Optimizing Segmental Bone Regeneration Using Functionally Graded Scaffolds

2012 ◽  
Author(s):  
Yunzhi P. Yang
Keyword(s):  
Bone Regeneration ◽  
Functionally Graded ◽  
Segmental Bone

The association of human mesenchymal stem cells with BMP-7 improves bone regeneration of critical-size segmental bone defects in athymic rats

Bone ◽  
2010 ◽  
Vol 47 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Giorgio Burastero ◽  
Sonia Scarfì ◽  
Chiara Ferraris ◽  
Chiara Fresia ◽  
Nadia Sessarego ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Critical Size ◽  
Human Mesenchymal Stem Cells ◽  
Bone Defects ◽  
Segmental Bone ◽  
Segmental Bone Defects

Cambridge experience in spontaneous bone regeneration after traumatic segmental bone defect: a case series and review of literature

2020 ◽  
Vol 13 (4) ◽  
pp. e232482
Author(s):  
Ali Abdulkarim ◽  
Shu Yang Hu ◽  
Brendon R Walker ◽  
Matija Krkovic
Keyword(s):  
Bone Regeneration ◽  
Case Series ◽  
Patient Characteristics ◽  
High Energy ◽  
Long Bone ◽  
Review Of Literature ◽  
Segmental Bone Defect ◽  
Management Guidelines ◽  
Spontaneous Regeneration ◽  
Segmental Bone

High-energy traumatic long bone defects are some of the most challenging to reconstruct. Although cases of spontaneous bone regeneration in these defects have been reported, we are aware of no management guidelines or recommendations for when spontaneous bone regeneration should be considered a viable management option. We aim to identify how certain patient characteristics and surgical factors may help predict spontaneous bone regeneration. A total of 26 cases with traumatic segmental defects were treated at our institution, with eight cases (30.8%) undergoing spontaneous regeneration. We discuss four in detail. Six (75%) reported a degree of periosteal preservation, four (50%) were associated with traumatic brain injury and none were complicated by infection. The average time to spontaneous bone regeneration was 2.06 months. According to our cases, patients with favourable characteristics may benefit from delaying surgical treatment by 6 weeks to monitor for any signs of spontaneous bone formation.

A Novel Strategy Incorporated the Power of Mesenchymal Stem Cells to Allografts for Segmental Bone Tissue Engineering

2009 ◽  
Vol 18 (4) ◽  
pp. 433-441 ◽  
Author(s):  
Xiao Hui Zou ◽  
Hong Xin Cai ◽  
Zi Yin ◽  
Xiao Chen ◽  
Yang Zi Jiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Nude Mice ◽  
Bone Grafts ◽  
Great Promise ◽  
Differentiation Potential ◽  
Bone Allografts ◽  
Segmental Bone

Mesenchymal stem cells (MSCs) hold great promise for bone regeneration. However, the power of mesenchymal stem cells has not been applied to structural bone allografts in clinical practice. This study designed a new strategy to enhance the efficiency of allografts for segmental bone regeneration. Isolated MSCs were cultured to form a cell sheet. The MSC sheet was then wrapped onto structural allografts. The assembled structures were cultured in vitro to evaluate the differentiation potential of MSC sheet. The assembled structures were implanted subcutaneously into nude mice as well as into the segmental radius defect of rabbits to investigate the efficiency of MSC sheets to repopulate allografts for bone repair. MSC sheets, upon assembling on bone grafts, showed similar differentiation properties to the in situ periosteum in vitro. After implantation the MSC sheets accelerated the repopulation of bone grafts in nude mice. Moreover, MSC sheets induced thicker cortical bone formation and more efficient graft-to-bone end fusion at the segmental bone defects in rabbits. This study thus presented a novel, more efficient, and practical strategy for large weight-bearing bone reconstruction by using MSC sheets to deliver large number of MSCs to repopulate the bone allografts.

Application of α-TCP/HAp Functionally Graded Porous Beads for Bone Regenerative Scaffold

2012 ◽  
Vol 86 ◽  
pp. 63-69 ◽  
Author(s):  
A. Tamura ◽  
Teruo Asaoka ◽  
K. Furukawa ◽  
T. Ushida ◽  
T. Tateishi
Keyword(s):  
Blood Vessel ◽  
Bone Regeneration ◽  
Dissolution Rate ◽  
Surface Area ◽  
Functionally Graded ◽  
Living Body ◽  
Porous Beads

α-TCP/HAp functionally graded porous beads were prepared for use as a scaffold for bone regeneration. In this research, porous beads which have compositionally graded layer, from TCP of inner area to HAp of surface area, were fabricated. It is known that the dissolution rate of TCP is fast in compare with that of HAp in living body, thus the inner area would dissolve prior to the surface area. These beads to allow the penetration of cells and blood vessel into the inner area of beads following new bone regeneration. At present, conditions to fabricate the functionally graded porous beads have been established already, and experiments using cells [MC3T3-E1] are in progress.

Bone Regeneration Materials

2007 ◽  
Vol 342-343 ◽  
pp. 277-280 ◽  
Author(s):  
Masanori Kikuchi ◽  
M. Tanaka
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
High Strength ◽  
Autogenous Bone ◽  
High Porosity ◽  
Segmental Bone Defect ◽  
Membrane Bone ◽  
Segmental Bone ◽  
Co Precipitation ◽  
Gbr Membrane

Biomaterials Center is composed of five groups and collaborate each other to examine interdisciplinary fields of biomaterials. In the ceramics-based biomaterials research, we have been developing three novel bone regeneration materials, i.e., high-porosity hydroxyapatite (HAp) ceramics with high-strength, guided bone regeneration (GBR) membranes and bone-like nanocomposite composed of HAp and collagen. The GBR membrane composed of β-tricalcium phosphate and biodegradable copolymer of lactide, glycolide and ε-caprolactone has thermoplastic, pH auto-adjustment and enough mechanical property to protect an invasion of surrounding tissues. With the membrane, bone defect up to 20 × 10 × 10 mm3 in length in mandibles and segmental bone defect up to 20 mm in length in tibiae of beagles are regenerated without any additional bone fillers or cell transplantations. The bone-like nanocomposite is synthesized by a co-precipitation of HAp and collagen via their self-organization. The dense composite has a half to quarter mechanical strength (40 MPa) to cortical bone and the porous one demonstrates sponge-like viscoelasticity. The composites implanted into bone are incorporated into bone remodeling metabolism like as autogenous bone graft, i.e., they are resorbed by osteolasts followed by osteogenesis by osteoblasts.

Segmental bone regeneration using an rhBMP-2-loaded gelatin/nanohydroxyapatite/fibrin scaffold in a rabbit model

Biomaterials ◽  
2009 ◽  
Vol 30 (31) ◽  
pp. 6276-6285 ◽  
Author(s):  
Yue Liu ◽  
Yun Lu ◽  
Xuezhong Tian ◽  
Geng Cui ◽  
Yanmei Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Rabbit Model ◽  
Fibrin Scaffold ◽  
Segmental Bone
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