Breast Cancer Microvesicles as a Novel Plasma Biomarker and Therapeutic Target (IDEA)

Background: CASC15, one of long non-coding RNA, is involved in the regulation of many tumor biological processes, and is expected to become a new biological therapeutic target. This paper aims to elucidate the pathophysiological function of CASC15 in various tumors. Methods: The relationship between CASC15 and tumors was analyzed by searching references, and summarizes the specific pathophysiological mechanism of CASC15. Results: LncRNA CASC15 is closely related to tumor development, and has been shown to be abnormally high expressed in all kinds of tumors, including breast cancer, cervical cancer, lung cancer, hepatocellular carcinoma, gastric cancer, bladder cancer, colon cancer, colorectal cancer, cardiac hypertrophy, intrahepatic cholangiocarcinoma, leukemia, melanoma, tongue squamous cell carcinoma, nasopharyngeal carcinoma. However, CASC15 has been found to be downexpressed abnormally in ovarian cancer, glioma and neuroblastoma. Besides, it is identified that CASC15 can affect the proliferation, invasion and apoptosis of tumors. Conclusion: LncRNA CASC15 has the potential to become a new therapeutic target or marker for a variety of tumors.

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Clusters, Assemblies and Aggregates of Tumor Cells in the Blood of Breast Cancer Patients; Composition, Mode of Action, Detection and Impact on Metastasis and Survival

International Journal of Translational Medicine ◽

10.3390/ijtm1010005 ◽

2021 ◽

Vol 1 (1) ◽

pp. 55-68

Author(s):

Urszula Smietanka ◽

Małgorzata Szostakowska-Rodzos ◽

Sylwia Tabor ◽

Anna Fabisiewicz ◽

Ewa A. Grzybowska

Keyword(s):

Breast Cancer ◽

Tumor Cell ◽

Cancer Patients ◽

Tumor Cells ◽

Diagnostic Tool ◽

Therapeutic Target ◽

Mode Of Action ◽

Breast Cancer Patients ◽

Single Ctcs ◽

Methods Of Isolation

Circulating tumor cells (CTCs) are gaining momentum as a diagnostic tool and therapeutic target. CTC clusters are more metastatic, but harder to study and characterize, because they are rare and the methods of isolation are mostly focused on single CTCs. This review highlights the recent advances to our understanding of tumor cell clusters with the emphasis on their composition, origin, biology, methods of detection, and impact on metastasis and survival. New approaches to therapy, based on cluster characteristics are also described.

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