scholarly journals Impact of dietary calcium and phosphorus levels on an ovariectomized Sprague-Dawley rat model of osteoporosis

2019 ◽  
Vol 6 (7) ◽  
pp. 253-258 ◽  
Author(s):  
Atsushi Watanabe ◽  
Katsuhiro Miyajima ◽  
Noriko Kemuriyama ◽  
Hisashi Uchiyama ◽  
Takayuki Anzai ◽  
...  
Keyword(s):  
Rat Model ◽  
Dietary Calcium ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels

scholarly journals Effect of dietary calcium and phosphorus levels on growth, carcass characteristics and liver and kidney functions of growing Egyptian geese

2021 ◽  
pp. 101244
Author(s):  
Mahmoud Alagawany ◽  
Elwy Ali Ashour ◽  
Mohamed Soliman El-Kholy ◽  
Laila Ali Mohamed ◽  
Mohamed Ezzat Abd El-Hack
Keyword(s):  
Carcass Characteristics ◽  
Dietary Calcium ◽  
Liver And Kidney ◽  
Calcium And Phosphorus ◽  
Kidney Functions ◽  
Phosphorus Levels

scholarly journals Acute Histopathologic Findings Related to Needle Puncture Trauma during Subcutaneous Injection in the Sprague-Dawley Rat Model

2018 ◽  
Vol 47 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Yuval Ramot ◽  
Kamala Kannan ◽  
Sathish Reddy ◽  
H. Krishnappa ◽  
John E. Dillberger ◽  
...  
Keyword(s):  
Rat Model ◽  
Normal Saline ◽  
Subcutaneous Injection ◽  
Needle Puncture ◽  
Sprague Dawley ◽  
Injection Site Reactions ◽  
Sprague Dawley Rat ◽  
Specific Time Point ◽  
Histopathologic Findings ◽  
Time Point

It is important to detect injection site reactions during the nonclinical phases of drug development. However, differentiating between normal changes following needle trauma and changes due to the toxicity of injected drugs can be challenging. Therefore, we used the Sprague-Dawley rat model to evaluate the pathological findings expected following a single subcutaneous injection of normal saline. Rats were subcutaneously administered with normal saline, and the injection sites were examined microscopically. Inflammation was evident in most of the injection sites, mostly in minimal severity. Parakeratosis/epithelial crust was also seen in several sites, and necrosis was observed in a minority of the cases. These findings indicate that needle puncture trauma can present with some degree of inflammation and necrosis. Although limited to a specific time point and strain, this study shows that inflammation following subcutaneous injection can be attributed in part to the needle trauma and not necessarily to the drug itself.

Protective Effect of Madhuca longifolia Leaves in 7, 12-Dimethylbenz(a)anthracene Induced Mammary Carcinoma in Sprague Dawley Rat model

2019 ◽  
Vol 15 (66) ◽  
pp. 396
Author(s):  
Maheswari Chinnadhurai ◽  
Faisal Al-Otaibi ◽  
Kenneth Nelson ◽  
Geetha Kandasamy ◽  
Meena Shanmugam ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rat Model ◽  
Mammary Carcinoma ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Madhuca Longifolia

scholarly journals Effects of anti-obesity drugs, phentermine and mahuang, on the behavioral patterns in Sprague-Dawley rat model

2014 ◽  
Vol 30 (2) ◽  
pp. 73 ◽  
Author(s):  
Ryeo-Eun Go ◽  
Kyung-A Hwang ◽  
Seung-Hee Kim ◽  
Min-Young Lee ◽  
Cho-Won Kim ◽  
...  
Keyword(s):  
Rat Model ◽  
Behavioral Patterns ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Obesity Drugs

Complete sequence of a cholangiocarcinoma inbred Sprague-Dawley rat model mitochondrial genome

2014 ◽  
pp. 1-2
Author(s):  
Ai-Hua Luo ◽  
Gao-Feng Zhang ◽  
Yi-Fa Yin ◽  
Xin Li ◽  
Da-Li Feng ◽  
...  
Keyword(s):  
Mitochondrial Genome ◽  
Rat Model ◽  
Complete Sequence ◽  
Sprague Dawley ◽  
Sprague Dawley Rat
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