Opioid Abuse after Traumatic Brain Injury: Evaluation Using Rodent Models

2012 ◽  
Author(s):  
Katherine L. Nicholson
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Opioid Abuse ◽  
Rodent Models

Detection of Mild Traumatic Brain Injury in Rodent Models Using Shear Wave Elastography

2014 ◽  
Vol 33 (10) ◽  
pp. 1763-1771 ◽  
Author(s):  
Zinnia S. Xu ◽  
Anning Yao ◽  
Stephanie S. Chu ◽  
Marla K. Paun ◽  
Abbi M. McClintic ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Shear Wave ◽  
Mild Traumatic Brain Injury ◽  
Shear Wave Elastography ◽  
Rodent Models

scholarly journals Propofol effects in rodent models of traumatic brain injury: a systematic review

2021 ◽  
Vol 15 (6) ◽  
pp. 253-265
Author(s):  
Riyadh Firdaus ◽  
Sandy Theresia ◽  
Ryan Austin ◽  
Rani Tiara
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neuroprotective Effect ◽  
Head Injuries ◽  
Inflammatory Factors ◽  
Lesion Volume ◽  
Rodent Models ◽  
Neuroprotective Effects ◽  
Traumatic Lesion ◽  
Neurotoxic Effects

Abstract Background Traumatic brain injury (TBI) causes high mortality and disability worldwide. Animal models have been developed to explore the complex processes in TBI. Propofol is used to manage head injuries during surgical intervention and mechanical ventilation in patients with TBI. Many studies have investigated the neuroprotective effect of propofol on TBI. However, other studies have shown neurotoxic effects. Objectives To review systematically the literature regarding the neuroprotective and neurotoxic effects of propofol in rodent models of TBI. Methods Data from rodents as models of TBI with propofol as one of the intervention agents, and/or comparing the neuroprotective effects of propofol with the other substances in rodent models of TBI, were obtained from PubMed, EBSCO Host, and ProQuest databases. The PRISMA 2020 statement recommendations were followed and research questions were developed based on PICOS guidelines. Data was extracted from the literature using a standardized Cochrane method. Results We analyzed data from 12 articles on physiological changes of experimental animals before and after trauma, the effects of propofol administration, and the observed neurotoxic effects. The effects of propofol administration were observed in terms of changes in traumatic lesion volume, the release of antioxidants and inflammatory factors, and the neurological function of rodent models of TBI. Conclusion Propofol has neuroprotective and neurotoxic effects via several mechanisms, and various doses have been used in research to determine its effects. The timing of administration, the dose administered, and the duration of administration contribute to determine the effect of propofol in rodent models of TBI. However, the doses that produce neuroprotective and neurotoxic effects are not yet clear and further research is needed to determine them.

scholarly journals Improving the translational potential of rodent models to study the behavioral and pathophysiological effects of repetitive mild traumatic brain injury

2018 ◽  
Vol 120 (1) ◽  
pp. 1-3
Author(s):  
Megan E. Huibregtse
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Outcome Measures ◽  
Mild Traumatic Brain Injury ◽  
Chronic Traumatic Encephalopathy ◽  
Rodent Models ◽  
Head Impacts ◽  
Repetitive Head Impacts ◽  
The Impact

Chronic traumatic encephalopathy (CTE) is thought to be caused by repetitive head impacts. Consequently, there is a need to develop rodent models to better understand the behavioral and pathophysiological changes of repetitive mild traumatic brain injury (rmTBI) and to determine the link between rmTBI and CTE. This Neuro Forum article reviews recent rodent rmTBI models, comparing the impact methods and outcome measures in terms of translational potential.

Precisely controllable traumatic brain injury devices for rodent models

2011 ◽  
Author(s):  
R. Abdul-Wahab ◽  
B. Swietek ◽  
S. Mina ◽  
S. Sampath ◽  
V. Santhakumar ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rodent Models

scholarly journals Novel GLP-1R/GIPR co-agonist “twincretin” is neuroprotective in cell and rodent models of mild traumatic brain injury

2017 ◽  
Vol 288 ◽  
pp. 176-186 ◽  
Author(s):  
Ian A. Tamargo ◽  
Miaad Bader ◽  
Yazhou Li ◽  
Seong-Jin Yu ◽  
Yun Wang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Rodent Models
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