scholarly journals BIOAVAILABILITY ENHANCEMENT AND LIPID NANOCARRIER BASED DELIVERY OF PEPTIDES AND PROTEINS

2020 ◽  
Vol 10 (1-3) ◽  
pp. 1-10
Author(s):  
Sunita Dahiya ◽  
◽  
Rajiv Dahiya ◽  
Keyword(s):  
Drug Delivery ◽  
Membrane Permeability ◽  
Protein Delivery ◽  
Enzymatic Degradation ◽  
Protein Drug ◽  
Biological Processes ◽  
Bioavailability Enhancement ◽  
Lipid Nanocarriers ◽  
Effective Delivery ◽  
Protein Drug Delivery

Peptides and proteins are vital biomacromolecules that perform several bodily functions in various physiological and biological processes. Being biocompatible and biodegradable, these macromolecules are considered promising platforms for delivery of drugs and genes. However, peptides and proteins suffer from major limitations including enzymatic degradation, short circulation half-lives, and poor membrane permeability that leads to poor bioavailability, challenging their effective delivery. This article briefly discusses the inherent challenges in peptide and protein delivery along with strategies for bioavailability enhancement and lipid nanocarriers as prospective systems for peptide and protein drug delivery.

New insights into an innovative Auricularia auricular polysaccharide pH-sensitive hydrogel for controlled protein drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59794-59799 ◽  
Author(s):  
Yibin Yu ◽  
Hao Pan ◽  
Yingying Wang ◽  
Wei Xiong ◽  
Qiantao Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Ph Sensitive ◽  
Protein Drug ◽  
Protein Drug Delivery ◽  
First Time ◽  
Polysaccharide Hydrogel ◽  
Ph Sensitive Hydrogel

An innovative pH-sensitive Auricularia auricular polysaccharide hydrogel was developed for effective controlled protein delivery for the first time.

A Novel Oral Protein-Drug Delivery System with Bilayer Shell-Core Structure

2020 ◽  
Author(s):  
Xuan Zhang ◽  
Yanjun Tong ◽  
Xiaomei Lyu ◽  
Jianfen Ye ◽  
Ruijin Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Structure ◽  
Protein Drug ◽  
Protein Drug Delivery

A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery

2004 ◽  
Vol 96 (2) ◽  
pp. 285-300 ◽  
Author(s):  
Sung-Ching Chen ◽  
Yung-Chih Wu ◽  
Fwu-Long Mi ◽  
Yu-Hsin Lin ◽  
Lin-Chien Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Ph Sensitive ◽  
Protein Drug ◽  
Protein Drug Delivery ◽  
Ph Sensitive Hydrogel

Nanostructures for protein drug delivery

2016 ◽  
Vol 4 (2) ◽  
pp. 205-218 ◽  
Author(s):  
Juliana de Almeida Pachioni-Vasconcelos ◽  
André Moreni Lopes ◽  
Alexsandra Conceição Apolinário ◽  
Johanna Karina Valenzuela-Oses ◽  
Juliana Souza Ribeiro Costa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Protein ◽  
Protein Drug ◽  
Nanostructured Systems ◽  
Protein Drug Delivery

Nanostructured systems, such as nanoemulsions and polymersomes, are important tools to develop safe and effective therapeutic protein preparations.

Multifunctional nanoparticles for oral protein drug delivery

2016 ◽  
Vol 120 ◽  
pp. S19
Author(s):  
Er-Yuan Chuang ◽  
Kun-Ju Lin ◽  
Fang-Yi Su ◽  
Fwu-Long Mi ◽  
Chiung-Tong Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protein Drug ◽  
Multifunctional Nanoparticles ◽  
Protein Drug Delivery

Synthesis and characterization of heparin conjugated Tetronic®–PCL copolymer for protein drug delivery

2007 ◽  
Vol 7 ◽  
pp. e49-e52 ◽  
Author(s):  
Jung Seok Lee ◽  
Dong Hyun Go ◽  
Jin Woo Bae ◽  
In Kwon Jung ◽  
Joon Woo Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Synthesis And Characterization ◽  
Protein Drug ◽  
Protein Drug Delivery
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