Detection of Xenotropic Murine Leukemia Virus Related Virus (XMRV) in Gulf War Illness: Role in Pathogenesis or Biomarker?

2013 ◽  
Author(s):  
Vincent C. Lombardi
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Gulf War ◽  
Gulf War Illness ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

scholarly journals Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin

2014 ◽  
Vol 47 (3) ◽  
pp. 302-306 ◽  
Author(s):  
Samara Tatielle Monteiro Gomes ◽  
Luciana Imbiriba ◽  
Rommel Rodriguéz Burbano ◽  
Artur Luiz da Costa Silva ◽  
Rosimar Neris Martins Feitosa ◽  
...  
Keyword(s):  
Murine Leukemia Virus ◽  
Amazon Basin ◽  
Leukemia Virus ◽  
Brazilian Amazon ◽  
Human Infection ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

scholarly journals The tale of xenotropic murine leukemia virus-related virus

2012 ◽  
Vol 93 (5) ◽  
pp. 915-924 ◽  
Author(s):  
Harriet C. T. Groom ◽  
Kate N. Bishop
Keyword(s):  
Murine Leukemia Virus ◽  
Prostate Cancer Patient ◽  
Leukemia Virus ◽  
Chronic Fatigue ◽  
Xenotropic Murine Leukemia ◽  
Fatigue Syndrome ◽  
Related Virus ◽  
Potential Association ◽  
The Media ◽  
Murine Leukemia

In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic murine leukemia virus-related virus (XMRV), this was potentially the third class of retrovirus to be pathogenic in humans. XMRV made a more dramatic impact on the wider scientific community, and indeed the media, in 2009 when it was reported to be present in a remarkably high proportion of patients with chronic fatigue syndrome as well as a significant, albeit smaller, proportion of healthy controls. The apparent strong link to disease and the fear of a previously unknown retrovirus circulating in the general population lead to a surge in XMRV research. Subsequent studies failed to find an association of XMRV with disease and, in most cases, failed to find the virus in human samples. In 2011, the case against XMRV and human disease strengthened, ending with several decisive publications revealing the origin of the virus and demonstrating contamination of samples. In this review, we outline the passage of research on XMRV and its potential association with disease from its isolation to the present day, where we find ourselves at the end of a turbulent story.

scholarly journals Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients

Retrovirology ◽  
2009 ◽  
Vol 6 (1) ◽  
pp. 92 ◽  
Author(s):  
Oliver Hohn ◽  
Hans Krause ◽  
Pia Barbarotto ◽  
Lars Niederstadt ◽  
Nadine Beimforde ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

scholarly journals Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity

Virology ◽  
2011 ◽  
Vol 410 (1) ◽  
pp. 234-239 ◽  
Author(s):  
Hal P. Bogerd ◽  
Fengwen Zhang ◽  
Paul D. Bieniasz ◽  
Bryan R. Cullen
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Virus Infectivity ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Apobec3 Proteins ◽  
Murine Leukemia

scholarly journals Androgen Stimulates Transcription and Replication of Xenotropic Murine Leukemia Virus-Related Virus

2009 ◽  
Vol 84 (3) ◽  
pp. 1648-1651 ◽  
Author(s):  
Beihua Dong ◽  
Robert H. Silverman
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Cellular Genes ◽  
Glucocorticoid Response ◽  
Murine Leukemia ◽  
Transcription And Replication

ABSTRACT Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus originally identified in a subset of prostate cancer patients. Because androgens stimulate prostate tumors and some retroviruses, we investigated the effects of dihydrotestosterone (DHT) on XMRV transcription and replication. Transcription from the XMRV U3 region was stimulated up to 2-fold by DHT, but only in cells containing a functional androgen receptor. Mutations in the glucocorticoid response element (GRE) of XMRV impaired basal transcription and androgen responsiveness. Furthermore, DHT stimulated XMRV replication 3-fold, whereas androgen inhibitors (casodex and flutamide) suppressed viral growth up to 3-fold. Findings suggest that integration of the XMRV long terminal repeat (LTR) into host DNA could impart androgen stimulation on cellular genes.

Absence of xenotropic murine leukemia virus-related virus in blood donors in China

Transfusion ◽  
2011 ◽  
Vol 52 (2) ◽  
pp. 326-331 ◽  
Author(s):  
Zhiqiang Mi ◽  
Ying Lu ◽  
Shana Zhang ◽  
Xiaoping An ◽  
Xiaona Wang ◽  
...  
Keyword(s):  
Murine Leukemia Virus ◽  
Blood Donors ◽  
Leukemia Virus ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia
Sign in / Sign up

Export Citation Format

Share Document