scholarly journals Clinicohistologic Characteristics of Breast Cancer in Ghanaian Patients

2020 ◽  
Vol 7 (8) ◽  
pp. A385-393
Author(s):  
Leonard Derkyi-Kwarteng ◽  
Agyemang-Yeboah F ◽  
Ahenkorah Fondjo L ◽  
Gustav Imbeah E ◽  
Kafui Akakpo P

Background Breast cancer is the leading cause of cancer morbidity and mortality worldwide. The management and prognosis of breast cancer depend heavily on the different histologic and molecular biologic features of the tumour. The different histologic types describe the distinct growth patterns and cytological features of the tumour.   Methodology This is a retrospective study of archival breast cancer excision and mastectomy specimen at KBTH from 2012-2016. 729 cases were retrieved over the period and examined by two pathologists independently. Demography of the cases, tumour size, grade, histologic type, stage, mitosis, site of lesion etc. were entered into SPSS and analysed with chi-square done with P-value set at P < 0.05.   Results and Conclusion The mean age of presentation is 52.45 ± 12.75 years. The commonest histologic type of breast cancer is invasive carcinoma (NOS) forming (87%). Only 1.2% of male presented with breast cancer with the other percentage in females. Most (88%) of the tumours were greater than 5cm at the time of surgery. The tumours are of high grade (II and III) forming 88%. Seventy-eight percent of cases presented with late stage of the disease (≥ stage IIB). There was association between histologic type and vascular invasion (P < 0.000) and lymph node involvement (P = 0.010). Moreover, tumour size showed an association with tumour grade (P < 0.05). This study has shown that breast cancer among Ghanaian patients has a worse histologic type with poor tumour characteristics giving it poor prognosis.

Author(s):  
Rini Mayasari Rini Mayasari

ABSTRACT Breast cancer on the mark with the growth or uncontrolled growth of cells that are excessive. Factors affecting the incidence of breast cancer include maternal age, marital status, family history, hormone use, radiation, manarche, and obesity. The purpose of this study was to determine the relationship between Age and Marital Status of Mother with Breast Cancer incidence in the Installation Surgeon General Hospital Dr. Mohammad Hoesin Palembang in 2012. The study design was analytical descriptive with the approach in which the independent variables Cross Sectional Age Mother and Status Perkawianan and dependent variables in breast cancer incidence collected at the same time. The study population was all women who develop breast cancer in the Installation General Hospital Surgery Center Dr. Mohammad Hoesin Palembang in 2012 and samples taken by systematic random sampling with a sample of 130 respondents. The results of univariate analysis of data showed that respondents had breast cancer with a percentage of total 58 (44.61%) while respondents who had not had breast cancer totaled 72 by the percentage (63.39%). Respondents by Age Mothers who are at risk amounted to 34 by the percentage (26.15%) while respondents with Age Mothers who are not at risk amounted to 96 by the percentage (73.85%). Respondents by Marital Status is married and the mother who totaled 69 by the percentage (53.07%) and Marital Status with the status of unmarried women totaled 61 by the percentage (46.03%). Of Chi-Square test results found no significant relationship between Age Mothers with Breast Cancer event in which the p value = 0.007, no significant relationship between Marital Status in Breast Cancer event in which the p value = 0.030. Based on the results of the study, researchers suggest counseling efforts, medical knowledge and improve the quality of health services in order to reduce the incidence of breast cancer..   ABSTRAK Kanker payudara di tandai dengan pertumbuhan atau perkembangan tidak terkontrol dari sel-sel yang berlebihan. Faktor-faktor yang mempengaruhi kejadian kanker payudara antara lain umur ibu, status perkawinan, riwayat keluarga, penggunaan hormon, radiasi, manarche, dan obesitas. Tujuan penelitian ini adalah untuk mengetahui hubungan antara Umur Ibu dan Status Perkawinan dengan kejadian Kanker Payudara di Instalasi Bedah Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2012. Desain Penelitian ini adalah deskriptif analitik dengan pendekatan Cross Sectional dimana variabel independen Umur Ibu dan Status Perkawianan dan variabel dependen kejadian kanker payudara dikumpulkan dalam waktu yang bersamaan. Populasi penelitian ini adalah semua ibu yang menderita kanker payudara di Instalasi Bedah Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang Tahun 2012 dan sampel di ambil secara systematic random sampling dengan jumlah sampel 130 responden. Hasil analisis univariat data menunjukan responden yang mengalami Kanker Payudara berjumlah 58 dengan persentase sebesar (44,61%) sedangkan responden yang tidak mengalami Kanker Payudara berjumlah 72 dengan persentase (63,39%). Responden dengan Umur Ibu yang beresiko berjumlah 34 dengan persentase (26,15%) sedangkan responden dengan Umur Ibu yang tidak beresiko berjumlah 96 dengan persentase (73,85%). Responden dengan Status Perkawinan ibu yang berstatus kawin berjumlah 69 dengan persentase (53,07%) dan Status Perkawinan ibu yang berstatus tidak kawin berjumlah 61 dengan persentase (46,03%). Dari hasil uji Chi-Square didapatkan ada hubungan bermakna antara Umur Ibu dengan kejadian Kanker Payudara dimana p Value = 0,007, ada hubungan bermakna antara Status Perkawinan dengan kejadian Kanker Payudara dimana p Value = 0,030. Berdasarkan hasil penelitian, peneliti menyarankan upaya-upaya penyuluhan, pengetahuan tenaga medis dan meningkatkan mutu pelayanan kesehatan guna menurunkan angka kejadian kanker payudara.


2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 12053-12053
Author(s):  
Marisa C. Weiss ◽  
Stephanie Kjelstrom ◽  
Meghan Buckley ◽  
Adam Leitenberger ◽  
Melissa Jenkins ◽  
...  

12053 Background: A current cancer diagnosis is a risk factor for serious COVID-19 complications (CDC). In addition, the pandemic has caused major disruptions in medical care and support networks, resulting in treatment delays, limited access to doctors, worsening health disparities, social isolation; and driving higher utilization of telemedicine and online resources. Breastcancer.org has experienced a sustained surge of new and repeat users seeking urgent information and support. To better understand these unmet needs, we conducted a survey of the Breastcancer.org Community. Methods: Members of the Breastcancer.org Community were invited to complete a survey on the effects of the COVID-19 pandemic on their breast cancer care, including questions on demographics, comorbidities (including lung, heart, liver and kidney disease, asthma, diabetes, obesity, and other chronic health conditions); care delays, anxiety due to COVID-related care delays, use of telemedicine, and satisfaction with care during COVID. The survey was conducted between 4/27/2020-6/1/2020 using Survey Monkey. Results were tabulated and compared by chi square test. A p-value of 0.05 is considered significant. Data were analyzed using Stata 16.0 (Stata Corp., Inc, College Station, TX). Results: Our analysis included 568 breast cancer patients of whom 44% had ≥1 other comorbidities associated with serious COVID-19 complications (per CDC) and 37% had moderate to extreme anxiety about contracting COVID. This anxiety increased with the number of comorbidities (p=0.021), age (p=0.040), and with a current breast cancer diagnosis (p=0.011) (see table). Anxiety was significantly higher in those currently diagnosed, ≥65, or with ≥3 other comorbidities, compared to those diagnosed in the past, age <44, or without other comorbidities. Conclusions: Our survey reveals that COVID-related anxiety is prevalent at any age regardless of overall health status, but it increased with the number of other comorbidities, older age, and a current breast cancer diagnosis. Thus, reported anxiety is proportional to the risk of developing serious complications from COVID. Current breast cancer patients of all ages—especially with other comorbidities—require emotional support, safe access to their providers, and prioritization for vaccination.[Table: see text]


2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 81-81 ◽  
Author(s):  
Hong-Seok Han ◽  
Hyun-June Paik ◽  
Jai Min Ryu ◽  
Sungmin Park ◽  
Ha Woo Yi ◽  
...  

81 Background: As known, larger tumor size and more extensive lymph node (LN) involvement have been considered an independent factor for poor prognosis of breast cancer. We evaluated if very small tumor size may be a factor of worse prognosis compared to larger tumor in small sized breast cancer with LN involvement. Methods: A retrospective analysis was made in a single center of all 1400 patients with small (below 2cm, T1) sized and LN involved (N1~N3) breast cancer without metastasis diagnosed between 2004 and 2014. Their ages ranged from 23 to 88 years (mean age 49.1 ± 9.9 years) and mean follow-up was 31 months. All patients were performed with surgery including axillary LN dissection without neo-adjuvant chemotherapy. We subdivided their tumor size to 4 group (T1m, T1a, T1b and T1c) grading by 7th AJCC cancer staging. The number of patients in each group is as follows: T1m = 17, T1a = 63, T1b = 214, T1c = 1106. The specific features related to mortality were analyzed according to the minor groups and they were compared with one another by Chi-square test and Kaplan-Meier analysis. Results: Total expired patients were 39 (2.8%) and the number (the rate in each group) of the minor groups is as follows: T1m = 1 (5.9%), T1a = 1 (1.6%), T1b = 7 (3.3%), T1c = 22 (2.0%). Overall survival of smaller sized tumor groups ( ≤ 1cm, T1m+T1a+T1b) are significantly decreased than the other larger sized group T1c in T1N1 staged patients (p = 0.004). There are significant differences in estrogen receptor, progesterone receptor, nuclear grade, recurrence among the 4 minor groups in whole patients group. In the analysis of nuclear grade, the results show higher grade in T1m than T1a, T1m than T1b, T1b than T1c. Especially, recurrence of T1m is significantly more frequent than T1a (17.6% vs 3.2%, P = 0.03) or T1b (17.6% vs 4.2%, p = 0.016). Conclusions: In conclusion, this study indicates smaller sized tumor with LN involvement can progress worse compared to larger tumor. This result supports very small size can be another predictive factor for prognosis in small sized breast cancer with LN involvement.


2017 ◽  
Vol 2 (3) ◽  
pp. 47
Author(s):  
Nayi Zongo ◽  
Sanon/Lompo Marthe Sandrine ◽  
Bambara H. Aboubacar ◽  
Soma Chantal ◽  
Bambara Augustin Tozoula ◽  
...  

The Objective was to assess the knowledge and practical abilities of final year nursing and midwifery students in health schools of Ouagadougou relating to screening and early diagnosis of breast cancer. This is a cross-sectional, prospective and descriptive observational study conducted from 1st November 2014 to 31st January 2015. A sample of 403 students was used for this study. Data were collected using an individual questionaire and were typed on Epi data and then analyzed on SPSS software. Chi-square tests were used to compare the different proportions. The difference is considered to be significant if p value < 0.05. Three hundred and ninety nine students filled the questionnaire, i.e. a rate of non-respondents of 1%. All students were aware of the existence of breast cancer. The media (47.8%) was the main source of information. The level of knowledge of students was satisfactory with frequencies of 83.9% for risk factors; 91.6% for clinical signs; 83.4 % for screening methods and 88.1% for therapeutic terms of breast cancers. However, focus should be put on the teaching of cancerology and the supervision of students during internship, must be reinforced. These results attest that the level of students in the knowledge and practical abilities concerning screening and early diagnosis of breast cancer is satisfactory.


2019 ◽  
Vol 13 (2) ◽  
pp. 172-183
Author(s):  
Nurhayati Nurhayati ◽  
Zaenal Arifin ◽  
Hardono Hardono

ABSTRACT: THE INCIDENCE OF BREAST CANCER IN LAMPUNG INDONESIA: A RETROSPECTIVE COHORT ANALYSISBackground: Cancer is the second leading cause of death in the world, the highest type of cancer in women in the world is breast cancer with an incidence of 38 per 100,000 women. In Indonesia by 2012 the incidence of breast cancer in Indonesia is 40 per 100,000 women. The incidence of breast cancer in the city of Bandar Lampung is 80 per 100,000 population.Purpose : Knowing risk factors incidence of breast cancer in the Foundation of Cancer Indonesia in Bandar Lampung 2017.Methods: The quantitative and observational research with case control design. The population of this study were all patients who had done counseling and examination by Cancer counseling institute of Indonesia during the period of research as much as 691 respondent, with the required number of samples 126 rspondent. Bivariate analysis was done with chi square (X2), while multivariate analysis using multiple linear logistic regression .Results: The risk factors such as menarche (p-value = 0.002), parity (p-value = 0,018), breastfeeding (p-value = 0,000) and duration of contraceptive use (p-value = 0, 02), while factors unrelated to breast cancer were family history (p-value = 0.112) and age (value = 0.357).Conclusion: The most influential variable on the incidence of breast cancer is the variable duration of contraceptive use. For health workers need to do counseling about breast cancer risk factors. Women of childbearing age should use non-hormonal family planning, when using a type of hormonal contraception need to be consult with local health workers and avoid births that are too frequent.Keywords: Factor Analysis, Breast Cancer, Breast Cancer History, Age of Menarche, Age, Parity, Breastfeeding Status, Hormonal Contraception.Pendahuluan : Kanker adalah penyebab kematian nomor dua di dunia, jenis kanker tertinggi pada wanita di dunia adalah kanker payudara dengan insidensi 38 per 100.000 wanita. Di Indonesia pada tahun 2012, insiden kanker payudara di Indonesia adalah 40 per 100.000 wanita. Angka kejadian kanker payudara di kota Bandar Lampung adalah 80 per 100.000 penduduk.Tujuan: Diketahui faktor-faktor risiko kejadian kanker payudara di Yayasan Kanker Indonesia di Bandar Lampung 2017.Metode: Jenis penelitian yang akan digunakan peneliti adalah kuantitatif. Desain penelitian yang digunakan adalah penelitian observasional dengan desain case control. Populasi penelitian ini adalah semua pasien yang telah melakukan konseling dan pemeriksaan oleh lembaga konseling kanker Indonesia selama periode penelitian sebanyak 691 orang, dengan jumlah sampel yang dibutuhkan 126 orang. Analisis bivariat dilakukan dengan chi square (X2), sedangkan analisis multivariat menggunakan regresi logistik linier berganda.Hasil: faktor risiko kanker payudara seperti menarche (p-value = 0,002), paritas (p-value = 0,018), menyusui (p-value = 0,000) dan durasi penggunaan kontrasepsi (p-value = 0, 02), sedangkan faktor-faktor yang tidak berhubungan dengan kanker payudara adalah riwayat keluarga (p-value = 0,112) dan usia (nilai = 0,357).Simpulan: Variabel yang paling berpengaruh pada kejadian kanker payudara adalah variabel lamanya penggunaan kontrasepsi. Untuk tenaga kesehatan perlu melakukan penyuluhan tentang faktor risiko kanker payudara. Untuk WUS, sebaiknya menggunakan KB non hormonal, jika terpaksa menggunakan jenis kontrasepsi hormonal sebaiknya dikonsultasikan terlebih dahulu dengan petugas kesehatan setempat dan hindari kelahiran yang terlalu rapat.


2018 ◽  
Vol 04 (02) ◽  
pp. 061-068
Author(s):  
Shazima Sheereen ◽  
Flora Lobo ◽  
Barun Kumar ◽  
Manoj S. ◽  
Santosh G. ◽  
...  

AbstractThe histopathological interpretation of a tumor still remains the gold standard for diagnosis and deciding the type of therapy. Furthermore, in the context of chemo-radio-therapies often leading to prominent cytological and stromal changes in the tumor, histopathological interpretation during treatment, thus, becomes all the more important in correctly diagnosing and grading the tumor for an effective and planned regimen of the therapy increasing prognosis and chances of survival of the affected patients. The aim of the present study was to evaluate such cytological and stromal changes rendered by the therapy during treatment in breast cancer cases. The present study was conducted over a period of 4 years from January 2014 to June 2017 at Kasturba Medical College, Mangalore, Karnataka, India wherein the clinical and histopathological details were collected for a total of 39 breast carcinoma cases during and post-therapy. Statistical analysis was done using IBM SPSS statistics 17 (Chicago, USA). Various morphological features were analyzed for their frequency and were compared with the final diagnosis using Chi-square value (χ2), paired t-test and Fischer's test. p-value < 0.05 was considered to be statistically significant. The results of the present study revealed that 32 of the 39 breast carcinoma cases changed their grades during the course of therapy (p-value < 0.05). The fundamental manifestation of the effect of therapy was an obvious decrease in tumor cellularity. Intracellular changes commonly noted after chemotherapy included nuclear enlargement, hyperchromasia and an increased N:C ratio which were found in upto 85% of the cases followed by presence of prominent nucleoli and karyorrhexis/karyolysis. The predominant stromal changes seen post-therapy included necrosis (74.4%), fibrosis (64.1%), desmoplasia (59%) and degenerative changes (33.3%). Breast cancer therapy causes morphological alterations in the cancerous as well as the surrounding healthy tissue. The histopathological interpretation in such cases, thus, requires a thorough knowledge of the cytological and stromal changes rendered by the therapy.


2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e11506-e11506
Author(s):  
Sanjay P Deshmukh ◽  
Anupama Dutt Mane

e11506 Background: The incidence of breast cancer is rising in India. It presents at a younger age in Indian population as compared to the western countries. Methods: This is a retrospective review of all breast cancer patients less than 40 years of age treated in single tertiary care center from June 2006 to June 2011. The aim was to assess the factors that may influence clinical outcome and prognosis including demographics, clinical characteristics, surgical and pathological findings and the treatment given. Clinical data was collected from medical records and histopathology reports. Independent variables like age, stage at presentation, surgery type, chemotherapy, radiation, tumour size, grade, nodal status, no. of positive nodes, perinodal extension, lymphovascular extension, ER, PR and Her2 neu were analysed. Results: Out of a total of 613 patients, 91 were under 40 years of age, corresponding to a prevalence of 14.8%. Median age was 35 years with the youngest being 23 years old. Maximum patients were in the age group of 36-40 years. Lymphovascular emboli was positive in 42 patients (48.8%) and perinodal extension was positive in 36 patients (41.8%). 30 patients(34.8%) had ER positivity, while 39 patients (45.3%) had PR positivity. Her 2 neu receptors were positive in 20 patients (23.2%). 39 patients were triple negative (45.3%). The median follow up period for all the patients was 28 months with the DFS being 76.1% and OS being 88.3%. In univariate analysis, factors significantly associated with survival were stage at presentation (p value- 0.026), presence of lymhovascular emboli (p value- 0.019) and presence of perinodal extension (p value- 0.007 ).Grade of the tumour also correlated with survival , however it was not statistically significant (p value- 0.086). Statistical analysis was done with SPSS 17. Conclusions: The incidence of breast cancer in younger women in India is high with increased number of triple negative patients. Overall survival is quite similar to that of the western population. Longer follow up and more studies are required to confirm this finding.


2020 ◽  
Vol 27 (2) ◽  
pp. 27-35
Author(s):  
Harahsheh , Hend M. ◽  
Al-Bdour , Bilal A. ◽  
Ayyad , Rawan M. ◽  
Al-Habahbeh , Laith M. ◽  
AL Waqfi , Ola M.

2018 ◽  
Vol 6 (1) ◽  
pp. 9-17
Author(s):  
Avisak Bhattacharjee ◽  
AFM Anwar Hossain ◽  
Shahanara Yeasmin ◽  
Tangera Akter

Background: Molecular subtype determination of breast carcinoma is still an enigma in our perspective. We are far behind the genetic analysis but immunohistochemistry is commonly ensured now a days.Objective: To observe the incidence, epidemiological and clinico-pathological status of different molecular subtypes of breast cancer patients.Materials and method: At first 141 patients were enrolled by purposive sampling. Among them 138 patients were finalized according to the eligibility criteria. A pre-structured, peer reviewed, properly tested, interview and observation based data collection sheet was prepared. Data regarding epidemiological profile, clinical profile and histopathological profile were collected, compiled, edited and analyzed. Mean, frequency, chi-square test were adopted for analysis. Statistics were found significant at <0.05.Results: Mean age of patients was 43.20±9.69 years. Mean BMI was 25.26±13.47. Out of 138 patients, only 4.34% had positive family history, 64.49% and 35.5% had left and right sided breast cancer respectively, 65.2% had tumour size 2-5cm which was followed by 27.53% cases with >5cm sized tumour in maximum diameter. Among the five major molecular subtypes both luminal A and triple negative breast cancer (TNBC) showed high prevalence (27.53%). Association of molecular subtypes with histopathological grading revealed TNBC was the most aggressive among all molecular subtypes. Axillary lymphadenopathy was present in almost all cases.Conclusion: Luminal A and TNBC were positive in most of the cases whereas TNBC showed higher association with advance histopathological grade. Clinical status was almost similar in all subtypes.Delta Med Col J. Jan 2018 6(1): 9-17


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