scholarly journals Effects of various inducers on the activities of cytochrome P-450-mixed function oxidases and aflatoxin B1 activation in microsomes of hamster livers.

1988 ◽  
Vol 13 (4) ◽  
pp. 193-204 ◽  
Author(s):  
Momoko SUNOUCHI ◽  
Morio FUKUHARA ◽  
Yasuo OHNO ◽  
Akira TAKANAKA
Keyword(s):  
Aflatoxin B1 ◽  
Mixed Function Oxidases ◽  
Cytochrome P 450

Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B1

Toxicology ◽  
2002 ◽  
Vol 172 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Hala A Awney ◽  
Ahmed M Attih ◽  
Sami L Habib ◽  
Mostafa H Mostafa
Keyword(s):  
Hydrogen Peroxide ◽  
Aflatoxin B1 ◽  
Cytochrome P 450

scholarly journals Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver.

1990 ◽  
Vol 87 (21) ◽  
pp. 8306-8310 ◽  
Author(s):  
L. M. Forrester ◽  
G. E. Neal ◽  
D. J. Judah ◽  
M. J. Glancey ◽  
C. R. Wolf
Keyword(s):  
Aflatoxin B1 ◽  
Human Liver ◽  
Multiple Forms ◽  
Cytochrome P 450

Aflatoxin B1 hydroxylation by the pregnenolone-16α-carbonitrile-inducible form of rat liver microsomal cytochrome P-450

1988 ◽  
Vol 9 (11) ◽  
pp. 2103-2108 ◽  
Author(s):  
Michael R. Halvorson ◽  
Steven H. Safe ◽  
Andrew Parkinson ◽  
Timothy D. Phillips
Keyword(s):  
Rat Liver ◽  
Aflatoxin B1 ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Preparation and characterization of monoclonal antibodies against a form of hamster liver cytochrome P-450 highly specific to aflatoxin B1

1988 ◽  
Vol 153 (1) ◽  
pp. 441-447 ◽  
Author(s):  
Momoko Sunouchi ◽  
Yukio Ishimi ◽  
Keinosuke Mizokami ◽  
Morio Fukuhara ◽  
Akira Takanaka ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Aflatoxin B1 ◽  
Liver Cytochrome ◽  
Cytochrome P 450

scholarly journals Changes in certain kinetic properties of hepatic microsomal aniline hydroxylase and ethylmorphine demethylase associated with postnatal development and maturation in male rats

1969 ◽  
Vol 113 (4) ◽  
pp. 681-685 ◽  
Author(s):  
Theodore E. Gram ◽  
Anthony M. Guarino ◽  
David H. Schroeder ◽  
James R. Gillette
Keyword(s):  
Enzyme Activity ◽  
Postnatal Development ◽  
Male Rats ◽  
Kinetic Properties ◽  
Michaelis Constant ◽  
Microsomal Cytochrome ◽  
Aniline Hydroxylase ◽  
Mixed Function Oxidases ◽  
Demethylase Activity ◽  
Cytochrome P 450

1. Changes in certain kinetic properties (Vmax. and apparent Km) of hepatic microsomal mixed-function oxidases have been studied as a function of postnatal development and maturation in male rats. 2. Microsomal cytochrome P-450 content changed only slightly between 1 and 12 weeks of age. 3. Aniline hydroxylase activity (Vmax.) increased abruptly between 1 and 2 weeks of age to greater than adult activities and then returned to a plateau value between 4½ and 12 weeks of age. Ethylmorphine demethylase activity remained low and relatively constant between 1 and 3 weeks of age and then increased markedly (∼100%) between 3 and 4½ weeks. 4. The apparent Michaelis constant (Km) for aniline hydroxylation increased almost linearly with time between 1 and 6 weeks of age and tended to reach a plateau value thereafter. The apparent Km for ethylmorphine demethylation increased between 1 and 3 weeks of age and then decreased abruptly to a constant value between 6 and 12 weeks. 5. The data indicate that developmental changes in the activity of these microsomal oxidases do not correlate temporally with each other or with changes in microsomal cytochrome P-450 content. 6. The most dramatic changes in enzyme activity were associated with early development (1–3 weeks) and weaning (3–4 weeks). 7. Changes in weight of seminal vesicle, a criterion of sexual maturation in male rats, were most prominent between 6 and 8 weeks of age and thus appeared to be separated in time from the prominent changes in enzyme activity.

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