Noninvasive Detection and Differentiation of Axonal Injury/Loss, Demyelination, and Inflammation

2014 ◽  
Author(s):  
Sheng-Kwei Song ◽  
William M. Spees ◽  
Peng Sun ◽  
Yong Wang ◽  
Anne Cross
Keyword(s):  
Axonal Injury ◽  
Noninvasive Detection

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Traumatic or diffuse axonal injury? Author's response

2000 ◽  
Vol 26 (5) ◽  
pp. 491-491 ◽  
Author(s):  
J. F. Geddes ◽  
H. L. Whitwell ◽  
D. I. Graham
Keyword(s):  
Axonal Injury ◽  
Diffuse Axonal Injury

Radiological and cognitive characteristics of traumatic diffuse axonal injury

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
R. Scheid ◽  
J.P. Schneider ◽  
D. Ott ◽  
K. Walther ◽  
T. Guthke ◽  
...  
Keyword(s):  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Cognitive Characteristics

MRI of the diffuse axonal injury

1992 ◽  
Vol 28 (1) ◽  
pp. 61
Author(s):  
Yang Gu Joo ◽  
Young Hoon Woo ◽  
Soo Jhi Suh
Keyword(s):  
Axonal Injury ◽  
Diffuse Axonal Injury
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