Role of CT Colonographyin the Evaluation of Colorectal Carcinoma

2019 ◽  
Vol 7 (2) ◽  
pp. 36-40
Author(s):  
Sabari Arasu P ◽  
◽  
Arun Kumar S ◽  
Kaviyarasy T ◽  
Dhivya R ◽  
...  
Keyword(s):  
Colorectal Carcinoma

scholarly journals Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Angelica Canossi ◽  
Anna Aureli ◽  
Tiziana Del Beato ◽  
Piero Rossi ◽  
Luana Franceschilli ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Genetic Risk ◽  
Clinical Stage

scholarly journals Bioinformatic Analysis: The Role of LINC00634 in Colorectal Carcinoma

2021 ◽  
Author(s):  
Fang Liu ◽  
Fengyihuan Fu ◽  
Yuqiang Nie
Keyword(s):  
Esophageal Cancer ◽  
Regression Analysis ◽  
Prognostic Factors ◽  
Colorectal Carcinoma ◽  
Roc Curve ◽  
Cox Regression ◽  
Survival Outcomes ◽  
Immune Infiltration ◽  
The Relationship

Abstract Background: LINC00634 is highly expressed in esophageal cancer, and its depletion can suppress the viability and induce the apoptosis of esophageal cancer cells. However, there is a lack of studies that examine the relationship between LINC00634 expression and the clinicopathological features, survival outcomes, prognostic factors and tumor immune cell infiltration of colorectal carcinoma (CRC) patients.Objective: We aim at investigating the role of LINC00634 in colorectal carcinoma.Methods: We obtained data from the TCGA (The Cancer Genome Atlas) public database, GTEx (Genotype-Tissue Expression) database and clinical samples. Wilcoxon rank-sum test, Kruskal-Wallis test and logistic regression analysis were employed to assess the relationship between LINC00634 expression and the clinicopathological characteristics of CRC patients. Receiver operating characteristic (ROC) curve was constructed to evaluate the ability of LINC00634 for distinguishing between CRC patients and normal subjects based on the area under the curve (AUC) score. Univariate and multivariate analyses were conducted to evaluate the association between prognostic factors and survival outcomes. Kaplan-Meier curves and Cox regression analysis were employed to determine the contribution of LINC00634 expression to the prognosis of colorectal carcinoma patients. Immune infiltration analysis and Gene Set Enrichment Analysis (GSEA) were conducted to identify the significantly involved functions of LINC00634. Finally, a nomogram was constructed for internal verification based on the Cox regression data.Results: The expression of LINC00634 was upregulated in CRC patients, and markedly associated with N stage, residual tumor, pathological stage, and overall survival (OS) event. ROC curve showed that LINC00634 had strong diagnostic and prognostic abilities (AUC=0.74). The high expression of LINC00634 could predict poor disease specific survival (DSS; P=0.008) and poor overroll survival (OS;P<0.01). The expression of LINC00634 was independently associated with OS in CRC patients (P=0.019). GSEA and immune infiltration analysis demonstrated that LINC00634 expression was involved in gene transcription, epigenetic regulation and the functions of certain types of immune infiltrating cells. The c-index of the nomogram was 0.772 (95％CI: 0.744-0.799).Conclusions: Our study reveals that LINC00634 can serve as a potential prognostic biomarker for CRC patients.

Evaluation of the role of CD44 as a cancer stem cell marker in colorectal carcinoma: immunohistochemical study

2017 ◽  
Vol 30 (1) ◽  
pp. 174 ◽  
Author(s):  
AyatG Lasheen ◽  
NanisS Holah ◽  
HayamA Aiad ◽  
NancyY Asaad ◽  
EnasA. B. Elkhouly
Keyword(s):  
Stem Cell ◽  
Colorectal Carcinoma ◽  
Cancer Stem Cell ◽  
Immunohistochemical Study ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

The Role of Serum Carcinoembryonic Antigen (CEA) in the Management of Patients with Colorectal Carcinoma: The Experience of the Istituto Tumori of Milan

1992 ◽  
Vol 7 (3) ◽  
pp. 167-170 ◽  
Author(s):  
E. Seregni ◽  
E. Bombardieri ◽  
A. Bogni ◽  
F. Crippa ◽  
E. de Jager ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Clinical Management ◽  
Curative Resection ◽  
Recurrent Disease ◽  
Clinical Stage ◽  
Serum Levels ◽  
Serum Carcinoembryonic Antigen ◽  
Positive Results

CEA determination has attained an important role in the clinical management of patients with tumors of the colorectal tract. In this paper the experience of the Istituto Tumori of Milan is reviewed and the results are discussed. Three hundred and thirty-six patients were followed after curative resection of colorectal carcinoma. The follow-up period was 15 years, from January 1975 to December 1990 (global follow-up 1358 years). In the course of follow-up 136 patients developed recurrent disease. The number of CEA determinations for each patient ranged from 1 to 37 (mean 8, total 3330). CEA levels of presurgical patients were related to the clinical stage. Among patients who developed recurrences 61% showed an increase in CEA serum levels. In 200 patients with a negative follow-up we observed only 15 cases of false-positive results.

Abstract 1521: Role of the guanylate-binding-protein 1 (GBP-1) in immunoediting of colorectal carcinoma.

2013 ◽  
Author(s):  
Nathalie Britzen-Laurent ◽  
Karoline Lipnik ◽  
Matthias Ocker ◽  
Elisabeth Naschberger ◽  
Vera Schellerer ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Binding Protein ◽  
Guanylate Binding Protein

Abstract 5162: Role of IFN-gamma-activation of distinct tumor and stromal cell populations in colorectal carcinoma pathogenesis

2019 ◽  
Author(s):  
Nathalie Britzen-Laurent ◽  
Wei Guo ◽  
Victoria Langer ◽  
Svetlana Khoziainova ◽  
Thomas Weisenburger ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Stromal Cell ◽  
Cell Populations ◽  
Gamma Activation ◽  
Ifn Gamma

Abstract C34: The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells

2011 ◽  
Author(s):  
Yen-Chou Chen ◽  
Ching Huai Ko ◽  
Shing Chuan Shen ◽  
Liang Yo Yang
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Cox 2 ◽  
Induced Apoptosis
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