Assessing the Role of Copy Number Variants in Prostate Cancer Risk and Progression Using a Novel Genome-Wide Screening Method

2011 ◽  
Author(s):  
Donna Lehman
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Copy Number ◽  
Screening Method ◽  
Copy Number Variants ◽  
Prostate Cancer Risk ◽  
Genome Wide

scholarly journals Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk

2012 ◽  
Vol 109 (17) ◽  
pp. 6686-6691 ◽  
Author(s):  
F. Demichelis ◽  
S. R. Setlur ◽  
S. Banerjee ◽  
D. Chakravarty ◽  
J. Y. H. Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Copy Number ◽  
Copy Number Variants ◽  
Prostate Cancer Risk ◽  
Low Frequency

scholarly journals Validation of copy number variants associated with prostate cancer risk and prognosis

2014 ◽  
Vol 32 (1) ◽  
pp. 44.e15-44.e20
Author(s):  
August Blackburn ◽  
Desiree Wilson ◽  
Jonathan Gelfond ◽  
Li Yao ◽  
Javier Hernandez ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Copy Number ◽  
Copy Number Variants ◽  
Prostate Cancer Risk

Hormonal Predictors of Prostate Cancer: A Meta-Analysis

2000 ◽  
Vol 18 (4) ◽  
pp. 847-847 ◽  
Author(s):  
Terrence Shaneyfelt ◽  
Rozita Husein ◽  
Glenn Bubley ◽  
Christos S. Mantzoros
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Confidence Interval ◽  
Population Distribution ◽  
Serum Insulin ◽  
Meta Analysis ◽  
Prostate Cancer Risk ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone

PURPOSE: Although there is strong circumstantial evidence that androgens are implicated in the etiology of prostate cancer, epidemiologic investigations have failed to demonstrate consistently that one or more steroid hormones are implicated. In contrast, recent epidemiologic studies unequivocally link serum insulin-like growth factor 1 (IGF-1) levels with risk for prostate cancer. METHODS: We have performed the first meta-analysis of all previously published studies on hormonal predictors of risk for prostate cancer. RESULTS: A meta-analysis restricted to studies that performed mutual adjustment for all measured serum hormones, age, and body mass index indicated that men whose total testosterone is in the highest quartile are 2.34 times more likely to develop prostate cancer (95% confidence interval, 1.30 to 4.20). In contrast, levels of dihydrotestosterone and estradiol do not seem to play a role of equal importance. The only study that provides multivariably adjusted sex hormone–binding globulin data indicates that this binding protein is inversely related to prostate cancer risk (odds ratio, 0.46; 95% confidence interval, 0.24 to 0.89). Finally, all three studies that examined the role of serum IGF-1 have consistently demonstrated a positive and significant association with prostate cancer risk that is similar in magnitude to that of testosterone. CONCLUSION: Men with either serum testosterone or IGF-1 levels in upper quartile of the population distribution have an approximately two-fold higher risk for developing prostate cancer.

scholarly journals Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population

2003 ◽  
Vol 89 (4) ◽  
pp. 691-696 ◽  
Author(s):  
H Nakazato ◽  
K Suzuki ◽  
H Matsui ◽  
N Ohtake ◽  
S Nakata ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Japanese Population ◽  
Prostate Cancer Risk
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