scholarly journals Assessing Role of Oral Glutamine Supplementation in Radiation Induced Oral Mucositis in Head and Neck Cancers

2018 ◽  
Vol 4 (2) ◽  
Author(s):  
Ashok Kumar Diwan ◽  
Subeera Khan
Keyword(s):  
Head And Neck ◽  
Oral Mucositis ◽  
Head And Neck Cancers ◽  
Glutamine Supplementation ◽  
Radiation Induced

Benzydamine for prophylaxis of radiation induced oral mucositis in head and neck cancers: Double-blind clinical trial

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 9042-9042
Author(s):  
S. Kamian
Keyword(s):  
Placebo Group ◽  
Head And Neck ◽  
Oral Mucositis ◽  
Treated Group ◽  
Head And Neck Cancers ◽  
Control Group ◽  
Oral Rinse ◽  
Neck Tumors ◽  
Radiation Induced ◽  
Grade 3

9042 Background: Oral mucositis is one of the most common adverse effects of radiotherapy in head and neck tumors. We determined the efficacy of oral rinse benzydamine in prevention of radiation induced mucositis. Methods: Patients with head and neck cancers were enrolled in a randomize, placebo-controlled clinical trail to receive either benzydamine or placebo. All the cases received at least 50 Gy radiation to the oral cavity and oropharyngeal areas. The end points were comparison of highest grade of mucositis at the end of radiotherapy, frequency of grade 2 or more, the interval days to establishing grade 2 in the groups. Results: 100 patients with head and neck cancers were randomized in this trail. At the end of the study, 19 patients were excluded of the analysis due to minor side effects of drug, or stopping the radiotherapy. In 39 cases in the treated group, the frequency of mucositis grade 3 or more was 43.6% (17 cases) in contrast to 78.6% (33 cases) in 42 cases in the placebo group, which was significant (p=0.001). Mucositis grade 3 or more was 2.6 times frequent in placebo group (CI=95%, relative risk=1.38–5). At the end of RT, at least 42% of the treated group had mucositis grade 3 or more in contrast to at least 76% in the control group which was statistically significant. Intensity of mucositis was increased up to forth week of treatment in both groups to grade 2. In the treated group the grade of mucositis was approximately constant to the end of therapy; but in the control group it raised to grade 3 (p<0.001). The highest grade of mucositis during the treatment time was significantly different between two groups (p=0.049). The median interval days of establishing grade 2 mucositis was 3.6 days sooner in the placebo group (p=0.12). Conclusions: According to these results it seems that oral rinse benzydamine was effective, safe, and well tolerated for prophylactic treatment of radiation-induced oral mucositis in head and neck tumors. [Table: see text]

scholarly journals 195 The Application of Radiomics in Laryngeal Cancer: The Forgotten Cohort

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
A Rajgor ◽  
A McQueen ◽  
T Ali ◽  
E Aboagye ◽  
B Obara ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Head And Neck ◽  
Laryngeal Cancer ◽  
Prognostic Value ◽  
Head And Neck Cancers ◽  
High Dimensional ◽  
Naked Eye ◽  
Online Databases ◽  
Novel Method

Abstract Background Radiomics is a novel method of extracting data from medical images that is difficult to visualise through the naked eye. This technique transforms digital images that hold information on pathology into high-dimensional-data for analysis. Radiomics has the potential to enhance laryngeal cancer care and to date, has shown promise in various other specialties. Aim The aim of this review is to summarise the applications of this technique to laryngeal cancer and potential future benefits. Method A comprehensive systematic review-informed search of the MEDLINE and EMBASE online databases was undertaken. Keywords ‘laryngeal cancer’ OR ‘larynx’ OR ‘larynx cancer’ OR ‘head and neck cancer’ were combined with ‘radiomic’ OR ‘signature’ OR ‘machine learning’ OR ‘artificial intelligence’. Additional articles were obtained from bibliographies using the ‘snowball method’. Results Seventeen articles were identified that evaluated the role of radiomics in laryngeal cancer. Two studies affirmed the value of radiomics in improving the accuracy of staging, whilst fifteen studies highlighted the potential prognostic value of radiomics in laryngeal cancer. Twelve (of thirteen) studies incorporated an array of different head and neck cancers in the analysis and only one study assessed laryngeal cancer exclusively. Conclusions Literature to date has various limitations including, small and heterogeneous cohorts incorporating patients with head and neck cancers of distinct anatomical subsites and stages. The lack of uniform data on solely laryngeal cancer and radiomics means drawing conclusions is difficult, although these studies have affirmed its value. Further large prospective studies exclusively in laryngeal cancer are required to unlock its true potential.

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