Improving the Diagnostic Specificity of CT for Early Detection of Lung Cancer: 4D CT-Based Pulmonary Nodule Elastometry

2013 ◽  
Author(s):  
Jr Loo ◽  
Maxim Billy W. ◽  
Peter G.
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Pulmonary Nodule ◽  
Diagnostic Specificity ◽  
4D Ct

scholarly journals Clinical Utility of Circulating Tumor Cells in the Early Detection of Lung Cancer in Patients with a Solitary Pulmonary Nodule

2021 ◽  
Vol 20 ◽  
pp. 153303382110414
Author(s):  
Manhua Zhong ◽  
Yi Zhang ◽  
Zuguang Pan ◽  
Wei Wang ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Neuron Specific Enolase ◽  
Serum Levels ◽  
Lavage Fluid ◽  
Cancer Antigen 125

Objective: Lung cancer is the most common cancer and can appear as a solitary pulmonary nodule. Early detection of lung cancer in this patient population would be beneficial for the disease management. In this study, the potential application of circulating tumor cells (CTCs) on early detection of lung cancer in this population was investigated. Methods: The number of CTCs in bronchoalveolar lavage fluid and serum levels of tumor-related markers, cancer antigen 125 (CA125), carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) were measured in patients with a solitary pulmonary nodule. The association between CTCs and lung cancer was examined. The diagnosis performances of CTCs and selected tumor-related markers were compared. Results: The CTC positivity was significantly associated with lung cancer ( P = .009). The sensitivity of CTCs and CA125, CEA, NSE, and CA125/CEA/NSE was 75%, 5.6%, 0%, 25%, and 33%, respectively. The sensitivity of CTCs was improved from 75% to 83% by the combination with CA125 or NSE. Conclusion: CTCs may be helpful for the early detection of lung cancer in patients with a solitary pulmonary nodule.

Application “Lung Nodule" Software With Lungrads On Early Detection And Follow Up The Pulmonary Nodules By Lung Low Dose CT Findings

2020 ◽  
Author(s):  
Ha Hoang Thi Ngoc
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Pulmonary Nodule ◽  
Low Dose ◽  
False Negative ◽  
Lung Nodule ◽  
Pulmonary Nodules ◽  
Lung Cancer Mortality ◽  
Smoking History ◽  
Low Dose Ct

Background: A pulmonary nodule is defined as a rounded or irregular opacity, well or poorly defined, measuring up to 3 cm in diameter. Early detection the malignancy of nodules has a significant role in decreasing the mortality, increasing the survival time and consider as early diagnosis lung cancer. Content: The main risk factors are those of current or former smokers, aged 55 to 74 years with a smoking history of at least 1 pack-day. Low dose CT: Screening individuals with high risk of lung cancer by low dose CT scans could reduce lung cancer mortality by 20 percent compared to chest X-ray. Radiation dose has to maximum reduced but respect the rule of ALARA (As Low as Resonably Archivable). ACR-LungRADS 2014: Classification of American College of Radiology, LungRADS, is a newly application but showed many advantages in comparison with others classification such as increasing positive predict value (PPV), no result of false negative and cost effectiveness. “Lung nodule” was applied as a smart phone application in order to have a quickly evaluation, especially the malignancy and management face on a pulmonary nodule.

Study the value of lung low dose computed tomography in early detection the malignant pulmonary nodule

2020 ◽  
pp. 7-15
Author(s):  
Ha Hoang ◽  
Tien Doan Dung ◽  
Khoan Le Trong
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Early Detection ◽  
Pulmonary Nodule ◽  
Pulmonary Nodules ◽  
Diagnostic Value ◽  
Cross Sectional Study ◽  
Solitary Pulmonary Nodules ◽  
Cross Sectional ◽  
The Right

Background: Early diagnosis of the malignant pulmonary nodules plays an important role in decreasing the mortality, increasing the lifetime and considering as early detection of lung cancer. Objectives: To describe the characteristics and diagnostic value of the malignant suspected signs of pulmonary nodule. Materials and methods: A descriptive cross-sectional study on 33 patients with localized pulmonary nodule which has indications of biopsy or surgery at Hospital of Hue University of Medicine and Pharmacy from 05/2017 to 08/2018. Results: A majority of pulmonary nodules were found in the right upper lobe with 42.4%; solitary pulmonary nodules made up the majority of 75.8%. (Nodules > 21.5 mm: 57.6%; nodules ≤ 21.5 mm: 42.4%; solid nodules: 97% and mixed nodules: 3%, round shape: 42.4% and polygons: 57.6%; irregular margin: 78.8%; regular margin: 21.2%; eccentric and stippled calcification: 18.2%; non-calcification: 81.8%; air-bronchogram in nodules: 39.4%; air-bronchogram (-): 60.6%; fat containing pulmonary nodules: 6.1%, malignant and benign confirmed by biopsy: 39.3% and 60.7% respectively. The sensitivity and specificity of features included size > 21.5 mm; air-bronchogram in nodules, polygons for malignant nodules diagnosis are 81.6%; 92.3%; 76.9% and 60%, 65%, 85% respectively. Conclusions: Three features of nodules: Size ≥ 21.5 mm; air-bronchogram and polygons are suggestive malignant characteristics. The combination of two or more characteristics have the sensitive 92.3% and specific 80% Keywords: pulmonary nodule, thoracic computed tomography, lung cancer.

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