scholarly journals Histopathological Study of Epithelial, Melanocytic And Adnexal Tumors Of Skin- A Retrospective Study In A Tertiary Care Centre

2021 ◽  
Vol 8 (8) ◽  
pp. A189-195
Author(s):  
Sandhya Pitla ◽  
Vijayasri Dara
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Verrucous Carcinoma ◽  
Tertiary Care ◽  
Chemical Exposure ◽  
Benign Tumors ◽  
Histopathological Study ◽  
Skin Appendages

Background and objectives:  To classify and identify various skin tumors and study their variations according to age and sex. The most common predisposing factors being   fair skin, sun exposure, chemical exposure, HPV infection in the setting of immunosuppression. Methods: This was an observational study carried out in the Department of Pathology at private Medical College of coastal Andhra from July 2018 to June 2020. Result: The present study included histopathological study of 71 cases of tumors of skin and its adnexae over a period of two years.  Out of the 71 tumors, 43 were diagnosed as benign and 28 as malignant tumors of skin constituting 61% and 39% respectively. The ratio of benign to malignant tumors was 1:0.63. Among the 43 benign tumors 20 (46.5%) were tumors of skin appendages, 15 (34.9%) were tumors of epidermis, 8 (18.6%) were of melanocytic origin.  Among the 28 malignant tumors 25 (89.3%) were tumors of epidermis, 2 (7.1%) were melanocytic tumors and 1 (3.6%) was tumor of skin appendages. Among the malignant epidermal tumors squamous cell carcinoma was the most common constituting 42.9% (12 cases). Conclusion: The present study concludes that benign tumors are most common when compared to malignant tumors of skin. Among the malignant tumors, Squamous cell carcinoma falls as the most common variety of skin followed by Basal cell carcinoma and verrucous carcinoma. Among the benign tumors, tumors of epidermal origin are most frequent followed by tumors of sweat gland and adnexal-hair follicle origin.

scholarly journals A Rapid Growth of Verrucous Carcinoma After Biopsy: Treatment and Reconstruction

2021 ◽  
Vol 8 (1) ◽  
pp. 10-14
Author(s):  
Angelica Gracia Budhipramono ◽  
Sweety Pribadi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Verrucous Carcinoma ◽  
Experimental Studies ◽  
Nasal Reconstruction ◽  
Forehead Flap ◽  
Verrucous Squamous Cell Carcinoma ◽  
One Year

Summary: An increasing amount of evidence from clinical and experimental studies suggests that biopsies, thought to assist with definitive diagnoses, may aggravate tumor progression. We present a case of fast-growing giant verrucous squamous cell carcinoma, observed two weeks following biopsy. A 38-year-old man presented with a nose tumor that recurred two weeks after a biopsy and debridement to remove a lesion that was thought to be an abscess. Wide excision was performed on the tumor, frozen sectioned; the defect was reconstructed with a two-step forehead flap. The rapid tumor growth observed in this case raises the question of whether biopsies or other interventions may accelerate the growth of malignant tumors. Verrucous squamous cell carcinoma is slow-growing with a predilection for oral and nasal mucosa and rarely metastasizes. The patient presented here is an unusual case, with a tumor rapidly growing within fifteen days. A two-staged paramedian forehead flap is the workhorse of nasal reconstruction. Even though the benefit of doing biopsies overall outweighs the potential side effects, further research is required to determine whether biopsies affect the progression of the tumor. Early differential diagnosis is also crucial, as it may affect the patient's plan of treatment and prognosis. Giant tumors on the facial area may cause a functional and cosmetic disturbance. A two-step forehead flap produces a satisfactory cosmetic appearance for the patient one-year post-procedure.

A survey of tumors affecting cattle, buffaloes and sheep, in El-Dakahlyia Governorate

2019 ◽  
Vol 20 (2) ◽  
pp. 70-78
Author(s):  
Inas Moharram ◽  
Walaa Awadin ◽  
Mohamed Hamed ◽  
M Salem ◽  
E Mosbah
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Cavity ◽  
Malignant Tumors ◽  
Benign Tumors ◽  
Mesenchymal Tumors ◽  
Epithelial Tumors ◽  
Well Differentiated ◽  
Vaginal Leiomyoma

In a 2-year survey of tumors occurring in ruminants reared in El-Dakahlyia Governorate, Egypt during the period from October 2016 to October 2018. 66 tumor masses were collected: 60 from cattle, 2 from buffaloes and 4 from sheep. According to histopathology of cattle tumors, 15 neoplasms were diagnosed as cutaneous papilloma, 5 neoplasms were diagnosed as cutaneous fibropapillomas, 25 neoplasms were diagnosed as squamous-cell carcinoma (SCC) of the eye; 8 neoplasms were diagnosed as SCC of perineum, 1 neoplasm was diagnosed as SCC in skin of muzzle, 2 neoplasms were diagnosed as epulis in dental pad, 2 neoplasms were diagnosed as vaginal leiomyoma, 1 neoplasm was diagnosed as fibroma and 1 neoplasm was diagnosed as liposarcoma. Histopathology of buffalo tumors revealed SCC in head skin (1 case) and buccal cavity (1 case). Histopathology of sheep tumors revealed SCC in skin under the tail (2 cases), skin of groin (1 case) and skin of abdomen (1 case). In conclusion, cattle (60/66) were more susceptible to tumors than buffaloes (2/66) and sheep (4/66). Females accounted for a higher percentage of the neoplasms (47/66) than males (19/66). Adult animals aged above 2 years were more frequently affected than young. The occurrence of epithelial tumors (60/66) was greater than the mesenchymal tumors (6/66). The most common epithelial tumors were ocular SCC and cutaneous papilloma. Number of malignant tumors (41/66) was higher than number of benign tumors (25/66). Variable degrees of bovine SCC differentiation were detected. Meanwhile ovine SCC appeared only well differentiated.

HISTOPATHOLOGICAL STUDY OF COLPOSCOPIC BIOPSY OF CERVICES IN A TERTIARY CARE HOSPITAL (RAJSHAHI MEDICAL COLLEGE) IN BANGLADESH

2021 ◽  
pp. 166-168
Author(s):  
Monira Parveen ◽  
SM Asafudullah ◽  
M. Rokeya Khatun ◽  
Md. Nowshad Ali ◽  
Khadiza Khanom ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Invasive Squamous Cell Carcinoma ◽  
Care Hospital ◽  
Medical College ◽  
Chronic Cervicitis

Introduction: Colposcopy is done to detect cervical cancer and changes that may lead to cervical cancer. We aimed our study to observe the incidence of different pathologies of the cervix in Colposcopic specimens in Rajshahi Medical College of Bangladesh. Materials and Methods: Retrospective data were collected from the routine histopathological laboratory in the department of pathology Rajshahi Medical College and were recorded during a study period of 1 year (July 2019 to June 2020). Observations: Colposcopic biopsy is one of the commonest diagnostic procedures for assessing cervical Pathosis. Out of 641 specimens more than half, 365 specimens (56.50%) were Chronic Cervicitis. In present study, Chronic Cervicitis with squamous metaplasia and Invasive squamous cell carcinoma became the 2nd, 16.39% (105 specimens), and 3rd, 13.42% (86 specimens) most pathology involving the cervix. Cervical polyp, Endocervical and Leiomyomatous constitute 6.39% and 1.57% of the specimens respectively. 4.36% (28 specimens) of the study sample were the Intraepithelial neoplasia (CIN I, CIN II, CIN III). Adenocarcinoma and Clear cell carcinoma constitute 0.79% and 0.16% of the study specimens. 50 % of the cervical squamous cell carcinoma was moderately differentiated and well-differentiated and poorly differentiated squamous cell carcinoma constitutes 30.23% and 19.77% respectively. Conclusions: Colposcopic examination of cervical biopsy specimens helps to detect the exact causes and underlined pathology

Oral Cancer: Raising Awareness of the Importance of Suspicion in Early Detection

2021 ◽  
Vol 10 (1) ◽  
pp. 10-12
Author(s):  
Farooq Ahmed ◽  
Honieh Bolooki ◽  
Senathrajah Ariyaratnam ◽  
Michael N. Pemberton
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Mucosal Lesion ◽  
Morbidity And Mortality ◽  
Raising Awareness ◽  
Suspicious Lesions

Oral cancer is a significant cause of morbidity and mortality worldwide. In this article we present two cases of potentially innocuous looking lesions, initially thought to be traumatic in origin, but later diagnosed as cancer. The first patient presented with a persistent laceration thought to be caused by an accidental shaving injury, which was subsequently diagnosed as squamous cell carcinoma. The second patient presented with a hyperplastic mucosal lesion, suspected as forming due to denture-clasp irritation, which was subsequently diagnosed as proliferative verrucous carcinoma. The importance of early detection and palpation of suspicious lesions is emphasised in this article.

scholarly journals THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the progression of esophageal squamous cell carcinoma

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Jiwei Cheng ◽  
Haibo Ma ◽  
Ming Yan ◽  
Wenqun Xing
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Malignant Tumors ◽  
Migration And Invasion ◽  
Positive Feedback Loop

AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in the digestive system with a high incidence and poor prognosis. Long non-coding RNAs (LncRNA) have been reported to be closely associated with the occurrence and development of various human cancers. Data from GSE89102 shows an increase of THAP9-AS1 expression in ESCC. However, its functions and mechanisms underlying ESCC progression remain to be investigated. In this study, we found that THAP9-AS1 was overexpressed in ESCC tissues and cells. High THAP9-AS1 expression was positively correlated with tumor size, TNM stage, lymph node metastasis, and worse prognosis. Functionally, depletion of THAP9-AS1 suppressed cell proliferation, migration, and invasion, while enhanced apoptosis in vitro. Consistently, knockdown of THAP9-AS1 inhibited xenograft tumor growth in vivo. Mechanistically, THAP9-AS1 could serve as a competing endogenous RNA (ceRNA) for miR-133b, resulting in the upregulation of SOX4. Reciprocally, SOX4 bound to the promoter region of THAP9-AS1 to activate its transcription. Moreover, the anti-tumor property induced by THAP9-AS1 knockdown was significantly impaired due to miR-133b downregulation or SOX4 overexpression. Taken together, our study reveals a positive feedback loop of THAP9-AS1/miR-133b/SOX4 to facilitate ESCC progression, providing a potential molecular target to fight against ESCC.

Radionecrosis after Treating Oral Cavity & Oropharyngeal SCC

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P43-P44
Author(s):  
Sundip H Patel ◽  
Mike Yao ◽  
Tara Brennan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Care Facility ◽  
Tertiary Care Facility ◽  
Pertinent Data ◽  
Associated Risk Factors ◽  
Oropharynx Squamous Cell Carcinoma

Objective 1) The primary goal of this study was to evaluate the incidence of radionecrosis among patients treated with radiation therapy for oral cavity & oropharynx squamous cell carcinoma at our institution. Many patients with oral cavity & oropharyngeal cancers receive radiation to preserve the tongue, knowing the risks of post-treatment radionecrosis. However, recent protocols have intensified chemo-radiotherapy in an effort to improve local control while possibly increasing risk. 2) Among those patients with radionecrosis, we also analyzed their cancer treatment regimen, associated risk factors, the severity of the radionecrosis and the resulting treatment they recieved. Methods We performed a retrospective review of all adult patients at our tertiary care facility with biopsy proven squamous cell carcinoma of the oral cavity & oropharynx from 1999 to 2007 who completed a full course of radiotherapy at our facility with at least 6 months follow-up. Medical charts were reviewed for the presence of radionecrosis as well as for other corresponding, pertinent data. Results After reviewing 241 patients, a total of 107 patients were included. 5 of 65 with oropharynx disease had radionecrosis, revealing an incidence of 7.7%. Among the oral cavity group there were 8 out of 42 patients with radionecrosis, revealing an incidence of 19%. The overall incidence among our treatment group was 12.1%. Conclusions Radiation-induced necrosis of the oral cavity & oropharynx is still a significant complication in the treatment of head and neck cancer and poses a higher risk in the oral cavity than the oropharynx.

Histopathological spectrum of oral cavity lesions – A tertiary care experience

2021 ◽  
Vol 8 (3) ◽  
pp. 364-368
Author(s):  
Ishani Gupta ◽  
Rekha Rani ◽  
Jyotsna Suri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Proper Management ◽  
The World ◽  
One Year

Oral cancer is one of a major health problem in some parts of the world especially in the developing countries. Oral cancer is the sixth most common cancer in the world whereas in India it is one of the most prevalent cancer. Oral cavity lesions are usually asymptomatic. Accurate diagnosis of the lesion is the first step for the proper management of patients and histopathology is considered as the gold standard. The objective is to study the different patterns of oral cavity lesions seen in a tertiary care hospital of Jammu: One year retrospective study. Post graduate department of pathology.: It was a retrospective study carried out in a tertiary care centre for a period of one year from March 2020 to Feb 2021. 148 cases of oral cavity lesions were included in this study. The parameters that were included in the study were sociodemographic data, site of the lesion, clinical features and histological diagnosis. Data collected was analysed.148 cases of oral lesions were identified during the period of study. The age of patients varied from 5 to 78years and Male to Female ratio was 2.2:1. Buccal mucosa (30%) was the most common site involved which was followed by tonsil (19%). Out of 148 cases 70 cases were malignant, 10 cases pre malignant and 21 cases were benign. Squamous cell carcinoma (33.7%) was the most common lesion present in our study. Oral cavity lesions have a vast spectrum of diseases which range from tumour like lesions to benign and malignant tumours. Our study concluded that squamous cell carcinoma was the most common malignant lesion of oral cavity. Histological typing of the lesion is important for confirmation of malignancy and it is essential for the proper management of the patient.

VERRUCOUS CARCINOMA AS A CLINICOPATHOLOGIC VARIANT OF SQUAMOUS CELL CARCINOMA

2017 ◽  
Vol 124 (2) ◽  
pp. e80
Author(s):  
ALOIZIO PREMOLI MACIEL ◽  
VICTOR TIEGHI-NETO ◽  
CARLA RENATA SANOMIYA IKUTA ◽  
LUIZ ANTONIO DE ASSIS TAVEIRA ◽  
JOSÉ BURGOS PONCE ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma

scholarly journals Squamous cell carcinoma mimicking a wart

2021 ◽  
Vol 12 (4) ◽  
pp. 471-472
Author(s):  
Aida Oulehri ◽  
Sara Elloudi ◽  
Hanane Baybay
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Soft Tissues ◽  
Verrucous Carcinoma ◽  
Previous History ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Complete Surgical Excision ◽  
Safety Margins

Sir, Cutaneous squamous cell carcinoma, a malignant proliferation of the cutaneous epithelium, represents the second most common non-melanoma skin cancer after basal cell carcinoma [1]. Verrucous carcinoma (VC) is a rare, low-grade, well-differentiated squamous cell carcinoma most commonly seen in the mucosa, infrequently reported to occur in the skin, where it is a slow-growing and locally aggressive tumor. It is not uncommon for cutaneous verrucous carcinomas to be mistaken for the more frequent wart (verruca vulgaris) and treated accordingly [2]. The etiopathogenesis of VC is not completely known. One theory mentions the human papillomavirus (HPV) infection; with plantar lesions, the types involved are reported to be 16 and 11 [3]. Histopathological diagnosis is difficult and needs one or more broad and in-depth biopsies. Morbidity results from the local destruction of the skin and soft tissues and, occasionally, from a perineural, muscular, and even bony invasion. Metastasis to regional lymphatic ganglia is rare, found in 5% of cases [4]. VC bears a high risk of local relapse. No matter the treatment employed, the rate of recurrence varies from 30% to 50% and usually is not the result of incomplete surgical interventions. The treatment of choice is complete surgical excision with safety margins [5]. A forty-year-old female patient with no previous history presented herself with a hyperkeratotic lesion on the right foot persistent for two years, which she had been manipulating routinely, which had progressively been increasing in size for the previous year, and which, for the previous three months, had become painful and bleeding. An examination revealed a hyperkeratotic plaque with a hyperpigmented border, hard on palpation, adherent to the deep plane, and with an eroded surface (Fig. 1). Dermoscopy was able to find a papillomatous appearance surrounded by dotted vessels (Fig. 2). This dermoscopic aspect typical of vulgar warts was confusing. Indeed, dermoscopy of the foot wart shows red or black dots in the center of papillomatous structures, which are thrombosed vessels supplying the wart; hence the importance, in our opinion, of the clinical and pathological correlation. For this reason, we performed a skin biopsy; an anatomopathological study found a squamous cell carcinoma of the verrucous type.

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