DNA Methylation as an Epigenetic Factor in the Development and Progression of Polycythemia Vera

2009 ◽  
Author(s):  
Jean-Pierre Issa
Keyword(s):  
Dna Methylation ◽  
Polycythemia Vera ◽  
Epigenetic Factor

scholarly journals PS1451 THE EFFECT OF HYDROXYUREA ON DNA METHYLATION AND GENE EXPRESSION IN POLYCYTHEMIA VERA AND ESSENTIAL THROMBOCYTHEMIA

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 667-668
Author(s):  
S. Contreras ◽  
A. Rocha ◽  
W. Duke ◽  
R. Schulz ◽  
A. Mullally ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Polycythemia Vera ◽  
Essential Thrombocythemia

scholarly journals DNA Methylation-Governed Gene Expression in Autoimmune Arthritis

2019 ◽  
Vol 20 (22) ◽  
pp. 5646 ◽  
Author(s):  
Barbara Brandt ◽  
Shima Rashidiani ◽  
Ágnes Bán ◽  
Tibor A. Rauch
Keyword(s):  
Dna Methylation ◽  
Joint Destruction ◽  
Molecular Structures ◽  
New Drugs ◽  
Epigenetic Alterations ◽  
Epigenetic Factors ◽  
Biological Targets ◽  
Epigenetic Factor ◽  
Oral Pathogens ◽  
Inflammatory Autoimmune Disease

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease hallmarked by progressive and irreversible joint destruction. RA pathogenesis is a T cell-regulated and B cell-mediated process in which activated lymphocyte-produced chemokines and cytokines promote leukocyte infiltration that ultimately leads to destruction of the joints. There is an obvious need to discover new drugs for RA treatment that have different biological targets or modes of action than the currently employed therapeutics. Environmental factors such as cigarette smoke, certain diet components, and oral pathogens can significantly affect gene regulation via epigenetic factors. Epigenetics opened a new field for pharmacology, and DNA methylation and histone modification-implicated factors are feasible targets for RA therapy. Exploring RA pathogenesis involved epigenetic factors and mechanisms is crucial for developing more efficient RA therapies. Here we review epigenetic alterations associated with RA pathogenesis including DNA methylation and interacting factors. Additionally, we will summarize the literature revealing the involved molecular structures and interactions. Finally, potential epigenetic factor-based therapies will be discussed that may help in better management of RA in the future.

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

15 LONGITUDINAL EVALUATION OF MUCOSAL DNA METHYLATION IN ULCERATIVE COLITIS SHOWS DISEASE-SPECIFIC CHANGES

2020 ◽  
Vol 158 (3) ◽  
pp. S50-S51
Author(s):  
Suresh Venkateswaran ◽  
Varun Kilaru ◽  
Hari Somineni ◽  
Jason Matthews ◽  
Jeffrey Hyams ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dna Methylation ◽  
Longitudinal Evaluation ◽  
Disease Specific

Decreased Free Protein S Levels in Polycythemia Vera

1990 ◽  
Vol 64 (01) ◽  
pp. 177-178 ◽  
Author(s):  
M Zoppi ◽  
M Furlan ◽  
G Brun del Re ◽  
W Wuillemin ◽  
B Lämmle
Keyword(s):  
Polycythemia Vera ◽  
Protein S ◽  
Free Protein
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