Roles of SGK Isoform Signaling in Breast Cancer Migration and Invasion

2013 ◽  
Author(s):  
Jessica Gasser
Keyword(s):  
Breast Cancer ◽  
Migration And Invasion ◽  
Cancer Migration

scholarly journals AMPKα1 Regulates Lung and Breast Cancer Progression by Regulating TLR4-Mediated TRAF6-BECN1 Signaling Axis

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3289
Author(s):  
Mi-Jeong Kim ◽  
Yoon Min ◽  
Juhee Son ◽  
Ji Young Kim ◽  
Ji Su Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
A549 Cells ◽  
Migration And Invasion ◽  
Serum Starvation ◽  
Lung Cancers ◽  
Cancer Migration ◽  
Expression Of Genes ◽  
Autophagy Induction ◽  
Signaling Axis

TRAF6-BECN1 signaling axis is critical for autophagy induction and functionally implicated in cancer progression. Here, we report that AMP-activated protein kinase alpha 1 (AMPKα1, PRKAA1) is positively involved in autophagy induction and cancer progression by regulating TRAF6-BECN1 signaling axis. Mechanistically, AMPKα1 interacted with TRAF6 and BECN1. It also enhanced ubiquitination of BECN1 and autophagy induction. AMPKα1-knockout (AMPKα1KO) HEK293T or AMPKα1-knockdown (AMPKα1KD) THP-1 cells showed impaired autophagy induced by serum starvation or TLR4 (Toll-like receptor 4) stimulation. Additionally, AMPKα1KD THP-1 cells showed decreases of autophagy-related and autophagosome-related genes induced by TLR4. AMPKα1KO A549 cells exhibited attenuation of cancer migration and invasion induced by TLR4. Moreover, primary non-small cell lung cancers (NSCLCs, n = 6) with low AMPKαl levels showed markedly decreased expression of genes related to autophagy, cell migration and adhesion/metastasis, inflammation, and TLRs whereas these genes were significantly upregulated in NSCLCs (n = 5) with high AMPKαl levels. Consistently, attenuation of cancer migration and invasion could be observed in AMPKα1KO MDA-MB-231 and AMPKα1KO MCF-7 human breast cancer cells. These results suggest that AMPKα1 plays a pivotal role in cancer progression by regulating the TRAF6-BECN1 signaling axis for autophagy induction.

Circular RNA circVAPA regulates breast cancer cell migration and invasion via sponging miR-130a-5p

Epigenomics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 303-317 ◽  
Author(s):  
Si-ying Zhou ◽  
Wei Chen ◽  
Su-jin Yang ◽  
Jian Li ◽  
Jun-ying Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Circular Rna ◽  
Migration And Invasion ◽  
Mirna Sponge ◽  
Cell Migration And Invasion ◽  
Cancer Migration ◽  
Cancer Tissues ◽  
The Relationship

Aim: We aimed to explore the roles of circular RNA, circVAPA in regulating cell migration and invasion of breast cancer. Materials & methods: CircVAPA expression was detected in breast cancer tissues and cells. The role of circVAPA was evaluated by MTT assay, wound-healing and transwell assay. The relationship between circVAPA and miR-130a-5p and the location of circVAPA were explored. Results: We discovered that circVAPA was dysregulated in breast cancer tissues and cells. Ectopic circVAPA regulated breast cancer migration, invasion and proliferation. CircVAPA was mainly expressed in the cytoplasm and could act as a miRNA sponge for miR-130a-5p, but did not regulate its parental gene. Conclusion: CircVAPA may promote migration and invasion capacity of breast cancer via harboring miR-130a-5p.

scholarly journals Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4

2009 ◽  
Vol 69 (14) ◽  
pp. 5743-5751 ◽  
Author(s):  
Yan Xie ◽  
Dennis W. Wolff ◽  
Taotao Wei ◽  
Bo Wang ◽  
Caishu Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
G Protein ◽  
Migration And Invasion ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Proteasome Degradation ◽  
Cancer Migration

scholarly journals TGF-β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways

2018 ◽  
Vol 12 (3) ◽  
pp. 305-321 ◽  
Author(s):  
Yuanyuan Zhao ◽  
Jing Ma ◽  
Yanling Fan ◽  
Zhiyong Wang ◽  
Ran Tian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Migration And Invasion ◽  
Cancer Migration

scholarly journals MicroRNA-34c Suppresses Breast Cancer Migration and Invasion by Targeting GIT1

2016 ◽  
Vol 7 (12) ◽  
pp. 1653-1662 ◽  
Author(s):  
Wei-Yang Tao ◽  
Chun-Yang Wang ◽  
Yong-Hui Sun ◽  
Yong-Hui Su ◽  
Da Pang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Migration And Invasion ◽  
Cancer Migration

scholarly journals MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1

2015 ◽  
Vol 35 (3) ◽  
pp. 1425-1432 ◽  
Author(s):  
QIAN JIANG ◽  
MIAO HE ◽  
MENG-TAO MA ◽  
HUI-ZHE WU ◽  
ZHAO-JIN YU ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Migration And Invasion ◽  
Cancer Migration
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