The Role of Retinal Determination Gene Network (RDGN) in Hormone Signaling Transduction and Prostate Tumorigenesis

2012 ◽  
Author(s):  
Kongming Wu
Keyword(s):  
Gene Network ◽  
Hormone Signaling ◽  
Signaling Transduction ◽  
Prostate Tumorigenesis ◽  
Retinal Determination ◽  
Retinal Determination Gene Network

scholarly journals How spiders make their eyes: Systemic paralogy and function of retinal determination network homologs in arachnids

2020 ◽  
Author(s):  
Guilherme Gainett ◽  
Jesús A. Ballesteros ◽  
Charlotte R. Kanzler ◽  
Jakob T. Zehms ◽  
John M. Zern ◽  
...  
Keyword(s):  
Expression Patterns ◽  
Single Copy ◽  
Parasteatoda Tepidariorum ◽  
Sine Oculis ◽  
Retinal Determination ◽  
Differential Gene ◽  
Cave Ecosystems ◽  
And Function ◽  
Retinal Determination Gene Network

AbstractArachnids are important components of cave ecosystems and display many examples of troglomorphisms, such as blindness, depigmentation, and elongate appendages. Little is known about how the eyes of arachnids are specified genetically, let alone the mechanisms for eye reduction and loss in troglomorphic arachnids. Additionally, paralogy of Retinal Determination Gene Network (RDGN) homologs in spiders has convoluted functional inferences extrapolated from single-copy homologs in pancrustacean models. Here, we investigated a sister species pair of Israeli cave whip spiders (Arachnopulmonata, Amblypygi, Charinus) of which one species has reduced eyes. We generated the first embryonic transcriptomes for Amblypygi, and discovered that several RDGN homologs exhibit duplications. We show that paralogy of RDGN homologs is systemic across arachnopulmonates (arachnid orders that bear book lungs), rather than being a spider-specific phenomenon. A differential gene expression (DGE) analysis comparing the expression of RDGN genes in field-collected embryos of both species identified candidate RDGN genes involved in the formation and reduction of eyes in whip spiders. To ground bioinformatic inference of expression patterns with functional experiments, we interrogated the function of three candidate RDGN genes identified from DGE in a spider, using RNAi in the spider Parasteatoda tepidariorum. We provide functional evidence that one of these paralogs, sine oculis/Six1 A (soA), is necessary for the development of all arachnid eye types. Our results support the conservation of at least one RDGN component across Arthropoda and establish a framework for investigating the role of gene duplications in arachnid eye diversity.

scholarly journals Probing the Drosophila retinal determination gene network in Tribolium (II): The Pax6 genes eyeless and twin of eyeless

2009 ◽  
Vol 333 (1) ◽  
pp. 215-227 ◽  
Author(s):  
Xiaoyun Yang ◽  
Markus Weber ◽  
Nazanin ZarinKamar ◽  
Nico Posnien ◽  
Frank Friedrich ◽  
...  
Keyword(s):  
Gene Network ◽  
Retinal Determination ◽  
Retinal Determination Gene Network

scholarly journals A Toggle-Switch and a Feed-Forward Loop Engage in the Control of the Drosophila Retinal Determination Gene Network

2019 ◽  
Vol 7 ◽  
Author(s):  
Máximo Sánchez-Aragón ◽  
Julia Cantisán-Gómez ◽  
Carlos M. Luque ◽  
Catarina Brás-Pereira ◽  
Carla S. Lopes ◽  
...  
Keyword(s):  
Gene Network ◽  
Toggle Switch ◽  
Feed Forward ◽  
Feed Forward Loop ◽  
Retinal Determination ◽  
Retinal Determination Gene Network
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