scholarly journals Applicability of Cytological Grading of Carcinoma Breast

2021 ◽  
Vol 8 (7) ◽  
pp. A174-178
Author(s):  
Saroj Pachori ◽  
Kriti Chaturvedi ◽  
Geeta Pachori ◽  
Tarun Tiwari ◽  
Disha Jain
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Incidence ◽  
Needle Aspiration ◽  
P Value ◽  
Grading System ◽  
Management Options ◽  
Grade Ii ◽  
A Prospective Study ◽  
Grade Iii ◽  
Breast Malignancies

Background: In India breast cancer incidence is on rise and large number of cases occur before 50 years of age. Early diagnosis and proper treatment are known to increase the survival of the patients. As fine needle aspiration cytology is widely used as a preliminary mode for the diagnosis of breast malignancies, adding a reliable grading system in reporting shall aid in planning the management options. Methods: It’s a prospective study done on 100 cases of breast malignancies from June 2018 to May 2020 in department of Pathology JLNMC, Ajmer. Cytology smears were stained with H&E and Geimsa and graded according to Robinson’s cytological grading system while their corresponding histopathological sections were stained with H&E and graded as per Elston and Ellis modification of Scarff Bloom & Richardson grading system and the results were compared. Result: Out of 100 cases of breast cancer evaluated in cytology 29% were grade I, 56% were grade II and 15% were grade III. On histopathological evaluation 25% were grade I, 54% were grade II while 21% were grade III. A highly significant association between the two grading systems was observed with coefficient of correlation 0.831, p value of <0.001 and concordance rate 80%. Conclusion: There is high degree of concordance between the Robinson’s and Elston and Ellis modification of Scarff Bloom & Richardson grading system. Robinson’s method is an easy and quick and reliable method to grade carcinomas of breast, hence it should be included in cytology reporting of breast carcinomas.

scholarly journals Prognostic role of robinson cytological grading system in breast cancer in correlation with the histological grading of modified bloom richardson in Iraq

2018 ◽  
Vol 6 (4) ◽  
pp. 1139
Author(s):  
Noora M. Kareem ◽  
Nihad Salih Rahmatullah
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Concordance Rate ◽  
Grading System ◽  
Histological Grading ◽  
Fine Needle ◽  
Grade Ii ◽  
Grade Iii

Background: The breast cancer is increasing in developing countries and the management options are widened, therefore providing the surgeon with accurate prognostic information on which the mode of therapy will be chosen became so important. Robinson grading system was found to be useful in grading breast carcinoma in fine needle aspirates. The objectives of the study were to estimate the benefits of using Robinson grading system in fine needle aspiration for breast cancer and to estimate the correlation of Robinson grading system in fine needle aspiration with histological grading.Methods: There were Seventy cases of invasive ductal carcinoma was graded on FNA aspirates by Robinson grading system using six cytological parameters (cell dissociation, cell size, cell uniformity, nucleolus, nuclear margin, and nuclear chromatin).Results: The concordance rate between grade I tumors on cytology and histology was 100%, while for grade II tumors it was 62.5% and for grade III tumors it was 100%. The absolute concordance rate was 87.5%, the Spearman rank correlation coefficient (r) was 0.762, p value was (0.00), the sensitivity of Robinson’s cytological grading system in cytological grade I tumors was 73.33% and specificity was 100%. In cytological grade II tumors the sensitivity was 100% and specificity was 76% and in cytological grade III tumors the sensitivity is 100% and specificity was 100%.Conclusions: Robinson’s cytological grading of breast carcinoma correlates well with Bloom-Richardson’s histological grading system and could be a helpful parameter in selecting a neoadjuvant treatment for the breast cancer patients on fine needle aspiration cytology alone.

scholarly journals Characteristics and Histopathological Grading of Malignant Spiculated Mass in regards to Histopathological Grading of Breast Cancer Based on The Nottingham Grading System

2020 ◽  
Vol 3 (1) ◽  
pp. 33
Author(s):  
Andi Syarti ◽  
Ulinta Pasaribu ◽  
Dyah Fauziah ◽  
Lies Mardiyana ◽  
Tri Wulanhandarini
Keyword(s):  
Breast Cancer ◽  
Mitotic Index ◽  
Proliferation Index ◽  
Grading System ◽  
Nuclear Pleomorphism ◽  
Histopathological Grade ◽  
Grade Ii ◽  
Tubular Formation ◽  
Histopathological Grading ◽  
Grade Iii

Introduction: Spiculation in mammography is a typical finding for invading breast cancer and is an important criterion in diagnosis and in predicting prognostic and plays an important role in management. The purpose of this research is to determine the characteristics of malignant spiculating mass in mammography in regards to histopathological grading using The Nottingham Grading System.Methods: Patients whom had spiculation in mammography was reviewed using medical record data by two breast imaging consultants and then combined with The Nottingham Grading System criteria obtained from histopathological examination results of core biopsy and surgery specimen. There was 29 cases that met the inclusion criteria.Results: Of the 29 patients that met the inclusion, the spiculated masses grade I, II has mitotic index of 0-12, grade III has mitotic index of 13-25. Histopathologic grade II, III has the most tubular formation of <10%, grade I has 10-75%. Grade I, II has moderate nuclear pleomorphism, grade III has severe nuclear pleomorphism. Most were grade III (44.8%), followed by grade II (37.9%), and minimally grade I (17.2%). Most patients are in stage 3 breast cancer.Conclusion: Malignant spiculated mass with grade I, II has low proliferation index (mitotic index 0-12), histopathological grade II, III had worse cellular differentiation (tubular formation <10%), histopathological grade II, III has moderate to severe nuclear pleomorphism.

scholarly journals A Study of Microvascular Density in Carcinoma of Breast with CD34 Immunostaining

2021 ◽  
pp. 1-12
Author(s):  
Bijoya Debnath ◽  
Mary Lilly
Keyword(s):  
Breast Cancer ◽  
Blood Vessels ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
P Value ◽  
Vascular Density ◽  
Breast Cancer Patients ◽  
Sprouting Angiogenesis ◽  
Grade Ii ◽  
Grade Iii

Introduction: Tumor agiogenesis is generally classified in to two types, namely, sprouting and intussusceptive angiogenesis. The formation of new blood vessels from the already existing is termed as sprouting angiogenesis.  Many growth factors including endothelial growth factor (VEGF) contribute the formation of new vessels at the tumor sites. On other hand, the tumor able to split the existing blood vessels, this type is termed as intussuscepted angiogenesis and discovered in human colon adenocarcinoma xenograft.  In intussuscepted angiogenesis, an existing blood vessel splits into two new blood vessels by formation of trans vascular pillars. Objective: The present study aimed to analyse the nicrovascular density on breast cancer patients using CD 34 immunostaining method. Results: This mis-regulation may lead to the development of cancers. Histological grading with Grade II were more with 19 (63.3%) cases followed by Grade I with 4 (13.3%) and Grade III with 3 (10%) cases. There was increase in mean vascular density in Grade II when compared with Grade I and Grade III. However no significant correlation was observed statistically with a P value of 0.176. Using different antibodies such as CD34, CD31, Factor VIII and CD105 to microvessels differentiation was highlighted. Conclusion: The results showed that the anti-CD34 monoclonal antibody is more sensitive than the anti- CD31 antibody in calculation of MVD in breast cancer as mentioned in previous studies.

scholarly journals Correlation of Robinson’s Cytological Grading of Breast Carcinoma with Bloom Richardson’s Histological Grading – A Teaching Institutional Experience in Mandya, Karnataka

2021 ◽  
Vol 8 (21) ◽  
pp. 1620-1623
Author(s):  
Kusuma Kodihalli Nagaraju ◽  
Chandana Nagendra ◽  
Shilpa Madhav Shetty
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Histological Grading ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Grade Ii ◽  
Needle Aspiration Cytology ◽  
Grade Iii

BACKGROUND Breast cancer is increasing in developing countries and the management options are wide; therefore, providing the surgeon with accurate prognostic information on which mode of therapy will be chosen becomes important. Fine needle aspiration cytology (FNAC) is a routinely used initial investigation of choice for rapid diagnosis of breast cancer. Apart from diagnosis of cancer, it also has the ability to predict the grade on smears which will add its diagnostic value without any additional morbidity or expense for the patients. Among various cytological grading systems, Robinson grading is most commonly used for breast carcinoma in fine needle aspirates. The purpose of this study is to evaluate the correlation between Robinson’s cytological grading and Bloom Richardson’s histological grading. METHODS This is a 3 - year retrospective analytical study. 40 cases of infiltrating duct carcinoma (IDC) of breast diagnosed on cytology were included in the study. Cytological grading was done using Robinson’s grading and corresponding histopathology slides were taken, and histological grading using Bloom Richardson’s system was done. Finally, correlation between cytological and histological grading was done using statistical package for social sciences (SPSS) software. RESULTS Age of the patients varied between 32 and 70 yrs. Cytologically, 32.5 % cases were grade I, 40 % were grade II and 27.5 % cases were grade III respectively. Histologically 22.5 %, 47.5 % and 30 % cases were grade I, grade II, and grade III, respectively. Concordance rate between grade I tumours in cytology and histology was 53.84 %, for grade II tumours it was 75 %, and for grade III tumours it was 63.63 %. The absolute concordance rate was 65 %. CONCLUSIONS Robinson’s cytological grading (RCG) of breast carcinoma correlates well with Bloom - Richardson’s histological grading system and could be a helpful parameter in selecting a neoadjuvant treatment for the breast cancer patients on fine needle aspiration cytology alone. KEYWORDS Breast Carcinoma, Robinson’s Cytological Grading, Bloom Richardson’s Histological Grading

scholarly journals Cytological grading of breast carcinoma on fine needle aspirates and its relation with histological grading

2015 ◽  
Vol 04 (01) ◽  
pp. 032-034 ◽  
Author(s):  
Jyoti Prakash Phukan ◽  
Anuradha Sinha ◽  
Jatindra Prasad Deka
Keyword(s):  
Breast Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Needle Aspiration ◽  
Grading System ◽  
Low Grade ◽  
Histological Grading ◽  
Fine Needle ◽  
Primary Treatment Modality ◽  
Grade Ii ◽  
Grade Iii

Abstract Background: Grading of breast carcinoma on fine needle aspiration cytology (FNAC) is beneficial for selecting patients for neoadjuvant chemotherapy. Aims: To grade the breast carcinoma on FNAC using Robinson grading system and to assess the concordance of cytological grading (CG) with histological grading (HG) using Elston-Ellis modification of Scarff-Bloom-Richardson grading system. Materials and Methods: The study was conducted for 1-year, comprising of 50 female patients attending outpatient departments (OPD) as well as admitted in various surgical wards of a teaching hospital, diagnosed as breast carcinoma. FNAC smears were stained with May-Grunwald-Giemsa and Papanicolaou (Pap) stains and CG was done using Robinson system on Pap stained smears. The results were compared with HG system after resection of tumors. Results: Of 50 cases, 14 (28%) cases were graded as grade I, 24 (48%) grade II, and 12 (24%) grade III by CG, whereas 9 (18%), 28 (56%) and 13 (26%) cases were graded as grade I, II and III by HG. The result showed overall 72% concordance of CG with HG, with grade II and grade III showing highest degree of concordance (83.33%), which is comparable to previous studies. Kappa measurement showed a higher degree of agreement in high-grade tumors compared with low-grade tumors (0.73 in grade III, 0.53 in grade II and 0.39 in grade I). Conclusion: Cytological grading is comparable to HG in majority of cases. Because neoadjuvant chemotherapy is becoming increasingly popular as primary treatment modality of breast cancer, CG could be a useful parameter in selecting the mode of therapy and predicting tumor behavior.

HUBUNGAN ANTARA UMUR DAN STATUS PERKAWINAN DENGAN KEJADIAN KANKER PAYUDARA DI INSTALASI BEDAH RUMAH SAKIT UMUM PUSAT DR. MOHAMMAD HOESIN PALEMBANG TAHUN 2012

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Rini Mayasari Rini Mayasari
Keyword(s):  
Breast Cancer ◽  
Marital Status ◽  
Cancer Incidence ◽  
Random Sampling ◽  
Breast Cancer Incidence ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Systematic Random Sampling ◽  
Breast Cancer Event

ABSTRACT Breast cancer on the mark with the growth or uncontrolled growth of cells that are excessive. Factors affecting the incidence of breast cancer include maternal age, marital status, family history, hormone use, radiation, manarche, and obesity. The purpose of this study was to determine the relationship between Age and Marital Status of Mother with Breast Cancer incidence in the Installation Surgeon General Hospital Dr. Mohammad Hoesin Palembang in 2012. The study design was analytical descriptive with the approach in which the independent variables Cross Sectional Age Mother and Status Perkawianan and dependent variables in breast cancer incidence collected at the same time. The study population was all women who develop breast cancer in the Installation General Hospital Surgery Center Dr. Mohammad Hoesin Palembang in 2012 and samples taken by systematic random sampling with a sample of 130 respondents. The results of univariate analysis of data showed that respondents had breast cancer with a percentage of total 58 (44.61%) while respondents who had not had breast cancer totaled 72 by the percentage (63.39%). Respondents by Age Mothers who are at risk amounted to 34 by the percentage (26.15%) while respondents with Age Mothers who are not at risk amounted to 96 by the percentage (73.85%). Respondents by Marital Status is married and the mother who totaled 69 by the percentage (53.07%) and Marital Status with the status of unmarried women totaled 61 by the percentage (46.03%). Of Chi-Square test results found no significant relationship between Age Mothers with Breast Cancer event in which the p value = 0.007, no significant relationship between Marital Status in Breast Cancer event in which the p value = 0.030. Based on the results of the study, researchers suggest counseling efforts, medical knowledge and improve the quality of health services in order to reduce the incidence of breast cancer..   ABSTRAK Kanker payudara di tandai dengan pertumbuhan atau perkembangan tidak terkontrol dari sel-sel yang berlebihan. Faktor-faktor yang mempengaruhi kejadian kanker payudara antara lain umur ibu, status perkawinan, riwayat keluarga, penggunaan hormon, radiasi, manarche, dan obesitas. Tujuan penelitian ini adalah untuk mengetahui hubungan antara Umur Ibu dan Status Perkawinan dengan kejadian Kanker Payudara di Instalasi Bedah Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2012. Desain Penelitian ini adalah deskriptif analitik dengan pendekatan Cross Sectional dimana variabel independen Umur Ibu dan Status Perkawianan dan variabel dependen kejadian kanker payudara dikumpulkan dalam waktu yang bersamaan. Populasi penelitian ini adalah semua ibu yang menderita kanker payudara di Instalasi Bedah Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2012 dan sampel di ambil secara systematic random sampling dengan jumlah sampel 130 responden. Hasil analisis univariat data menunjukan responden yang mengalami Kanker Payudara berjumlah 58 dengan persentase sebesar (44,61%) sedangkan responden yang tidak mengalami Kanker Payudara berjumlah 72 dengan persentase (63,39%). Responden dengan Umur Ibu yang beresiko berjumlah 34 dengan persentase (26,15%) sedangkan responden dengan Umur Ibu yang tidak beresiko berjumlah 96 dengan persentase (73,85%). Responden dengan Status Perkawinan ibu yang berstatus kawin berjumlah 69 dengan persentase (53,07%) dan Status Perkawinan ibu yang berstatus tidak kawin berjumlah 61 dengan persentase (46,03%). Dari hasil uji Chi-Square didapatkan ada hubungan bermakna antara Umur Ibu dengan kejadian Kanker Payudara dimana p Value = 0,007, ada hubungan bermakna antara Status Perkawinan dengan kejadian Kanker Payudara dimana p Value = 0,030. Berdasarkan hasil penelitian, peneliti menyarankan upaya-upaya penyuluhan, pengetahuan tenaga medis dan meningkatkan mutu pelayanan kesehatan guna menurunkan angka kejadian kanker payudara.

Relationship of recent pregnancy and cytologic atypia in the contralateral breast of patients with breast cancer.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 149-149
Author(s):  
E. Revesz ◽  
C. M. Zalles ◽  
D. Ivancic ◽  
K. P. Bethke ◽  
N. M. Hansen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Scoring Systems ◽  
Needle Aspiration ◽  
Contralateral Breast ◽  
Cancer Risk Assessment ◽  
Breast Cancers ◽  
Breast Cancer Risk Assessment ◽  
Cytological Abnormalities ◽  
Cytological Features ◽  
A Prospective Study

149 Background: Although early parity protects against breast cancer later in life, it is a risk factor in the years following pregnancy, particularly when child-bearing is delayed. In a separate study, we have reported that these pregnancy-associated breast cancers (PABC) are more likely to be hormone receptor (HR) negative; we have previously found that random fine needle aspiration (rFNA) of the contralateral breast (CB) frequently have atypia in women with HR negative breast cancer. We now report an analysis of the cytological features of contralateral rFNA in relation to recent parity, with the goal of assessing cytological features which may be risk factors for PABC. Methods: Women with breast cancer undergoing surgery between 2006 and 2008 were enrolled in a prospective study of rFNA of the CB. Cytological analysis was performed on all the samples, using two scoring systems, Masood and Zalles (M and Z). Linear regression analyses were performed relating each score to interval from last pregnancy, stratified for parity, and adjusted for age. Results: Eighty-two patients had rFNA and cytologic analysis. The parous group’s (n=52) interval since last pregnancy was inversely correlated with the overall M score (p=0.034); pleomorphism and (p=0.047 and p=0.013 respectively). M score was also related to age at last pregnancy (p=0.026) as were pleomorphism and chromatin pattern (p=0.044 and 0.035 respectively). In the nulliparous group (n=30), there were no significant relationships between any of the cytological parameters or age. Conclusions: The CB of women with recent parity display specific cytological abnormalities that are related to risk of breast cancer, particularly HR negative breast cancer. This observation affords the opportunity to further evaluate rFNA as a tool for breast cancer risk assessment following pregnancy, and to identify molecular correlates of nuclear cytological abnormalities that may serve as targets for prevention of ER negative breast cancer.

Breast cancer grade and clinical benefit in patients with advanced breast cancer treated with an engineered whole tumor cell-targeted immunotherapy alone or in combination with checkpoint inhibition.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 3033-3033
Author(s):  
William Williams ◽  
Shaker R. Dakhil ◽  
Carmen Julia Calfa ◽  
Jarrod P. Holmes ◽  
Saveri Bhattacharya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Clinical Benefit ◽  
Cell Activity ◽  
Cancer Cell Line ◽  
Advanced Breast ◽  
Inoculation Site ◽  
Grade Ii ◽  
The Impact ◽  
Grade Iii

3033 Background: SV-BR-1 is a breast cancer cell line derived from a grade II (moderately differentiated) tumor. SV-BR-1 was transfected with the CSF2 gene (encoding GM-CSF) to form SV-BR-1-GM. SV-BR-1-GM expresses HLA class I & II antigens and has functional antigen-presenting cell activity, directly stimulating CD4+ T cells in an HLA-DR restricted fashion. The SV-BR-1-GM regimen consists of low-dose cyclophosphamide (300 mg/m2) to reduce immune suppression, intradermal inoculation with irradiated SV-BR-1-GM (20x106 cells divided into 4 sites) and interferon-α2b (10,000 IU into each inoculation site ~2 & 4 days later) to boost the response. Here, we evaluate the impact of tumor grade on clinical benefit following treatment with the SV-BR-1-GM regimen. Methods: Patients with advanced breast cancer were treated with either the SV-BR-1-GM regimen alone or with the SV-BR-1-GM regimen with pembrolizumab. For the SV-BR-1-GM regimen alone, cycles were administered every 2 weeks x 3 and then monthly, while combination with pembrolizumab (200 mg IV 1-5 days following SV-BR-1-GM inoculation) administered cycles every 3 weeks. Tumor restaging was every 6-12 weeks. Results: 33 patients were enrolled. The treatment was generally safe with inoculation site pruritis, erythema and induration the most common adverse events. 23 patients had grade III (poorly differentiated) tumors, 9 had grade II tumors and one had a grade I (well differentiated) tumor. None of the patients with grade III tumors exhibited clinical benefit. 7 patients with grade I/II tumors received the SV-BR-1-GM regimen alone, 2 received the SV-BR-1-GM regimen with pembrolizumab and 1 received both regimens. As noted in the Table, 7 patients experienced clinical benefit including all 3 patients treated in combination with pembrolizumab. This included 6 patients with stable disease and one with a partial response. Conclusions: The SV-BR-1-GM regimen with or without pembrolizumab appears safe and able to induce clinical benefit even in very heavily pre-treated patients with low or intermediate grade advanced breast cancer. Clinical trial information: NCT03328026 . [Table: see text]

scholarly journals A Prospective Study of Physical Activity and Breast Cancer Incidence in African-American Women

2014 ◽  
Vol 23 (11) ◽  
pp. 2522-2531 ◽  
Author(s):  
Lynn Rosenberg ◽  
Julie R. Palmer ◽  
Traci N. Bethea ◽  
Yulun Ban ◽  
Kristen Kipping-Ruane ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
African American ◽  
Prospective Study ◽  
African American Women ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
American Women ◽  
A Prospective Study
Sign in / Sign up

Export Citation Format

Share Document