scholarly journals Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death

2015 ◽  
Vol 2 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Yuichi Miki ◽  
Jiro Akimoto ◽  
Aya Sato ◽  
Yasuyuki Fujiwara
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Laser Irradiance ◽  
T98g Cell ◽  
Talaporfin Sodium

scholarly journals Enhanced Malignant Phenotypes of Glioblastoma Cells Surviving NPe6-Mediated Photodynamic Therapy are Regulated via ERK1/2 Activation

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3641
Author(s):  
Tatsuya Kobayashi ◽  
Makoto Miyazaki ◽  
Nobuyoshi Sasaki ◽  
Shun Yamamuro ◽  
Eita Uchida ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Potential Therapeutic Target ◽  
Talaporfin Sodium ◽  
Polymerase Inhibitor ◽  
Human Gbm ◽  
Dose Dependent

To manage refractory and invasive glioblastomas (GBM)s, photodynamic therapy (PDT) using talaporfin sodium (NPe6) (NPe6-PDT) was recently approved in clinical practice. However, the molecular machineries regulating resistance against NPe6-PDT in GBMs and mechanisms underlying the changes in GBM phenotypes following NPe6-PDT remain unknown. Herein, we established an in vitro NPe6-mediated PDT model using human GBM cell lines. NPe6-PDT induced GBM cell death in a NPe6 dose-dependent manner. However, this NPe6-PDT-induced GBM cell death was not completely blocked by the pan-caspase inhibitor, suggesting NPe6-PDT induces both caspase-dependent and -independent cell death. Moreover, treatment with poly (ADP-ribose) polymerase inhibitor blocked NPe6-PDT-triggered caspase-independent GBM cell death. Next, it was also revealed resistance to re-NPe6-PDT of GBM cells and GBM stem cells survived following NPe6-PDT (NPe6-PDT-R cells), as well as migration and invasion of NPe6-PDT-R cells were enhanced. Immunoblotting of NPe6-PDT-R cells to assess the behavior of the proteins that are known to be stress-induced revealed that only ERK1/2 activation exhibited the same trend as migration. Importantly, treatment with the MEK1/2 inhibitor trametinib reversed resistance against re-NPe6-PDT and suppressed the enhanced migration and invasion of NPe6-PDT-R cells. Overall, enhanced ERK1/2 activation is suggested as a key regulator of elevated malignant phenotypes of GBM cells surviving NPe6-PDT and is therefore considered as a potential therapeutic target against GBM.

scholarly journals Effect of talaporfin sodium-mediated photodynamic therapy on cell death modalities in human glioblastoma T98G cells

2014 ◽  
Vol 39 (6) ◽  
pp. 821-827 ◽  
Author(s):  
Yuichi Miki ◽  
Jiro Akimoto ◽  
Michika Hiranuma ◽  
Yasuyuki Fujiwara
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Human Glioblastoma ◽  
Talaporfin Sodium

Photodynamic therapy with talaporfin sodium induces dose-dependent apoptotic cell death in human glioma cell lines

2013 ◽  
Vol 10 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Masateru Tsutsumi ◽  
Yuichi Miki ◽  
Jiro Akimoto ◽  
Jo Haraoka ◽  
Katsuo Aizawa ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cell Lines ◽  
Glioma Cell ◽  
Apoptotic Cell ◽  
Human Glioma ◽  
Talaporfin Sodium ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Dose Dependent

scholarly journals Photodynamic Therapy in Combination with Talaporfin Sodium Induces Mitochondrial Apoptotic Cell Death Accompanied with Necrosis in Glioma Cells

2013 ◽  
Vol 36 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Yuichi Miki ◽  
Jiro Akimoto ◽  
Sakino Yokoyama ◽  
Tomomi Homma ◽  
Masateru Tsutsumi ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Apoptotic Cell ◽  
Glioma Cells ◽  
Apoptotic Cell Death ◽  
Talaporfin Sodium

Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions

2017 ◽  
Author(s):  
Ellen Sletten ◽  
Rachael A. Day ◽  
Daniel A. Estabrook ◽  
Jessica K. Logan
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Induce Cell Death ◽  
Perfluorocarbon Nanoemulsions

<p>Photodynamic therapy (PDT) requires photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT. </p>

Evaluation of the efficacy and safety of salvage photodynamic therapy by talaporfin sodium for cervical esophageal cancers and lesions larger than 3 cm

Esophagus ◽  
2020 ◽  
Author(s):  
Tomoyuki Hayashi ◽  
Yoshiro Asahina ◽  
Hiroyoshi Nakanishi ◽  
Takeshi Terashima ◽  
Koichi Okamoto ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Efficacy And Safety ◽  
Talaporfin Sodium ◽  
Esophageal Cancers

Combination of photodynamic therapy with doxorubicin in osteosarcoma: Cell death and the role of oxidative stress

2016 ◽  
Vol 61 ◽  
pp. S141
Author(s):  
B. Serambeque ◽  
G. Brites ◽  
M. Laranjo ◽  
G. Chohfi de Miguel ◽  
A. Serra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Osteosarcoma Cell

Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage

2017 ◽  
Vol 13 (2) ◽  
pp. 204-220 ◽  
Author(s):  
Mans Broekgaarden ◽  
Ruud Weijer ◽  
AlbertC. van Wijk ◽  
RuudC. Cox ◽  
MaartenR. Egmond ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Tumor Cell ◽  
Zinc Phthalocyanine ◽  
Tumor Cell Death
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