Integrated Device for Circulating Tumor Cell Capture, Characterization and Lens-Free Microscopy

2012 ◽  
Author(s):  
Richard Cote ◽  
Changhuei Yang ◽  
Ram Datar
Keyword(s):  
Tumor Cell ◽  
Circulating Tumor Cell ◽  
Cell Capture ◽  
Integrated Device

Abstract 4070: Development of circulating tumor cell capture from whole blood using beads and microfluidics

2012 ◽  
Author(s):  
Jason G. Kralj ◽  
Chanda Arya ◽  
Thomas P. Forbes ◽  
Matthew S. Munson ◽  
Samuel P. Forry
Keyword(s):  
Tumor Cell ◽  
Whole Blood ◽  
Circulating Tumor Cell ◽  
Cell Capture

scholarly journals Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society

2016 ◽  
Vol 140 (8) ◽  
pp. 825-829 ◽  
Author(s):  
Lynette M. Sholl ◽  
Dara L. Aisner ◽  
Timothy Craig Allen ◽  
Mary Beth Beasley ◽  
Philip T. Cagle ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Liquid Biopsy ◽  
Media Coverage ◽  
Diagnostic Delay ◽  
Genetic Material ◽  
Circulating Tumor Cell ◽  
Lower Sensitivity ◽  
Cell Capture ◽  
Cellsearch System

Liquid biopsy has received extensive media coverage and has been called the holy grail of cancer detection. Attempts at circulating tumor cell and genetic material capture have been progressing for several years, and recent financially and technically feasible improvements of cell capture devices, plasma isolation techniques, and highly sensitive polymerase chain reaction– and sequencing-based methods have advanced the possibility of liquid biopsy of solid tumors. Although practical use of circulating RNA-based testing has been hindered by the need to fractionate blood to enrich for RNAs, the detection of circulating tumor cells has profited from advances in cell capture technology. In fact, the US Food and Drug Administration has approved one circulating tumor cell selection platform, the CellSearch System. Although the use of liquid biopsy in a patient population with a genomically defined solid tumor may potentially be clinically useful, it currently does not supersede conventional pretreatment tissue diagnosis of lung cancer. Liquid biopsy has not been validated for lung cancer diagnosis, and its lower sensitivity could lead to significant diagnostic delay if liquid biopsy were to be used in lieu of tissue biopsy. Ultimately, notwithstanding the enthusiasm encompassing liquid biopsy, its clinical utility remains unproven.

scholarly journals Multivalent Binding and Biomimetic Cell Rolling Improves the Sensitivity and Specificity of Circulating Tumor Cell Capture

2018 ◽  
Vol 24 (11) ◽  
pp. 2539-2547 ◽  
Author(s):  
Ja Hye Myung ◽  
Michael J. Eblan ◽  
Joseph M. Caster ◽  
Sin-Jung Park ◽  
Michael J. Poellmann ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Sensitivity And Specificity ◽  
Circulating Tumor Cell ◽  
Cell Capture ◽  
Cell Rolling ◽  
Multivalent Binding

Circulating tumor cell capture and analysis in a multicenter SWOG-coordinated prostate cancer trial.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. TPS342-TPS342
Author(s):  
A. Goldkorn ◽  
T. Xu ◽  
B. Lu ◽  
A. Williams ◽  
L. M. Fink ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Cell ◽  
Circulating Tumor Cell ◽  
Cell Capture ◽  
Cancer Trial
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