Epigenetic Alterations Associated With CCCTC-Binding Factor Deregulation in Prostate Cancer

2013 ◽  
Author(s):  
Jin-Hee Lee
Keyword(s):  
Prostate Cancer ◽  
Epigenetic Alterations ◽  
Binding Factor

scholarly journals BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence

2014 ◽  
Vol 47 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Lei Gu ◽  
◽  
Sandra C Frommel ◽  
Christopher C Oakes ◽  
Ronald Simon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Disease Recurrence ◽  
Epigenetic Alterations

S74 STUDY OF GENETIC AND EPIGENETIC ALTERATIONS IN URINE SAMPLES AS DIAGNOSTIC MARKERS FOR PROSTATE CANCER

2010 ◽  
Vol 9 (6) ◽  
pp. 576
Author(s):  
T. Kalogeropoulos ◽  
E. Dimitriadis ◽  
V. Klapsas ◽  
S. Sotiriou ◽  
E. Koutsiaris ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diagnostic Markers ◽  
Urine Samples ◽  
Epigenetic Alterations

510 QUANTIFICATION OF EPIGENETIC ALTERATIONS IN PROSTATE CANCER

2011 ◽  
Vol 10 (2) ◽  
pp. 171
Author(s):  
T.C. Stadler ◽  
A. Jung ◽  
B. Schlenker ◽  
A.L. Boulesteix ◽  
C. Bernau ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Epigenetic Alterations

scholarly journals Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Xuanrong Chen ◽  
Qianwang Ma ◽  
Zhiqun Shang ◽  
Yuanjie Niu
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Regulatory Element ◽  
Basic Research ◽  
Epigenetic Alterations ◽  
Transcriptional Dysregulation ◽  
Super Enhancer ◽  
Cancer Phenotype ◽  
Key Drivers ◽  
Large Clusters

AbstractAbnormal activity of oncogenic and tumor-suppressor signaling pathways contributes to cancer and cancer risk in humans. Transcriptional dysregulation of these pathways is commonly associated with tumorigenesis and the development of cancer. Genetic and epigenetic alterations may mediate dysregulated transcriptional activity. One of the most important epigenetic alternations is the non-coding regulatory element, which includes both enhancers and super-enhancers (SEs). SEs, characterized as large clusters of enhancers with aberrant high levels of transcription factor binding, have been considered as key drivers of gene expression in controlling and maintaining cancer cell identity. In cancer cells, oncogenes acquire SEs and the cancer phenotype relies on these abnormal transcription programs driven by SEs, which leads to cancer cells often becoming addicted to the SEs-related transcription programs, including prostate cancer. Here, we summarize recent findings of SEs and SEs-related gene regulation in prostate cancer and review the potential pharmacological inhibitors in basic research and clinical trials.

675 COMPARATIVE ANALYSIS OF EPIGENETIC ALTERATIONS ON CHROMOSOME 13Q14 IN PROSTATE CANCER

2007 ◽  
Vol 6 (2) ◽  
pp. 191
Author(s):  
M. Hering ◽  
U. Schmidt ◽  
S. Füssel ◽  
A. Lohse ◽  
K. Robel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Comparative Analysis ◽  
Epigenetic Alterations ◽  
Chromosome 13Q14
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