Therapeutic Role of Bmi-1 Inhibitors in Eliminating Prostate Tumor Stem Cells

2013 ◽  
Author(s):  
Isaac Y. Kim ◽  
Joseph Bertino ◽  
Hatem E. Sabaawy
Keyword(s):  
Stem Cells ◽  
Prostate Tumor ◽  
Tumor Stem Cells ◽  
Therapeutic Role

scholarly journals TMIC-56. ROLE OF HUMAN BRAIN TUMOR STEM CELLS-DERIVED EXTRACELLULAR VESICLES ON THE PHENOTYPIC TRANSDIFFERENTIATION OF HUMAN NEURAL PROGENITOR CELLS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi260-vi260
Author(s):  
Natanael Zarco ◽  
Emily Norton ◽  
Montserrat Lara-Velazquez ◽  
Anna Carrano ◽  
Alfredo Quinones-Hinojosa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Tumor Microenvironment ◽  
Extracellular Vesicles ◽  
Primary Cultures ◽  
Adult Brain ◽  
Cell Subpopulation ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

Abstract Glioblastoma (GBM) is the most aggressive of all the brain tumors with a median patient survival less than 15 months. Despite of surgical resection, radiotherapy, and chemotherapy, recurrence rate is almost 100%. A great percentage of GBM tumors (~60%) infiltrate and contact the ventricular-subventricular zone (V-SVZ). Interestingly, these tumors are the most aggressive, and invariably lead to higher distal recurrence rates, shorter time to tumor progression, and lower overall survival of the patient. The reason for this role of V-SVZ-proximity on the outcome of GBM patients is unknown. We suggest that a potential explanation is the interaction of GBM with the V-SVZ. This region is the largest neurogenic niche in the adult brain where neural stem cells (NSCs) give rise to newborn neuroblasts that migrate toward the olfactory bulb. In GBM there is a cell subpopulation called brain tumor stem cells (BTSCs) with NSCs-like characteristics, but with added potential for tumor initiation, recurrence and invasiveness. Tumor microenvironment plays an important role in migration and invasion process. In the present work, we used the total exosome isolation kit to purify Extracellular Vesicles (EVs) from human primary cultures of BTSCs. We determined that BTSCs-derived EVs contain specific information that is transfer to primary cultures of human Neural Progenitors Cells (NPCs) modulating their proliferation rate, cell viability, and migration. In addition, we identify that NPCs taken up BTSCs-derived EVs and significantly increase the expression levels of stemness-related genes such as Nestin, Nanog, and Sox2, suggesting that a phenotypic transdifferentiation is being carry out. These results support our hypothesis that GBM modulate the tumor microenvironment close to the V-SVZ by releasing EVs that target cellular components in this region and promote their phenotypic transformation, highlighting that NPCs biology changes in the context of tumor environment.

Melatonin improves the therapeutic role of mesenchymal stem cells in diabetic rats

2018 ◽  
Vol 28 (7) ◽  
pp. 529-538 ◽  
Author(s):  
Shadia M. Kadry ◽  
Mai H. El-Dakdoky ◽  
Nawal Z. Haggag ◽  
Laila A. Rashed ◽  
Marwa T. Hassen
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Diabetic Rats ◽  
Therapeutic Role

scholarly journals Examination of the Therapeutic Potential of Delta-24-RGD in Brain Tumor Stem Cells: Role of Autophagic Cell Death

2007 ◽  
Vol 99 (18) ◽  
pp. 1410-1414 ◽  
Author(s):  
Hong Jiang ◽  
Candelaria Gomez-Manzano ◽  
Hiroshi Aoki ◽  
Marta M.. Alonso ◽  
Seiji Kondo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Brain Tumor ◽  
Therapeutic Potential ◽  
Autophagic Cell Death ◽  
Tumor Stem Cells ◽  
Brain Tumor Stem Cells

scholarly journals Nanocurcumin Improves the Therapeutic Role of Mesenchymal Stem Cells in Liver Fibrosis Rats

2021 ◽  
Vol 11 (6) ◽  
pp. 14463-14479
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Fibrosis ◽  
Therapeutic Agent ◽  
Albino Rats ◽  
Therapeutic Role ◽  
Recovery Group ◽  
Wistar Albino Rats ◽  
Promising Therapeutic Agent

Nano-curcumin (Nano-Cur) is a promising therapeutic agent that has a wide array of effective medicinal potentials. Therefore, the present inquiry aimed to assess Nano-Cur's impact on the therapeutic effect of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in the rat model of liver fibrosis prompted by carbon tetrachloride (CCl4). Liver fibrosis was developed in 30male Wistar albino rats which were divided into five groups, six animals each. The 1st group (CCl4 group) was sacrificed immediately after the induction of liver fibrosis. The 2nd group received a single iv injection of BM-MSCs and left for 4weeks, the3rd group received 100mg/kg b.w. Nano-Cur 3times/week for 4weeks, the 4th group received a single iv injection of 107 BM-MSCs accompanied with Nano-Cur 3times/week for 4weeks, and the 5th group left for 4weeks without any intervention. Data revealed that treatment with BM-MSCs plus Nano-Cur alleviated liver fibrosis through reducing liver oxidative stress and restoring both liver histological picture and enzymatic profile. Additionally, companied treatment resulted in reducing TGFβ1 levels and attenuating the expression of Smad 2,3 and collagen I, III genes. Conversely, most of the pathological lesions were still detected in the recovery group. Nano-Cur improves the therapeutic role of BM-MSCs in liver fibrosis rats.

THE ROLE OF VASCULAR MICROENVIRONMENT IN THE FORMATION AND DEVELOPMENT OF BRAIN TUMORS

2018 ◽  
Vol 64 (5) ◽  
pp. 570-577
Author(s):  
Aleksandr Dorosevich ◽  
N. Buzgan
Keyword(s):  
Stem Cells ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Cell Lines ◽  
Crucial Role ◽  
Tumor Stem Cells ◽  
Intercellular Interactions ◽  
Resident Cell ◽  
The Brain

Processes of neovascularization are key for the growth and spread of tumor cells. This article describes unique patterns of angiogenesis, which are considered as specific exclusively for brain tumors. At present the role of specialized perivascular niches in the development of oncological processes of the brain acquires a growing importance in the eyes of researchers. Perivascular niches play a crucial role in intercellular interactions between resident cell lines in the development of the tumor process and are also a source of tumor stem cells.

Understanding the role of tumor stem cells in glioblastoma multiforme: a review article

2010 ◽  
Vol 103 (3) ◽  
pp. 397-408 ◽  
Author(s):  
Aalya Fatoo ◽  
Michael J. Nanaszko ◽  
Baxter B. Allen ◽  
Christina L. Mok ◽  
Elena N. Bukanova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioblastoma Multiforme ◽  
Review Article ◽  
Tumor Stem Cells

The possible therapeutic role of mesenchymal stem cells in amiodarone-induced lung injury in adult male albino rats

2018 ◽  
Vol 46 (3) ◽  
pp. 172
Author(s):  
MaramM.M Ghabrial ◽  
MaysaF.M Salem ◽  
AmlM.A.A El Ela ◽  
SafwatA.A El Deeb
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Adult Male ◽  
Albino Rats ◽  
Therapeutic Role

THE ROLE OF TUMOR STEM CELLS IN THE DEVELOPMENT OF CEREBRAL GLIOMAS

2015 ◽  
pp. 5-14 ◽  
Author(s):  
V. A. Byvaltsev ◽  
◽  
I. A. Stepanov ◽  
E. G. Belykh ◽  
A. I. Yarullina ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Stem Cells ◽  
Cerebral Gliomas
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