Noninvasive Assessment of Renal Tumor Aggressiveness Using Hyperpolarized 13C MR

2012 ◽  
Author(s):  
Zhen Wang
Keyword(s):  
Renal Tumor ◽  
Tumor Aggressiveness ◽  
Hyperpolarized 13C ◽  
Noninvasive Assessment

scholarly journals Characterization of Distinctive In Vivo Metabolism between Enhancing and Non-Enhancing Gliomas Using Hyperpolarized Carbon-13 MRI

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 504
Author(s):  
Seunggwi Park ◽  
Hashizume Rintaro ◽  
Seul Kee Kim ◽  
Ilwoo Park
Keyword(s):  
Metabolic Imaging ◽  
Metabolic Profiles ◽  
Rodent Models ◽  
In Vivo Metabolism ◽  
Hyperpolarized 13C ◽  
Noninvasive Assessment ◽  
Diffuse Midline Glioma ◽  
Mr Spectroscopic Imaging

The development of hyperpolarized carbon-13 (13C) metabolic MRI has enabled the sensitive and noninvasive assessment of real-time in vivo metabolism in tumors. Although several studies have explored the feasibility of using hyperpolarized 13C metabolic imaging for neuro-oncology applications, most of these studies utilized high-grade enhancing tumors, and little is known about hyperpolarized 13C metabolic features of a non-enhancing tumor. In this study, 13C MR spectroscopic imaging with hyperpolarized [1-13C]pyruvate was applied for the differential characterization of metabolic profiles between enhancing and non-enhancing gliomas using rodent models of glioblastoma and a diffuse midline glioma. Distinct metabolic profiles were found between the enhancing and non-enhancing tumors, as well as their contralateral normal-appearing brain tissues. The preliminary results from this study suggest that the characterization of metabolic patterns from hyperpolarized 13C imaging between non-enhancing and enhancing tumors may be beneficial not only for understanding distinct metabolic features between the two lesions, but also for providing a basis for understanding 13C metabolic processes in ongoing clinical trials with neuro-oncology patients using this technology.

scholarly journals Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI

Cancers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 313 ◽  
Author(s):  
Renuka Sriram ◽  
Jeremy Gordon ◽  
Celine Baligand ◽  
Fayyaz Ahamed ◽  
Justin Delos Santos ◽  
...  
Keyword(s):  
Renal Cell ◽  
Renal Tumor ◽  
Lactate Production ◽  
Treatment Selection ◽  
Monocarboxylate Transporter ◽  
Renal Tumors ◽  
Biological Behavior ◽  
Tumor Aggressiveness ◽  
Human Renal Cell Carcinoma ◽  
Apparent Diffusion Coefficients

Optimal treatment selection for localized renal tumors is challenging due to their variable biological behavior and limited ability to pre-operatively assess their aggressiveness. We investigated hyperpolarized (HP) 13C pyruvate MRI to noninvasively assess tumor lactate production and compartmentalization, which are strongly associated with renal tumor aggressiveness. Orthotopic tumors were created in mice using human renal cell carcinoma (RCC) lines (A498, 786-O, UOK262) with varying expression of lactate dehydrogenase A (LDHA) which catalyzes the pyruvate-to-lactate conversion, and varying expression of monocarboxylate transporter 4 (MCT4) which mediates lactate export out of the cells. Dynamic HP 13C pyruvate MRI showed that the A498 tumors had significantly higher 13C pyruvate-to-lactate conversion than the UOK262 and 786-O tumors, corresponding to higher A498 tumor LDHA expression. Additionally, diffusion-weighted HP 13C pyruvate MRI showed that the A498 tumors had significantly higher 13C lactate apparent diffusion coefficients compared to 786-O tumors, with corresponding higher MCT4 expression, which likely reflects more rapid lactate export in the A498 tumors. Our data demonstrate the feasibility of HP 13C pyruvate MRI to inform on tumor lactate production and compartmentalization, and provide the scientific premise for future clinical investigation into the utility of this technique to noninvasively interrogate renal tumor aggressiveness and to guide treatment selection.

scholarly journals PDTM-20. NONINVASIVE ASSESSMENT OF TREATMENT RESPONSE FOR DIFFUSE INTRINSIC PONTINE GLIOMA USING HYPERPOLARIZED 13C METABOLIC IMAGING

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi194-vi194
Author(s):  
Ilwoo Park ◽  
Adam Autry ◽  
Xiaodong Yang ◽  
Yuying Zhai ◽  
Renuka Sriram ◽  
...  
Keyword(s):  
Treatment Response ◽  
Diffuse Intrinsic Pontine Glioma ◽  
Metabolic Imaging ◽  
Pontine Glioma ◽  
Hyperpolarized 13C ◽  
Noninvasive Assessment

scholarly journals DIPG-16. NONINVASIVE ASSESSMENT OF TREATMENT RESPONSE FOR DIFFUSE INTRINSIC PONTINE GLIOMA USING HYPERPOLARIZED 13C METABOLIC IMAGING

2017 ◽  
Vol 19 (suppl_4) ◽  
pp. iv8-iv8
Author(s):  
Ilwoo Park ◽  
Adam Elkhaled ◽  
Xiaodong Yang ◽  
Yuying Zhai ◽  
Renuka Sriram ◽  
...  
Keyword(s):  
Treatment Response ◽  
Diffuse Intrinsic Pontine Glioma ◽  
Metabolic Imaging ◽  
Pontine Glioma ◽  
Hyperpolarized 13C ◽  
Noninvasive Assessment

1526: Percutaneous Renal Tumor Cryoablation Under CT Guidance: Initial Clinical Experience

2005 ◽  
Vol 173 (4S) ◽  
pp. 413-413 ◽  
Author(s):  
Ajay Gupta ◽  
Mohamad E. Allaf ◽  
Christopher A. Warlick ◽  
Thomas W. Jarrett ◽  
David Y. Chan ◽  
...  
Keyword(s):  
Clinical Experience ◽  
Renal Tumor ◽  
Ct Guidance ◽  
Initial Clinical Experience

Noninvasive Assessment of Coronary Artery Disease – Anatomical versus Functional Imaging and the Marginal Role of Exercise Electrocardiograms

Praxis ◽  
2020 ◽  
Vol 109 (14) ◽  
pp. 1141-1149
Author(s):  
Martina Boscolo Berto ◽  
Dominik C. Benz ◽  
Christoph Gräni
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Functional Imaging ◽  
Clinical Aspects ◽  
Industrialized Countries ◽  
Coronary Syndromes ◽  
Pros And Cons ◽  
Noninvasive Assessment ◽  
Artery Disease ◽  
European Society Of Cardiology

Abstract. Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the industrialized countries. Assessment of symptomatic patients with suspected obstructive CAD is a common reason for a clinical visit. Noninvasive anatomical and functional imaging are established tools to rule-in and rule-out CAD, to assess the severity of disease and to determine the potential risk of future cardiovascular events. In this review, we discuss the updated Guidelines from the European Society of Cardiology on Chronic Coronary Syndromes and explore the different imaging modalities used in current clinical practice for the noninvasive assessment of CAD. The pros and cons of each method, especially comparing anatomical and functional testing, are presented. Furthermore we we address the practical clinical aspects in the selection of the optimal noninvasive tests according to clinical need.

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