scholarly journals A 6-week repeated intranasal dose toxicity study of TTA-121, a novel oxytocin nasal spray, in rats

2019 ◽  
Vol 6 (7) ◽  
pp. 259-268 ◽  
Author(s):  
Junichi Namekawa ◽  
Emi Matsumoto ◽  
Hideshi Kaneko ◽  
Takasumi Shimomoto ◽  
Takayuki Okamura ◽  
...  
Keyword(s):  
Nasal Spray ◽  
Toxicity Study ◽  
Intranasal Dose

scholarly journals A 6-week repeated intranasal dose toxicity study of TTA-121, a novel oxytocin nasal spray, in cynomolgus monkeys

2019 ◽  
Vol 6 (7) ◽  
pp. 269-275 ◽  
Author(s):  
Emi Matsumoto ◽  
Junichi Namekawa ◽  
Hideshi Kaneko ◽  
Takasumi Shimomoto ◽  
Mitsuaki Masuyama ◽  
...  
Keyword(s):  
Nasal Spray ◽  
Toxicity Study ◽  
Cynomolgus Monkeys ◽  
Intranasal Dose

Vusion Ointment, Astelin Nasal Spray

2006 ◽  
Vol 40 (4) ◽  
pp. 46
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Nasal Spray

Toxicity Study of Di(2-Ethylhexyl)phthalate (DEHP) in Combination with Acetone in Rats

2000 ◽  
Vol 86 (2) ◽  
pp. 92-100 ◽  
Author(s):  
Majken DalgaardNote ◽  
Grete Ostergaard ◽  
Henrik Rye Lam ◽  
Ernst V. Hansen ◽  
Ole Ladefoged
Keyword(s):  
Toxicity Study ◽  
Ethylhexyl Phthalate

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Subchronic 90-day oral toxicity study of Chelidonii herba in pigs

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
P Kosina ◽  
J Drabek ◽  
J Vicar ◽  
J Vostalova ◽  
J Ulrichova ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity

PHARMACOGNOSTIC, ANTIOXIDANT AND ACUTE TOXICITY STUDY OF Ficus sycomorus (Linn) (Moraceae) ROOT AND STEM BARK

2020 ◽  
Vol 4 (2) ◽  
pp. 605-614
Author(s):  
Murtala M. Namadina ◽  
H. Haruna ◽  
U. Sanusi
Keyword(s):  
Acute Toxicity ◽  
Radical Scavenging ◽  
Stem Bark ◽  
The Body ◽  
Toxicity Study ◽  
Bark Extract ◽  
Root Extract ◽  
Acute Toxicity Study ◽  
Radical Scavenging Ability ◽  
Phytochemical Components

Most of biochemical reactions in the body generates Reactive Oxygen Species (ROS), which are involved in the pathogenesis of oxidative stress-related disorders like diabetes, nephrotoxicity, cancer, cardiovascular disorders, inflammation and neurological disorders when they attack biochemical molecules like proteins, lipids and nucleic acid. Antioxidants are used to protect the cells or tissues against potential attack by ROS. Most medicinal plants possess a rich source of antioxidants such as flavonoids, phenols, tannins, alkaloids among others. These phytochemicals are currently pursued as an alternative and complimentary drug. In this study, phytochemical components, antioxidant and acute toxicity study of the methanol extract of stem bark and root of F. sycomorus were carried out using standard methods. Findings from this study revealed the presence of some diagnostic microscopical features such as calcium oxalate, starch, gum/mucilage, lignin, Aleurone grain, suberized/Cuticular cell wall and inulin but calcium carbonate was absent in stem bark but present in the powdered root. Quantitative physical constants include moisture contents (6.40% and 7.82%), ash value (7.20% and 9.30 %) in stem bark and root respectively. Carbohydrates, alkaloid, flavonoids, saponins, tannins, glycoside, steroid, triterpenes and phenols were present in all the extracts. They were found to exhibit potent 1,1,-diphenyl 2-picryl hydrazyl (DPPH) free scavenging activity. The DPPH radical scavenging ability of the extracts showed the following trend Ascorbic acid < stem bark extract˃ root extract. The LD50 of the methanolic stem bark and root extracts were found to be greater than 5000 mg /kg and is considered safe for use. Nonetheless, further

103. Multi-Generation Reproductive Toxicity Study of Implanted Depleted Uranium in Rats

2004 ◽  
Author(s):  
D. Arfsten ◽  
A. Thitoff ◽  
E. Johnson ◽  
A. Jung ◽  
W. Jederberg ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Depleted Uranium ◽  
Toxicity Study
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