90-Day Inhalation Toxicity Study of Hydroprocessed Esters and Fatty Acids (HEFA) Bio-Based Jet Fuel in Rats (Rattus norvegicus) with Neurotoxicity Testing and Genotoxicity Assay

2013 ◽  
Author(s):  
Brian A. Wong ◽  
William R. Howard ◽  
Teresa R. Sterner ◽  
Michelle W. Elliott ◽  
David R. Mattie
Keyword(s):  
Fatty Acids ◽  
Rattus Norvegicus ◽  
Jet Fuel ◽  
Toxicity Study ◽  
Inhalation Toxicity

Acute Inhalation Toxicity Study of 1, 4-Dioxane in Rats (Rattus norvegicus)

2012 ◽  
Author(s):  
David R. Mattie ◽  
Timothy W. Bucher ◽  
Ashton L. Carter ◽  
Deidre E. Stoffregen ◽  
James E. Reboulet ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Toxicity Study ◽  
Inhalation Toxicity

scholarly journals A 90-Day Continuous Vapor Inhalation Toxicity Study of JP-8 Jet Fuel Followed by 20 or 21 Months of Recovery in Fischer 344 Rats and C57BL/6 Mice

1991 ◽  
Vol 19 (2) ◽  
pp. 77-87 ◽  
Author(s):  
David R. Mattie ◽  
Carl L. Alden ◽  
Teresa K. Newell ◽  
Charles L. Gaworski ◽  
Carlyle D. Flemming
Keyword(s):  
Jet Fuel ◽  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Fischer 344 Rats ◽  
Fischer 344

90-Day Inhalation Toxicity Study of FT Fuel

2011 ◽  
Author(s):  
David R. Mattie ◽  
Teresa R. Sterner ◽  
Brian A. Wong ◽  
Darol E. Dodd ◽  
Debra K. Layko ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Inhalation Toxicity

90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats

2021 ◽  
pp. 112780
Author(s):  
Shu-Chieh Hu ◽  
Seonggi Min ◽  
Hyun-Ki Kang ◽  
Dong-Jin Yang ◽  
Mallikarjuna Basavarajappa ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Diethylene Glycol Monomethyl Ether 13-Week Vapor Inhalation Toxicity Study in Rats

1985 ◽  
Vol 5 (6part1) ◽  
pp. 1174-1179
Author(s):  
R. R. MILLER ◽  
D. L. EISENBRANDT ◽  
T. S. GUSHOW ◽  
S. K. WEISS
Keyword(s):  
Diethylene Glycol ◽  
Monomethyl Ether ◽  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Glycol Monomethyl Ether

scholarly journals Aerosols of synthetic amorphous silica do not induce fibrosis in lungs after inhalation: Pathology working group review of histopathological specimens from a subchronic 13-week inhalation toxicity study in rats

2018 ◽  
Vol 2 ◽  
pp. 239784731880527
Author(s):  
Klaus Weber ◽  
Axel Bosch ◽  
Mario Bühler ◽  
Chirukandath Gopinath ◽  
Jerry F Hardisty ◽  
...  
Keyword(s):  
Amorphous Silica ◽  
Working Group ◽  
Recovery Period ◽  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Synthetic Amorphous Silica ◽  
Comparative Group ◽  
Quartz Dust ◽  
High Level ◽  
Dose Levels

In a subchronic (13-week) inhalation toxicity study with a terminal sacrifice (after 13 weeks inhalation) and several recovery period sacrifices (13, 26, 39, and 52 weeks), the effects of AEROSIL® 200 (pyrogenic synthetic amorphous silica (SAS)), AEROSIL® R 974 (surface-treated pyrogenic SAS), and SIPERNAT® 22 S (precipitated SAS) were tested in rats at multiple dose levels. The aforementioned materials are all SAS products. A comparative group of animals was exposed to quartz dust. This study attempts to reexamine the lung tissues originally evaluated in a study published by Reuzel et al. using the current standards. To reach a high level of credibility, the results of the reevaluation were subsequently examined by a pathology working group (PWG). In particular, the reevaluating pathologist and the PWG concluded that, even though quartz (crystalline silica) persisted, induced alterations in the lungs following 13 weeks of exposure to amorphous silicas were reversible following 52 weeks of recovery. A long-term adversity has not been established with SAS products. However, quartz dust damages lungs significantly by causing pulmonary fibrosis.

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