell Proliferation ◽  
Tumor Cells ◽  
Thyroid Tumor ◽  
Human Thyroid ◽  
Thyroid Cell ◽  
Dependent Manner ◽  
Thyroid Cells ◽  
Differentiated Cells ◽  
Igf I ◽  
Rat Thyroid

TSH and insulin/IGF-I synergistically induce the proliferation of thyroid cells mainly through the cAMP and phosphatidylinositol 3-kinase (PI3K) pathways. However, the events involved in this cooperative induction remain unknown, and molecules that are potentially controlled by both TSH and IGF-I are interesting candidates as integrators of both stimuli. The finding that the PI3K pathway is frequently activated in thyroid malignancies has attracted attention to this pathway in the thyroid field. One of the targets of PI3K is Forkhead box O (FoxO)-1, a widely expressed transcription factor involved in a variety of cellular processes such as differentiation, proliferation, and apoptosis. Here we show that FoxO1 is highly expressed in differentiated rat thyroid cells and human thyroid tissue compared with human thyroid tumor-derived cells and surgically removed thyroid tumors, in which its expression is reduced. In differentiated cells, TSH/cAMP treatment decreases FoxO1 mRNA and protein levels through proteasome activation, whereas both TSH and IGF-I control FoxO1 localization by promoting a rapid exclusion from the nucleus in an Akt-dependent manner. FoxO1 can control p27KIP1 expression in differentiated and tumor cells of the thyroid. Furthermore, FoxO1 reexpression in tumor cells promotes a decrease in their proliferation rate, whereas FoxO1 interference in differentiated cells increases their proliferation. These data point to an important role of FoxO1 in mediating the effects of TSH and IGF-I on thyroid cell proliferation and provide a link between loss of FoxO1 expression and the uncontrolled proliferation of thyroid tumor cells.

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