The Role of Crk Adaptor Proteins in Breast Tumorigenesis and Bone Metastasis

2012 ◽  
Author(s):  
Emily Bell
Keyword(s):  
Bone Metastasis ◽  
Adaptor Proteins ◽  
Breast Tumorigenesis

scholarly journals Studying the role of RANKL in breast cancer and bone metastasis mouse models

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100900
Author(s):  
Evi Gkikopoulou ◽  
Anthi Kolokotroni ◽  
Vagelis Rinotas ◽  
Melina Dragolia ◽  
Vasileios Ntafis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Mouse Models

scholarly journals Structure, Function, and Interactions of the HIV-1 Capsid Protein

Life ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 100
Author(s):  
Eric Rossi ◽  
Megan E. Meuser ◽  
Camille J. Cunanan ◽  
Simon Cocklin
Keyword(s):  
Life Cycle ◽  
Capsid Protein ◽  
Adaptor Proteins ◽  
Restriction Factors ◽  
Gag Polyprotein ◽  
Immunodeficiency Virus ◽  
Host Cell Factors ◽  
Hiv 1

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions with host cell factors. Capsid shields the reverse transcription complex from restriction factors while it enables trafficking to the nucleus by hijacking various adaptor proteins, such as FEZ1 and BICD2. In addition, the capsid facilitates the import and localization of the viral complex in the nucleus through interaction with NUP153, NUP358, TNPO3, and CPSF-6. In the later stages of the HIV-1 life cycle, CA plays an essential role in the maturation step as a constituent of the Gag polyprotein. In the final phase of maturation, Gag is cleaved, and CA is released, allowing for the assembly of CA into a fullerene cone, known as the capsid core. The fullerene cone consists of ~250 CA hexamers and 12 CA pentamers and encloses the viral genome and other essential viral proteins for the next round of infection. As research continues to elucidate the role of CA in the HIV-1 life cycle and the importance of the capsid protein becomes more apparent, CA displays potential as a therapeutic target for the development of HIV-1 inhibitors.

Overview paper: Pathogenesis and treatment of bone metastasis: Mouse models and role of the bone microenvironment

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S61
Author(s):  
T.J. Rosol ◽  
J.L. Werbeck ◽  
C.K. Martin ◽  
B.E. Hildreth ◽  
L.G. Lanigan ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Mouse Models ◽  
Bone Microenvironment

The role of internal fixation for long bone metastasis prior to impending fracture: an experimental model

2013 ◽  
Vol 18 (4) ◽  
pp. 659-666 ◽  
Author(s):  
Mohammad Ibrahim ◽  
Hidetomi Terai ◽  
Kentaro Yamada ◽  
Akinobu Suzuki ◽  
Hiromitsu Toyoda ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Internal Fixation ◽  
Experimental Model ◽  
Long Bone ◽  
Impending Fracture

scholarly journals Opening the LOX to bone metastasis: The role of secreted lysyl oxidase in skeletal recurrence of breast cancers

2015 ◽  
Vol 2 (4) ◽  
pp. 288-290 ◽  
Author(s):  
Maryam K. Mohammed ◽  
Connie Shao ◽  
Hue H. Luu ◽  
Rex C. Haydon
Keyword(s):  
Bone Metastasis ◽  
Lysyl Oxidase ◽  
Breast Cancers

scholarly journals The role of platelets and megakaryocytes in bone metastasis

2016 ◽  
Vol 5 (3) ◽  
pp. 109-111 ◽  
Author(s):  
Raphael Leblanc ◽  
Olivier Peyruchaud
Keyword(s):  
Bone Metastasis

scholarly journals Receptor Tyrosine Kinases in Kidney Development

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Renfang Song ◽  
Samir S. El-Dahr ◽  
Ihor V. Yosypiv
Keyword(s):  
Tyrosine Kinases ◽  
Molecular Mechanisms ◽  
Kidney Development ◽  
Receptor Tyrosine Kinases ◽  
Adaptor Proteins ◽  
Downstream Signaling ◽  
Arterial Blood ◽  
Intracellular Signal ◽  
Human Birth

The kidney plays a fundamental role in the regulation of arterial blood pressure and fluid/electrolyte homeostasis. As congenital anomalies of the kidney and urinary tract (CAKUT) constitute one of the most common human birth defects, improved understanding of the cellular and molecular mechanisms that lead to CAKUT is critical. Accumulating evidence indicates that aberrant signaling via receptor tyrosine kinases (RTKs) is causally linked to CAKUT. Upon activation by their ligands, RTKs dimerize, undergo autophosphorylation on specific tyrosine residues, and interact with adaptor proteins to activate intracellular signal transduction pathways that regulate diverse cell behaviours such as cell proliferation, survival, and movement. Here, we review the current understanding of role of RTKs and their downstream signaling pathways in the pathogenesis of CAKUT.

Sign in / Sign up

Export Citation Format

Share Document