scholarly journals Investigation of non-canonical terpene biosynthesis

2021 ◽  
Author(s):  
◽  
Laura Drummond
Keyword(s):  
Natural Products ◽  
Structural Material ◽  
Production Systems ◽  
Terpene Biosynthesis ◽  
The Creation ◽  
Fragrance Compounds

Terpenes are one of the largest and most diverse class of natural products, produced by organisms from all kingdoms of life and with important applications in the pharma, flavor and fragrance industries. Well-known examples of terpenes are the pharmaceuticals artemisinin and taxol, the flavor and fragrance compounds menthol, santalol and sclareol, the structural material polyisoprene and the biofuel precursor farnesene. The methods and results presented in this work offer a variety of ways to modify terpene precursors for the creation of new terpene molecules. The application of these methodologies in well-established production systems could lead to the production of new substances, with applications in the industrial fields of pharmaceuticals, flavors and fragrances, and biofuels.

THE CONCEPT OF COMPETITIVE VALUE CHAINS IN PRODUCTION SYSTEMS AS AN INSTITUTIONAL STRUCTURE OPERATING ON NETWORK PRINCIPLES

2019 ◽  
Vol 6 (3) ◽  
pp. 61-67
Author(s):  
Niyaz Mustjakimovich Abdikeev ◽  
Anton Alekseevich Losev ◽  
Andrey Ivanovich Gaydamaka
Keyword(s):  
Business Processes ◽  
Production Systems ◽  
Institutional Structure ◽  
Cognitive Models ◽  
Value Chains ◽  
High Tech ◽  
Practical Implementation ◽  
Digital Platform ◽  
Software Product ◽  
The Creation

The Concept of competitive value chains in production systems, as an institutional structure operating on network principles, was the impetus for the development of a system of models of inter-industry digital platform for the management and optimization of cooperation of high-tech network production systems. The article describes the ways of integration into business processes of production systems of simulation and cognitive models. The practical implementation of the system of these models is a separate software product - an interdisciplinary digital platform for participants in the creation of new high-tech products and their components.

Inherent dynamical preferences in carbocation rearrangements leading to terpene natural products

2013 ◽  
Vol 85 (10) ◽  
pp. 1949-1957 ◽  
Author(s):  
Ryan P. Pemberton ◽  
Young J. Hong ◽  
Dean J. Tantillo
Keyword(s):  
Natural Products ◽  
Quantum Chemical ◽  
Chemical Dynamics ◽  
Terpene Biosynthesis ◽  
Bare Bones

An introduction to the application of quantum chemical dynamics calculations to mechanistic problems in the field of terpene biosynthesis is provided. A bare bones introduction to the fundamentals of chemical dynamics is followed by a brief account of previous applications to terpene-forming carbocation reactions, a discussion of questions in this field that dynamics calculations may help answer, and a description of current problems to which dynamics calculations are being applied.

Green Synthesis, Characterization and Applications of ZnO Nanoparticles—A Review

2019 ◽  
Vol 11 (11) ◽  
pp. 1009-1022
Author(s):  
Sukanta Pal ◽  
Sourav Mondal ◽  
Prasanta Pal ◽  
Jayanta Maity
Keyword(s):  
Zinc Oxide ◽  
Natural Products ◽  
Green Synthesis ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Stem Bark ◽  
Oxide Nanoparticles ◽  
Nanoscience And Nanotechnology ◽  
The Creation

Nanoscience and nanotechnology manage the creation, running, and utilization of the materials having the nanoscale measurement. In this audit, for the most part, centers on the green amalgamation of zinc oxide nanoparticles utilizing diverse plants parts (leaf, bloom, natural products, root and stem bark), microscopic organisms, and growth with logical name, family name, regular name and its portrayal, size, and state of the nanoparticles, and different applications. Different significances and utilization of the green incorporated ZnO nanoparticles in the photocatalyst and antibacterial movements were also examined.

From Production Systems to Learning Systems: Lessons from Japan

1993 ◽  
Vol 25 (6) ◽  
pp. 797-815 ◽  
Author(s):  
J Patchell
Keyword(s):  
Production Systems ◽  
Governance Structure ◽  
Division Of Labour ◽  
Learning Systems ◽  
Social Division ◽  
Goods And Services ◽  
Trade Offs ◽  
The Social ◽  
External Governance ◽  
The Creation

The need to advance the conventional understanding of production systems as fixed flows of goods and services to dynamic systems based on learning is discussed. The theory advanced is based on research on the Japanese robot industry. The paper opens with a discussion of the meaning of flexibility in a dynamic economy to expose the social division of labour as the foundation of the creation and evolution of production systems. Production systems are established to obtain the scale and scope economies offered by the independent firms of the social division of labour. The necessity to organize production requires the creation of some type of an internal or external governance structure. The Japanese have developed a social technology that resolves the transaction cost trade-offs confronting North American industry between internal and external governance structures. Asanuma's relation-specific skill is discussed as the crux for comprehending the shift from production systems to learning systems.

scholarly journals Cyberphysical Approach to the Creation, Operation and Improvement of Transport and Production Systems

2020 ◽  
pp. 331-343
Author(s):  
Viktor Aulin ◽  
◽  
Andrey Grinkiv ◽  
Artem Holovatyi ◽  
◽  
...  
Keyword(s):  
Cloud Computing ◽  
Internet Of Things ◽  
Embedded Systems ◽  
Occupational Safety ◽  
Production Systems ◽  
The Internet ◽  
Technical Service ◽  
The Creation ◽  
Specific Implementation ◽  
The Internet Of Things

The content of the cyberphysical approach to the creation, functioning and improvement of transport and production systems is analyzed. It was found out how, on the basis of the approach, cyberphysical transport and production systems are created as the integration of special technologies of the Internet of Things; embedded systems; ubiquitous and cloud computing. It was revealed that cyberphysical transport and production systems have a trinitarian concept and are defined by three entities: communication, computation and control, which unites information. It is determined that the main functions of cyberphysical transport and production systems are: information processing, intelligent communications, performance and process control. A component model of such a system has been built, which includes two groups of components - evolutionary and technological. The evolutionary group of components includes subsystems: digital; integrated; robotic, intelligent distributed. These components are a kind of basis for the presence of prerequisites for the creation of transport and production systems. It is noted that the technology group of components is the basis for concrete implementations of the Internet of Things, embedded systems and ubiquitous and cloud computing. A cyberphysical system of technical service is proposed as a specific implementation of cyberphysical transport and production systems. It was determined that the modes of the proposed functional cyber system are: high adaptability; an appropriate level of efficiency; intelligence of management; high level of reliability; the use of a new on-net online simulation type; using a new type of self-verifying models; internal online optimization, etc. It is shown that the presence of intelligent models in the cyberphysical model of technical service makes the system resistant to cyberattacks and increases the degree of safety when ensuring traffic in transport and the development of an occupational safety system during maintenance and repair operations.

scholarly journals Making drugs out of sunlight and ‘thin air’: an emerging synergy of synthetic biology and natural product chemistry

2020 ◽  
Vol 42 (4) ◽  
pp. 34-39
Author(s):  
Michael J. Stephenson ◽  
Anne Osbourn
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Natural Product ◽  
Large Scale ◽  
Production Systems ◽  
Biological Activities ◽  
Structural Complexity ◽  
Scale Production ◽  
Natural Product Chemistry ◽  
Product Chemistry

Nature has long served as a rich source of structurally diverse small organic molecules with medicinally relevant biological activities. Despite the historical success of these so-called natural products, the enthusiasm of big pharma to explore these compounds as leads in drug design has waxed and waned. A major contributor to this is their often inherent structural complexity. Such compounds are difficult (often impossible) to access synthetically, a hurdle that can stifle lead development and hinder sustainable large-scale production of promising leads for clinical evaluation. However, in recent years, an emerging synergy between synthetic biology and natural product chemistry offers the potential for a renaissance in our ability to access natural products for drug discovery and development. Advances in genome sequencing, bioinformatics and the maturing of heterologous expression platforms are increasing, enabling the study, and ultimately, the manipulation of plant biosynthetic pathways. The triterpenes are one of the most structurally diverse families of natural products and arguably one of the most underrepresented in the clinic. The plant kingdom is the richest source of triterpene diversity, with >20,000 triterpenes reported so far. Transient expression of genes for candidate enzymes and pathways in amenable plant species is emerging as a powerful and rapid means of investigating and harnessing the plant enzymes involved in generating this diversity. Such platforms also have the potential to serve as production systems in their own right, with the possibility of upscaling these discoveries into commercially useful products using the same overall basic procedure. Ultimately, the carbon source for generation of high-value compounds in plants is photosynthesis. Therefore, we could, with the help of plants, be producing new medicines out of sunlight and ‘thin air’ in green factories in the not too distant future.

Revised Section F: Natural products and related compounds

1999 ◽  
Vol 71 (4) ◽  
pp. 587-643 ◽  
Author(s):  
P. M. Giles
Keyword(s):  
Organic Chemistry ◽  
Natural Products ◽  
Natural Product ◽  
Natural Product Chemistry ◽  
Structural Relationships ◽  
The Creation ◽  
Related Compounds ◽  
Single Set ◽  
Product Chemistry

The nomenclature of natural products has suffered from much confusion, mostly for historical reasons. The isolation of a new substance, in the early days of the science, generally preceded its characterization by a lengthy period. Thus, these compounds were often assigned trivial names that gave no indication of the structure of the molecule and were often found afterwards to be misleading. Even when the original names were later revised (for example: glycerin to glycerol) the new names often expressed the structure imperfectly and were thus unsuitable for the nomenclatural manipulation that is required to name derivatives or stereoisomers. The result was a proliferation of trivial names that taxed the memory of chemists and obscured important structural relationships.The resultant disorder in the literature led to the creation of committees of specialists with the task of codifying the naming of compounds in various connected areas of natural-product chemistry, such as steroids, lipids, and carbohydrates. As far as their recommendations have been followed, their efforts have been successful in eliminating confusing or duplicate nomenclature.It is the aim of the lUPAC Commission on Nomenclature of Organic Chemistry to unite as far as possible all the specialist reports into a single set of recommendations that can be applied in most areas of natural-product chemistry. Accordingly, provisional recommendations were prepared and published as Section F of the lUPAC Organic Nomenclature Rules, first in 1976, and then in the 1979 edition of the Rules.

scholarly journals Fermentation Strategies for Production of Pharmaceutical Terpenoids in Engineered Yeast

2021 ◽  
Vol 14 (4) ◽  
pp. 295
Author(s):  
Erdem Carsanba ◽  
Manuela Pintado ◽  
Carla Oliveira
Keyword(s):  
Natural Products ◽  
High Titer ◽  
Cell Factory ◽  
Special Focus ◽  
Terpene Biosynthesis ◽  
Yeast Saccharomyces Cerevisiae ◽  
Factors Affecting ◽  
Strain Design ◽  
Engineered Yeast ◽  
Market Factors

Terpenoids, also known as isoprenoids, are a broad and diverse class of plant natural products with significant industrial and pharmaceutical importance. Many of these natural products have antitumor, anti-inflammatory, antibacterial, antiviral, and antimalarial effects, support transdermal absorption, prevent and treat cardiovascular diseases, and have hypoglycemic activities. Production of these compounds are generally carried out through extraction from their natural sources or chemical synthesis. However, these processes are generally unsustainable, produce low yield, and result in wasting of substantial resources, most of them limited. Microbial production of terpenoids provides a sustainable and environment-friendly alternative. In recent years, the yeast Saccharomyces cerevisiae has become a suitable cell factory for industrial terpenoid biosynthesis due to developments in omics studies (genomics, transcriptomics, metabolomics, proteomics), and mathematical modeling. Besides that, fermentation development has a significant importance on achieving high titer, yield, and productivity (TYP) of these compounds. Up to now, there have been many studies and reviews reporting metabolic strategies for terpene biosynthesis. However, fermentation strategies have not been yet comprehensively discussed in the literature. This review summarizes recent studies of recombinant production of pharmaceutically important terpenoids by engineered yeast, S. cerevisiae, with special focus on fermentation strategies to increase TYP in order to meet industrial demands to feed the pharmaceutical market. Factors affecting recombinant terpenoids production are reviewed (strain design and fermentation parameters) and types of fermentation process (batch, fed-batch, and continuous) are discussed.

scholarly journals РАЗРАБОТКА ЭЛЕМЕНТОВ МОДЕЛИ УПРАВЛЕНИЯ ПРОЕКТОМ СОЗДАНИЯ ПЛАЗМОХИМИЧЕСКИХ УСТРОЙСТВ ДЛЯ ЭНЕРГЕТИЧЕСКИХ УСТАНОВОК

2018 ◽  
pp. 75-79
Author(s):  
Екатерина Сергеевна Бурунсуз
Keyword(s):  
Project Management ◽  
Process Model ◽  
Power Plants ◽  
Production Systems ◽  
Chemical Elements ◽  
Risk Indicators ◽  
Plasma Chemical ◽  
International Projects ◽  
The Creation ◽  
Initiation Stage

The basic elements of the project management model for the creation of plasma-chemical elements for power plants have been developed. It is shown that the main features of science-intensive projects for the development of energy systems using plasma-chemical elements are: significant complexity of organizational production systems; significant uncertainty of project states and a high probability of risks arising from the influence of factors that cannot be envisaged in the management process; the uniqueness and high cost of the industrial and intellectual resources involved, as well as the problems of cooperation in the context of International projects. A process model for forming the Statute of the project for creation of plasma-chemical devices for power plants was developed to establish information relationships between control processes of one and the different levels, performance indicators, control over their implementation, as well as visualization of processes in the form of detailed subprocesses. The identification of the main risks of project management for the creation of plasma-chemical elements for environmentally friendly power plants in accordance with the life cycle phases has been identified. The risk indicators of projects at macro level, market and project levels have been developed; interconnections and hierarchies between different factors have been established. In order to substantiate the selection of the most significant criteria, a hierarchy analysis method was used, which determined the importance of the criteria for the project team for the creation of a plasma-chemical elements. It has been determined that the own vectors of the criteria are: strategic 39.1%, financial and economic 31%, environmental 16.3%, functional and technological 10.1%, others 3.6%. The developed model takes into account the specific conditions of operation of plasma installations and enables to determine the local and global probabilities of their occurrence at the initiation stage of the project, and also to develop arrangements to minimize their impact on the indicators of the project effectiveness

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