Characterizing and Targeting Replication Stress Response Defects in Breast Cancer

2014 ◽  
Author(s):  
Shiaw-Yih Lin ◽  
Chun-Jen Lin ◽  
Lili Gong ◽  
Hui Dai ◽  
Ju-Seog Lee
Keyword(s):  
Breast Cancer ◽  
Stress Response ◽  
Replication Stress

Characterizing and Targeting Replication Stress Response Defects in Breast Cancer

2012 ◽  
Author(s):  
Shiaw-Yih Lin ◽  
Chun-Jen Lin ◽  
Edward Wang ◽  
Hui Dai ◽  
Ju-Seog Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stress Response ◽  
Replication Stress

scholarly journals CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer

2021 ◽  
Vol 22 (11) ◽  
pp. 5782
Author(s):  
Ashwini Makhale ◽  
Devathri Nanayakkara ◽  
Prahlad Raninga ◽  
Kum Kum Khanna ◽  
Murugan Kalimutho
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Triple Negative Breast Cancer ◽  
Combination Treatment ◽  
Triple Negative ◽  
Annexin V ◽  
Replication Stress ◽  
Breast Cancer Cell Lines ◽  
Combination Strategy

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking targeted therapy. Here, we evaluated the anti-cancer activity of APR-246, a P53 activator, and CX-5461, a RNA polymerase I inhibitor, in the treatment of TNBC cells. We tested the efficacy of individual and combination therapy of CX-5461 and APR-246 in vitro, using a panel of breast cancer cell lines. Using publicly available breast cancer datasets, we found that components of RNA Pol I are predominately upregulated in basal-like breast cancer, compared to other subtypes, and this upregulation is associated with poor overall and relapse-free survival. Notably, we found that the treatment of breast cancer cells lines with CX-5461 significantly hampered cell proliferation and synergistically enhanced the efficacy of APR-246. The combination treatment significantly induced apoptosis that is associated with cleaved PARP and Caspase 3 along with Annexin V positivity. Likewise, we also found that combination treatment significantly induced DNA damage and replication stress in these cells. Our data provide a novel combination strategy by utilizing APR-246 in combination CX-5461 in killing TNBC cells that can be further developed into more effective therapy in TNBC therapeutic armamentarium.

scholarly journals MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells

2020 ◽  
Author(s):  
Takahiko Murayama ◽  
Yasuto Takeuchi ◽  
Kaoru Yamawaki ◽  
Toyoaki Natsume ◽  
Li Mengjiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Replication ◽  
Replication Stress ◽  
Dna Replication Stress

scholarly journals RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

2016 ◽  
Vol 26 (24) ◽  
pp. 3257-3268 ◽  
Author(s):  
Yuan-Cho Lee ◽  
Qing Zhou ◽  
Junjie Chen ◽  
Jingsong Yuan
Keyword(s):  
Dna Replication ◽  
Stress Response ◽  
Binding Protein ◽  
Replication Stress ◽  
Dna Replication Stress

scholarly journals Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy

2017 ◽  
Vol 4 (6) ◽  
pp. e1360978 ◽  
Author(s):  
Xiaolei Pan ◽  
Naveed Ahmed ◽  
Joyce Kong ◽  
Dong Zhang
Keyword(s):  
Stress Response ◽  
Cancer Therapy ◽  
Replication Stress

Abstract SP084: Replication stress response defects predict responses to ICT in non-hypermutated tumors

2021 ◽  
Author(s):  
D McGrail ◽  
P Pilié ◽  
XHF Zhang ◽  
J Rosen ◽  
L Voorwerk ◽  
...  
Keyword(s):  
Stress Response ◽  
Replication Stress

scholarly journals FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

2017 ◽  
Vol 45 (20) ◽  
pp. 11837-11857 ◽  
Author(s):  
Elizabeth L. Thompson ◽  
Jung E. Yeo ◽  
Eun-A Lee ◽  
Yinan Kan ◽  
Maya Raghunandan ◽  
...  
Keyword(s):  
Stress Response ◽  
Replication Stress ◽  
Independent Functions ◽  
Cellular Replication
Sign in / Sign up

Export Citation Format

Share Document