scholarly journals Ouabagenin, an aglycone of cardiotonic steroid ouabain, functions as LXR ligand but avoids the increase in the SREBP-1 by inducing Krüppel-like factor 15

2021 ◽  
Vol 8 (1) ◽  
pp. 17-22
Author(s):  
Tomofumi Fujino ◽  
Kouta Sugizaki ◽  
Saki Ohkawa ◽  
Sana Fujikawa ◽  
Toshiyuki Oshima ◽  
...  
Keyword(s):  
Cardiotonic Steroid

Total Synthesis of the Cardiotonic Steroid (+)-Cannogenol

2021 ◽  
Vol 86 (4) ◽  
pp. 3605-3614
Author(s):  
Shogo Watanabe ◽  
Toshio Nishikawa ◽  
Atsuo Nakazaki
Keyword(s):  
Total Synthesis ◽  
Cardiotonic Steroid

Evaluation of Cardiotonic Steroid Modulation of Cellular Cholesterol and Phospholipid

2021 ◽  
Author(s):  
Lilian N. D. Silva ◽  
Israel J. P. Garcia ◽  
Jessica M. M. Valadares ◽  
Marco Tulio C. Pessoa ◽  
Marina Marques Toledo ◽  
...  
Keyword(s):  
Cellular Cholesterol ◽  
Cardiotonic Steroid ◽  
Steroid Modulation

A cardiotonic steroid bufalin-induced differentiation of THP-1 cells

1996 ◽  
Vol 52 (2) ◽  
pp. 321-329 ◽  
Author(s):  
Satoshi Numazawa ◽  
Naonori Inoue ◽  
Hironori Nakura ◽  
Ta-i Sugiyama ◽  
Emi Fujino ◽  
...  
Keyword(s):  
Induced Differentiation ◽  
Cardiotonic Steroid

scholarly journals Corrigendum: Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

2018 ◽  
Vol 9 ◽  
Author(s):  
Luiz H. A. Cavalcante-Silva ◽  
Éssia de Almeida Lima ◽  
Deyse C. M. Carvalho ◽  
José M. de Sales-Neto ◽  
Anne K. de Abreu Alves ◽  
...  
Keyword(s):  
Cardiotonic Steroid ◽  
Steroid Modulation

scholarly journals Ouabain enhances cell-cell adhesion mediated by β1-subunits of the Na+,K+-ATPase in CHO fibroblasts

2019 ◽  
Author(s):  
Claudia Andrea Vilchis-Nestor ◽  
María Luisa Roldán ◽  
Teresita Padilla-Benavides ◽  
Liora Shoshani
Keyword(s):  
Plasma Membrane ◽  
Cell Adhesion ◽  
Epithelial Cells ◽  
Signaling Pathways ◽  
Cell Adhesion Molecules ◽  
Basolateral Membrane ◽  
Adhesive Properties ◽  
Α Subunit ◽  
Cardiotonic Steroid ◽  
Pump Activity

AbstractAdhesion is an important characteristic of epithelial cells to provide a crucial barrier to pathogens and substances. In polarized epithelial cells, cell-adhesion depends on tight junctions, adherent junctions and the Na+,K+-ATPase. All these are located in the basolateral membrane of the cells. The hormone ouabain, a cardiotonic steroid, binds to the α subunit of the Na+,K+-ATPase, and inhibits the pump activity when used at above μM concentrations. At physiological nM concentrations, ouabain affects the adhesive properties of epithelial cells by inducing the expression of cell adhesion molecules through activation of signaling pathways associated to the α subunit. Our group showed that non-adherent CHO cells transfected with the canine β1subunit become adhesive, and that homotypic interactions between β1subunits of the Na+,K+-ATPase occur between neighboring epithelial cells. Therefore, in this study we investigated whether the adhesion between β1subunits was also affected by ouabain. We used CHO fibroblasts stably expressing the β1subunit of the Na+,K+-ATPase (CHO-β1) and studied the effect of ouabain on cell adhesion. Aggregation assays showed that ouabain increased the adhesion between CHO-β1cells. Immunofluorescence and biotinylation assays showed that ouabain (50 nM) increases the expression of the β1 subunit of the Na+,K+-ATPase at the cell membrane. We also screened the effect of ouabain on activation of signaling pathways in CHO-β1cells, and their effect on cell adhesion. We found that c-Src, is activated by ouabain and is therefore likely to regulate the adhesive properties of CHO-β1cells. Collectively, our findings suggest that the β1subunits adhesion is modulated by the levels of expression and activation of the Na+,K+-ATPase at the plasma membrane, which is regulated by ouabain.

scholarly journals Studies on Cardiotonic Steroid Analogs. V. : Synthesis of 17β(or α)-Isoxazolyl and Pyrazolyl-16-methyl-14β(or α)-androst-5-enes

1970 ◽  
Vol 90 (5) ◽  
pp. 537-543 ◽  
Author(s):  
SHUJIRO GOYA ◽  
KAZUTAKE SHIMADA ◽  
JUNICHI GOTO ◽  
SHINJI USUDA ◽  
TOSHIO NAMBARA
Keyword(s):  
Cardiotonic Steroid

Cardiotonic steroid in humans is not ouabain

1995 ◽  
Vol 73 (35) ◽  
pp. 8-9
Author(s):  
MAUREEN ROUHI
Keyword(s):  
Cardiotonic Steroid

1P-0095 Newly found cardiotonic steroid in saliva

2003 ◽  
Vol 4 (2) ◽  
pp. 40
Author(s):  
Y. Komiyama ◽  
N. Nishimura ◽  
X.H. Dong ◽  
M. Yoshika ◽  
H. Masaki ◽  
...  
Keyword(s):  
Cardiotonic Steroid
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