scholarly journals Clear Cell Morphology in a Salivary Gland Tumor - Clearly a Morphological Dilemma

2020 ◽  
Vol 7 (12) ◽  
pp. C188-190
Author(s):  
Nisha J Marla ◽  
Poorni Bharathi T
Keyword(s):  
Salivary Gland ◽  
Cell Morphology ◽  
Clear Cell ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Salivary Gland Neoplasm ◽  
Immunohistochemical Markers ◽  
Eosinophilic Cytoplasm ◽  
Clear Cytoplasm ◽  
The Many

Primary salivary gland tumors with clear cell morphology comprise an uncommonly encountered subgroup of salivary gland neoplasm. Clear cell morphology is a known feature in both benign and malignant salivary gland tumors. Oncocytomas are uncommon tumors of the salivary gland. They have an abundance of mitochondria, which is manifested as granular eosinophilic cytoplasm by light microscopy with presence of cytoplasmic glycogen. Fixation artifact can impart cytoplasmic clearing and oncocytomas with a predominance of clear cytoplasm are labeled Clear cell oncocytomas. Accurate diagnosis of salivary gland tumors can be challenging because of the many diagnostic entities, extensive morphologic overlap, and the rarity of most tumor types. Here we report a case of Clear cell salivary oncoctyoma which was confirmed by Immunohistochemical markers by excluding morphological differential of Clear cell myoepithelioma.

scholarly journals Major Salivary Gland Tumors: A Clinicopathological Study

2013 ◽  
Vol 5 (1) ◽  
pp. 43-45
Author(s):  
Mohammad Wahiduzzaman ◽  
Nilima Barman ◽  
Tawfiqur Rahman ◽  
Mohammad Ehasun Uddin Khan ◽  
Mohammad Touhidul Islam ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Malignant Neoplasm ◽  
Salivary Gland Tumors ◽  
Medical College Hospital ◽  
Salivary Gland Neoplasm ◽  
Major Salivary Gland ◽  
College Hospital ◽  
Medical College ◽  
Parotid Neoplasm

Background: Major salivary gland tumors comprise a morphologically diverse group of rare tumors. The tumors also have variations in their clinicopathological profile related to racial and geographic differences. Objective: To find out the frequency of different types of major salivary gland neoplasm. Methodology: This cross sectional study was carried out on 50 patients having major salivary gland tumor in the departments of Otolaryngology of Bangabandhu Sheikh Mujib Medical University, Dhaka Medical College Hospital and Sir Salimullah Medical College Hospital from January 2010 to September 2010. Result: In this study, most cases occur in 5th decade. Incidence of malignant and benign parotid neoplasm was found 23.8% and 76.2% respectively. Benign and malignant tumors of submandibular gland were 50% in each group. No sublingual gland neoplasm was found in this group. Conclusion: Parotid gland was the most common site of origin of both benign and malignant tumours. Plemorphic adenoma was the most common benign salivary gland tumour and mucoepidermoid carcinoma was the most frequent malignant neoplasm. DOI: http://dx.doi.org/10.3329/jssmc.v5i1.16250 J Shaheed Suhrawardy Med Coll, 2013;5(1):43-45

Hyalinizing clear cell carcinoma of the nasopharynx operated by trans-oral and trans-palatal approach

2015 ◽  
Vol 129 (S2) ◽  
pp. S95-S97 ◽  
Author(s):  
T Nakashima ◽  
R Yasumatsu ◽  
M Yamauchi ◽  
S Toh ◽  
T Nakano ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Gland ◽  
Good Prognosis ◽  
Salivary Gland Neoplasm ◽  
Hyalinizing Clear Cell Carcinoma

AbstractBackground:Hyalinizing clear cell carcinoma is a rare minor salivary gland neoplasm. The treatment of choice is surgical resection with or without post-operative radiotherapy. This tumour often demonstrates a good prognosis.Case report:We report a case of hyalinizing clear cell carcinoma arising in the nasopharynx. A 27-year-old female presented with progressive hearing disturbance and tinnitus. On examination, an expansile mass was observed in her nasopharynx. Biopsy was performed and the pathology results returned as clear cell carcinoma.Results and conclusion:Surgical resection was performed trans-orally accompanied by trans-palatal approach. She has no recurrence during more than two years of follow up.

scholarly journals Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

2007 ◽  
Vol 18 (3) ◽  
pp. 192-197 ◽  
Author(s):  
Roberta Barroso Cavalcante ◽  
Fernanda Ferreira Lopes ◽  
Andréa Soares Ferreira ◽  
Roseana de Almeida Freitas ◽  
Lélia Batista de Souza
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Low Grade ◽  
Tubular Structures ◽  
Immunohistochemical Markers ◽  
Adenoid Cystic ◽  
Peripheral Cells ◽  
Diffuse Distribution ◽  
Labeling Pattern

Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.

scholarly journals Pattern of distribution of different salivary gland tumors; a retrospective study in NICRH, Dhaka

2016 ◽  
Vol 15 (1) ◽  
pp. 95-98
Author(s):  
Afroza Khanam ◽  
Gulshan Akhter ◽  
Md. Abdur Rahman
Keyword(s):  
Salivary Gland ◽  
Retrospective Study ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Major Salivary Gland ◽  
Gland Tumor ◽  
Minor Salivary Gland Tumors ◽  
Malignant Salivary Gland Tumors

Background: Salivary gland tumors are rare, generally benign and affect both major and minor salivary glands.Objective: To find out the pattern of distribution of different benign and malignant salivary gland epithelial tumors and their relation to age and sex in a tertiary care center in Bangladesh.Methodology: This is a retrospective study. Details of epithelial salivary gland tumors were obtained from department of ENT, National institute of cancer & research hospital (NICRH), Dhaka, Bangladesh from the period January 2009 to December 2012 (3 years).Result: A total number of 261 cases presenting with both benign and malignant salivary gland tumors were analyzed according to gender, age and histopathological findings. There were 130 (49.84%) males and 131 (50.19%) females with the male female ration of 1: 0.99. Age of study population ranged from 10 to 70 years with the mean age 40.78. Percentage of benign salivary gland tumors was 73.94% and malignant salivary gland tumor 26.05%. Among major salivary gland tumors, no sublingual tumors were found and parotid gland tumors were the commonest. Whereas, among minor salivary gland tumors palatal minor salivary tumors were common.Conclusion: Parotid gland was the most common site of origin of both benign and malignant salivary gland tumors. Histopathologically, pleomorphic adenoma was the most common benign salivary gland tumor and mucoepidermoid carcinoma was the most frequent malignant neoplasm. Adenoid cystic carcinoma was common minor salivary gland tumor.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.90-94

scholarly journals Primary Salivary Gland Tumors- A two years study at Nobel Medical College

2019 ◽  
Vol 2 (2) ◽  
pp. 234-238
Author(s):  
Niraj Nepal ◽  
Prabesh Kumar Choudhary ◽  
Manish Kumar Das ◽  
Meenakshi Basnet ◽  
Sagar Paudel
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Malignant Tumors ◽  
Age Groups ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Parotid Glands ◽  
Gland Tumor ◽  
Medical College

Introduction: Salivary gland tumors are a heterogeneous group of neoplasms that are relatively rare but represent a wide variety of both benign and malignant histopathologic subtypes. The aim of this study was to find out the histopathological distribution of primary salivary gland tumors and correlate fine needle aspiration cytology reports with histological findings.Materials and Methods: A total of 83 patients attending the otorhinolaryngology department with salivary gland tumors were enrolled in our study. The histopathological findings were reported and correlated with cytological findings.Results: The mean age of the patient with salivary tumors was 43.11 ± 13.02 years. Out of 83 cases, 3 (3.6%) patients were diagnosed as inflammatory lesions, 64 (77.1%) patients had benign salivary gland tumors and 16 (19.3%) of patients had malignant salivary glands tumors in histopathology. The sensitivity and specificity of FNAC in this series for detecting salivary gland malignancy were 68.8% and 98.5% respectively with an overall diagnostic accuracy of 92.8%. The most common salivary gland tumor was found to be pleomorphic adenoma (56.6%) and the most common malignant salivary gland tumor was found to be mucoepidermoid carcinoma (19.3%). The comparison of the incidence of salivary gland tumors in various age groups showed a statisticallysignificant difference (p=0.009).  Conclusions: Benign salivary tumors are more common than malignant tumors with the most common occurrence in parotid glands. Pleomorphic adenoma is the most common benign tumor whereas; mucoepidermoid carcinoma is the most common malignant tumor in patients visiting Nobel medical college.

The value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in salivary gland tumors.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17592-e17592
Author(s):  
Idris Yucel ◽  
Ozgur Kemal ◽  
Yasemin Kemal ◽  
Ayse Bel ◽  
Ugur Yildirim ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Malignant Tumors ◽  
Hematological Parameters ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Inflammatory Parameters ◽  
Tumor Group

e17592 Background: Salivary gland tumors are rare, comprising only 6 to 8 percent of head and neck neoplasms. Most of them are benign and commonly occur in the parotid gland. In the last decade elevated hematological inflammatory parameters like neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were identified as predictive and prognostic factors in various malignancies. The aim of this study was to evaluate the differences of preoperative of NLR and PLR levels in benign and malignant causes of salivary gland tumors. Methods: This retrospective study was made of a total of 133 patients with salivary gland tumors (age range: 17-89 years; 68 male and 65 female) who were treated between January 2006 and May 2016. Preoperative counts and levels of hematological parameters were obtained from the recorded computerized database in benign and malignant tumors. Results: NLR and PLR levels were significantly higher in the malignant salivary gland tumor group than the benign group( NLR: 0.66±1.3 vs 0.59±0.31 p=0.001, PLR: 160.3±85.7 vs 124.6±44.1 p=0.014). Conclusions: The results of the current study revealed the potential predicitve role of NLR and PLR in patients with salivary gland tumors. These cheap and easily available blood count parameters could be useful biomarkers in the future; but further investigations are needed to confirm our findings. [Table: see text]

scholarly journals Clinical and morphological features, immune profile of renal cell tumors with clear cytoplasm

2019 ◽  
Vol 15 (3) ◽  
pp. 126-131
Author(s):  
Yu. I. Osmanov ◽  
E. A. Kogan ◽  
L. O. Severgina ◽  
L. M. Rapoport ◽  
N. S. Aleksandrov ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Malignant Neoplasms ◽  
Kidney Tumors ◽  
Cell Renal Cell Carcinoma ◽  
Immunohistochemical Markers ◽  
Diagnostic Difficulties ◽  
Clear Cytoplasm

In the structure of oncological morbidity, renal cell carcinoma takes the 10th place among malignant neoplasms. The increase in incidence is observed from the age of 35–40 years and reaches a maximum at the age of 65–70 years. In terms of frequency of occurrence, clear cell renal cell carcinoma is ranked first among all kidney tumors. Meanwhile, due to the high heterogeneity of renal cell carcinomas with clear cytoplasm group, significant differential diagnostic difficulties arise in the morphological verification of these tumors. The article presents all nosological forms of kidney tumors with clear cytoplasm and provides a database of already known immunohistochemical markers for each nosological unit.

scholarly journals An Unusual Presentation of Clear Cell Odontogenic Carcinoma: Case Report

2016 ◽  
Vol 18 (1) ◽  
pp. 33
Author(s):  
Lida Velázquez DDS, MSc ◽  
Carlos Claudio DDS, MSc, PhD ◽  
Roger Pfuro
Keyword(s):  
Clear Cell ◽  
Distant Metastases ◽  
Unusual Presentation ◽  
Regional Lymph Nodes ◽  
Clear Cell Odontogenic Carcinoma ◽  
Eosinophilic Cytoplasm ◽  
Long Term Follow Up ◽  
Clear Cytoplasm ◽  
Odontogenic Carcinoma

Clear cell odontogenic carcinoma (CCOC) is a uncommon aggressive neoplasm of variable performance, which is primarily located in the mandibular anterior region, to a lesser extent in the maxilla, with prevalence in women between the fifth and seventh decades of life. Histologically it is constituted by networks of cells with clear cytoplasm mixed with cells containing eosinophilic cytoplasm rich in glycogen, surrounded by bands of collagen, you can make the local or distant metastases, highly recurrent, so it should include long-term follow-up patient and differentiated from other conditions with clear cell. The case of a male patient aged 52, with a mixed injury unusual presentation covering maxilla, zygomatic, orbital and right nasal cavity, without involvement of regional lymph nodes, no apparent metastases is reported. 

scholarly journals Proliferation PET/CT Imaging of Salivary Gland Tumor

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2065
Author(s):  
Ryogo Minamimoto
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Standardized Uptake Value ◽  
Ct Imaging ◽  
Salivary Gland Tumors ◽  
Parotid Carcinoma ◽  
Positron Emission ◽  
Pet Ct ◽  
Significant Difference ◽  
Malignant Salivary Gland Tumors

Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4′-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin’s tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor.

Sign in / Sign up

Export Citation Format

Share Document