scholarly journals Breast Cancer Translational Research Center of Excellence FY12-14

2014 ◽  
Author(s):  
Craig D. Shriver ◽  
Lee Bronfman
Keyword(s):  
Breast Cancer ◽  
Translational Research ◽  
Research Center ◽  
Center Of Excellence

The Impact of Translational Research in Breast Cancer Care: Can we Improve the Therapeutic Scenario?

2018 ◽  
Vol 18 (6) ◽  
pp. 832-836
Author(s):  
Giuseppe Buono ◽  
Francesco Schettini ◽  
Francesco Perri ◽  
Grazia Arpino ◽  
Roberto Bianco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Translational Research ◽  
Cell Biology ◽  
Cancer Biology ◽  
Hormone Receptors ◽  
Treatment Strategies ◽  
Growth Factor Receptor ◽  
Molecular Heterogeneity ◽  
Therapeutic Implications ◽  
The Impact

Traditionally, breast cancer (BC) is divided into different subtypes defined by immunohistochemistry (IHC) according to the expression of hormone receptors and overexpression/amplification of human epidermal growth factor receptor 2 (HER2), with crucial therapeutic implications. In the last few years, the definition of different BC molecular subgroups within the IHC-defined subtypes and the identification of the important role that molecular heterogeneity can play in tumor progression and treatment resistance have inspired the search for personalized therapeutic approaches. In this scenario, translational research represents a key strategy to apply knowledge from cancer biology to the clinical setting, through the study of all the tumors “omics”, including genomics, transcriptomics, proteomics, epigenomics, and metabolomics. Importantly, the introduction of new high-throughput technologies, such as next generation sequencing (NGS) for the study of cancer genome and transcriptome, greatly amplifies the potential and the applications of translational research in the oncology field. Moreover, the introduction of new experimental approaches, such as liquid biopsy, as well as new-concept clinical trials, such as biomarker-driven adaptive studies, may represent a turning point for BC translational research. </P><P> It is likely that translational research will have in the near future a significant impact on BC care, especially by giving us the possibility to dissect the complexity of tumor cell biology and develop new personalized treatment strategies.

Conference Scene: Advances in breast cancer translational research

2012 ◽  
Vol 1 (3) ◽  
pp. 197-199
Author(s):  
Hatem A Azim ◽  
Fabrice Andre ◽  
Sherene Loi
Keyword(s):  
Breast Cancer ◽  
Translational Research

scholarly journals Fitting Cure Rate Model to Breast Cancer Data of Cancer Research Center

2015 ◽  
Vol 16 (17) ◽  
pp. 7923-7927 ◽  
Author(s):  
Ahmad Reza Baghestani ◽  
Farid Zayeri ◽  
Mohammad Esmaeil Akbari ◽  
Leyla Shojaee ◽  
Naghmeh Khadembashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Research Center ◽  
Rate Model ◽  
Breast Cancer Data ◽  
Cure Rate ◽  
Cancer Data ◽  
Cure Rate Model
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