Expression of tNASP in Prostate Cancer: Opportunities for a Novel Diagnostic and Prognostic Biomarker Development

2013 ◽  
Author(s):  
Oleg M. Alekseev
Keyword(s):  
Prostate Cancer ◽  
Prognostic Biomarker

scholarly journals HGK promotes metastatic dissemination in prostate cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sara Garcia-Garcia ◽  
Maria Rodrigo-Faus ◽  
Noelia Fonseca ◽  
Sara Manzano ◽  
Balázs Győrffy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Biomarker ◽  
Skeletal Metastases ◽  
Primary Tumors ◽  
Prostate Tumorigenesis ◽  
Actin Organization ◽  
Multi Stage ◽  
Adhesion Stability ◽  
Therapeutic Alternatives ◽  
Cell Dissemination

AbstractMetastasis is the process of cancer cell dissemination from primary tumors to different organs being the bone the preferred site for metastatic homing of prostate cancer (PCa) cells. Prostate tumorigenesis is a multi-stage process that ultimately tends to advance to become metastatic PCa. Once PCa patients develop skeletal metastases, they eventually succumb to the disease. Therefore, it is imperative to identify essential molecular drivers of this process to develop new therapeutic alternatives for the treatment of this devastating disease. Here, we have identified MAP4K4 as a relevant gene for metastasis in PCa. Our work shows that genetic deletion of MAP4K4 or pharmacological inhibition of its encoded kinase, HGK, inhibits metastatic PCa cells migration and clonogenic properties. Hence, MAP4K4 might promote metastasis and tumor growth. Mechanistically, our results indicate that HGK depleted cells exhibit profound differences in F-actin organization, increasing cell spreading and focal adhesion stability. Additionally, HGK depleted cells fails to respond to TNF-α stimulation and chemoattractant action. Moreover, here we show that HGK upregulation in PCa samples from TCGA and other databases correlates with a poor prognosis of the disease. Hence, we suggest that it could be used as prognostic biomarker to predict the appearance of an aggressive phenotype of PCa tumors and ultimately, the appearance of metastasis. In summary, our results highlight an essential role for HGK in the dissemination of PCa cells and its potential use as prognostic biomarker.

scholarly journals RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Aruz Mesci ◽  
Fabrice Lucien ◽  
Xiaoyong Huang ◽  
Eric H. Wang ◽  
David Shin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Biomarker

scholarly journals Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC)

2020 ◽  
Vol 10 ◽  
Author(s):  
Zhao Chen ◽  
Xin Yan ◽  
Guo-Wei Du ◽  
Kurerban Tuoheti ◽  
Xiao-Jie Bai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Prognostic Biomarker ◽  
Potential Tumor Suppressor

TRIM24 as an independent prognostic biomarker for prostate cancer

2019 ◽  
Vol 37 (9) ◽  
pp. 576.e1-576.e10 ◽  
Author(s):  
Anne Offermann ◽  
Doris Roth ◽  
Marie Christine Hupe ◽  
Silke Hohensteiner ◽  
Finn Becker ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Biomarker

scholarly journals ACTL6A is a novel oncogene and prognostic biomarker for prostate cancer

2019 ◽  
Vol 30 ◽  
pp. vi106 ◽  
Author(s):  
Chih-Pin Chuu ◽  
Ching-Yu Lin ◽  
Shih-Han Huang ◽  
Kelvin K -C Tsai
Keyword(s):  
Prostate Cancer ◽  
Prognostic Biomarker

Abstract 3134: CCN3 is a prognostic biomarker and functional mediator of prostate cancer bone metastasis

2019 ◽  
Author(s):  
Matthew Dankner ◽  
Veronique Ouellet ◽  
Laudine Desreumaux-Communal ◽  
Estelle Schmitt ◽  
Dru Perkins ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Prognostic Biomarker
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