Development of a Dedicated Radiotherapy Unit with Real-Time Image Guidance and Motion Management for Accelerated Partial Breast Irradiation

2012 ◽  
Author(s):  
K. S. Chao
Keyword(s):  
Real Time ◽  
Image Guidance ◽  
Accelerated Partial Breast Irradiation ◽  
Partial Breast Irradiation ◽  
Breast Irradiation ◽  
Motion Management ◽  
Real Time Image ◽  
Time Image

397 Intra-tumor immunotherapy injections utilizing image guidance in interventional radiology: clinical trial experience at a tertiary care cancer center

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A422-A422
Author(s):  
Ravi Murthy ◽  
Rahul Sheth ◽  
Alda Tam ◽  
Sanjay Gupta ◽  
Vivek Subbiah ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Interventional Radiology ◽  
Real Time ◽  
Image Guidance ◽  
Tertiary Care ◽  
Cancer Center ◽  
Imaging Guidance ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image

BackgroundImage guided intra-tumor administration of investigational immunotherapeutic agents represents an expanding field of interest. We present a retrospective review of the safety, feasibility & technical nuances of real-time image guidance for injection & biopsy across a spectrum of extracranial solid malignancies utilizing the discipline of Interventional Radiology.MethodsPatients who were enrolled in image guided intratumoral immunotherapy injection (ITITI) clinical trials over a 6 year period (2013–19) at a single tertiary care cancer center were included in this analysis. Malignancy, location, imaging guidance utilized for ITITI & biopsy for injected (adscopal) & non-injected (abscopal) lesions were determined and categorized. Peri-procedural adverse events were noted.Results262 pts (146 female, 61 yrs median) participating in 29 immunotherapeutic clinical trials (TLR & STING agonists, gene therapy, anti CD-40, viral/bacterial/metabolic oncolytics) met study criteria. Malignancies included melanoma 88, sarcoma 32, colorectal 29, breast 23, lung 17, head & neck 15, ovarian 8, neuroendocrine 7, pancreatic adenocarcinoma 6, 3 each (cholangioCA, endometrial, bladder, GI tract), 2 each (RCC, thymicCA, lymphoma, merkel cell, prostate) & others 1 each (CUP, GIST, dermatofibrosarcoma, DSRT, neuroblastoma, thyroid). All 169 & 93 patients received the intended 1371 ITITI in parietal (abdominal/chest wall, extremity, neck, pelvis) or visceral (liver, lung, peritoneum, adrenal) locations respectively; 83 patients received lymph node injections within either location. Imaging guidance was US in 68% of the cohort (US 161, CT+US 19); CT was used in 30% (81) & MRI in 1 patient. Median diameter of the ITITI lesion was 32 mm (8–230 mm). Median volume of the ITITI therapeutic material/session was 2 ml (1–6.9 ml). Lesions were accessed using a coaxial technique. ITITI delivery needles used at operator preference & tailored to lesion characteristics were either a 21G/22G Chiba, 21G Profusion (Cook Medical), 22G Morrison (AprioMed), 25G hypodermic (BD) & 18G Quadrafuse (Rex Medical). 2840 core biopsies (>18G Tru-cut core, Mission, Bard Medical) were performed in 237 patients during 690 procedures; biopsy sessions were often concurrent & of the ITITI site. 137 patients also underwent biopsy of a non-ITITI site (89 parietal location). Dimensions of the non-ITITI lesion were median 10 mm (7–113 mm); US image guidance was used in 97 patients (72%) to obtain a total of 1257, >18G Tru-core samples. 1.3% of injections resulted in SAE (NCI CTC AE >3) and 0.5% of 4097 biopsies developed major complications (SIR Criteria); both categories were manageable.ConclusionsUtilizing real time image guidance, ITITI to the administration of a myriad of investigational immunotherapeutic agents with concomitant biopsy procedures to date are associated with a high technical success rate & favorable safety profile.AcknowledgementsJoshua Hein, Mara Castaneda, Jyotsna Pera, Yunfang Jiang,Shuang Liu, Holly Liu and Anna LuiTrial RegistrationN/AEthics ApprovalThe study was approved by Institution’s Ethics Board, approval number 2020-0536: A retrospective study to determine the safety, feasibility and technical challenges of real-time image guidance for intra-tumor injection and biopsy across multiple solid tumors.Consent2020-0536 Waiver of Informed ConsentReferenceSheth RA, Murthy R, Hong DS, et al. Assessment of image-guided intratumoral delivery of immunotherapeutics in patients with cancer. JAMA Netw Open 2020;3(7):e207911. doi:10.1001/jamanetworkopen.2020.7911

scholarly journals Benefits of Real-Time Image Guidance in Dose-Escalated Pancreatic SBRT

2017 ◽  
Vol 99 (2) ◽  
pp. E158-E159
Author(s):  
B.L. Jones ◽  
W. Campbell ◽  
K.A. Goodman ◽  
Y. Vinogradskiy ◽  
T. Schefter ◽  
...  
Keyword(s):  
Real Time ◽  
Image Guidance ◽  
Real Time Image ◽  
Time Image

scholarly journals Real-Time Image Stabilization Method Based on Optical Flow and Binary Point Feature Matching

Electronics ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 198 ◽  
Author(s):  
Zilong Deng ◽  
Dongxiao Yang ◽  
Xiaohu Zhang ◽  
Yuguang Dong ◽  
Chengbo Liu ◽  
...  
Keyword(s):  
Optical Flow ◽  
Real Time ◽  
Image Matching ◽  
Image Guidance ◽  
Feature Matching ◽  
Guidance System ◽  
Stabilization Method ◽  
Image Stabilization ◽  
Real Time Image ◽  
Time Image

The strap-down missile-borne image guidance system can be easily affected by the unwanted jitters of the motion of the camera, and the subsequent recognition and tracking functions are also influenced, thus severely affecting the navigation accuracy of the image guidance system. So, a real-time image stabilization technology is needed to help improve the image quality of the image guidance system. To satisfy the real-time and accuracy requirements of image stabilization in the strap-down missile-borne image guidance system, an image stabilization method based on optical flow and image matching with binary feature descriptors is proposed. The global motion of consecutive frames is estimated by the pyramid Lucas-Kanade (LK) optical flow algorithm, and the interval frames image matching based on fast retina keypoint (FREAK) algorithm is used to reduce the cumulative trajectory error. A Kalman filter is designed to smooth the trajectory, which is conducive to fitting to the main motion of the guidance system. Simulations have been carried out, and the results show that the proposed algorithm improves the accuracy and real-time performance simultaneously compared to the state-of-art algorithms.

P186: Real-Time Image Guidance in Endoscopic Sinus Ssurgery

2007 ◽  
Vol 137 (2_suppl) ◽  
pp. P272-P273
Author(s):  
Mikio Suzuki ◽  
Hironori Sakurai
Keyword(s):  
Real Time ◽  
Image Guidance ◽  
Real Time Image ◽  
Time Image

The effect of augmented real-time image guidance on task workload during endoscopic sinus surgery

2012 ◽  
Vol 2 (5) ◽  
pp. 405-410 ◽  
Author(s):  
Benjamin J. Dixon ◽  
Harley Chan ◽  
Michael J. Daly ◽  
Allan D. Vescan ◽  
Ian J. Witterick ◽  
...  
Keyword(s):  
Real Time ◽  
Endoscopic Sinus Surgery ◽  
Image Guidance ◽  
Sinus Surgery ◽  
Real Time Image ◽  
Time Image

Contrast-Enhanced Ultrasound in Hepatobiliary Interventions

2019 ◽  
Vol 03 (03) ◽  
pp. 240-242
Author(s):  
Johannes Rübenthaler ◽  
Vincent Schwarze ◽  
Constantin Marschner ◽  
Giovanna Negrão de Figueiredo ◽  
Dirk-André Clevert
Keyword(s):  
Real Time ◽  
Image Guidance ◽  
Treatment Success ◽  
Interventional Treatment ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Real Time Image ◽  
Magnetic Resonance Imaging Mri ◽  
Malignant Liver ◽  
Time Image

AbstractContrast-enhanced ultrasound (CEUS) has been widely accepted as a diagnostic tool for the detection and evaluation of benign and malignant liver lesions and has been implemented into the clinical routine as a tool for percutaneous interventional real-time image guidance. CEUS can be combined with computed tomography (CT) and magnetic resonance imaging (MRI) datasets using real-time image fusion to additionally surveil proper interventional treatment and assess treatment success. This review describes the state-of-the-art use of CEUS for the surveillance and monitoring of interventional procedures of the liver and for the evaluation of postinterventional success.

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