scholarly journals Gene expression profiles of immortalized S1, S2, and S3 cells derived from each segment of mouse kidney proximal tubules

2019 ◽  
Vol 6 (4) ◽  
pp. 117-123 ◽  
Author(s):  
Hitomi Fujishiro ◽  
Seiichiro Himeno
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Mouse Kidney ◽  
Proximal Tubules ◽  
Kidney Proximal Tubules

Transcriptional adaptation to Clcn5 knockout in proximal tubules of mouse kidney

2008 ◽  
Vol 33 (3) ◽  
pp. 341-354 ◽  
Author(s):  
Jerry Wright ◽  
Marcelo M. Morales ◽  
Jackson Sousa-Menzes ◽  
Debora Ornellas ◽  
Jennifer Sipes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Knockout Mouse ◽  
Gene Knockout ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Proximal Tubules ◽  
Dent Disease ◽  
Disease Genes ◽  
Knockout Mouse Model

Dent disease has multiple defects attributed to proximal tubule malfunction including low-molecular-weight proteinuria, aminoaciduria, phosphaturia, and glycosuria. To understand the changes in kidney function of the Clc5 chloride/proton exchanger gene knockout mouse model of Dent disease, we examined gene expression profiles from proximal S1 and S2 tubules of mouse kidneys. We found many changes in gene expression not known previously to be altered in this disease. Genes involved in lipid metabolism, organ development, and organismal physiological processes had the greatest number of significantly changed transcripts. In addition, genes of catalytic activity and transporter activity also had a great number of changed transcripts. Overall, 720 genes are expressed differentially in the proximal tubules of the Dent Clcn5 knockout mouse model compared with those of control wild-type mice. The fingerprint of these gene changes may help us to understand the phenotype of Dent disease.

1327: Gene Expression Profiles in Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 349-350
Author(s):  
Gaelle Fromont ◽  
Michel Vidaud ◽  
Alain Latil ◽  
Guy Vallancien ◽  
Pierre Validire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benign Prostatic Hyperplasia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostatic Hyperplasia
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