MR-Guided Pulsed High-Intensity Focused Ultrasound Enhancement of Gene Therapy Combined With Androgen Deprivation and Radiotherapy for Prostate Cancer Treatment

2009 ◽  
Author(s):  
Lili Chen
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Cancer Treatment ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Androgen Deprivation ◽  
High Intensity Focused Ultrasound ◽  
Prostate Cancer Treatment ◽  
Ultrasound Enhancement

scholarly journals MR Guided Pulsed High Intensity Focused Ultrasound Enhancement of Docetaxel Combined with Radiotherapy for Prostate Cancer Treatment

2018 ◽  
Author(s):  
Lili Chen ◽  
Alan Pollack
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Tumor Growth ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Tumor Growth Inhibition ◽  
Prostate Cancer Treatment ◽  
Ultrasound Enhancement ◽  
Enhance Tumor Growth

This project will determine whether (1) HIFU increases the cellular update of docetaxel in vivo, and (2) the increased uptake of docetaxel combined with RT will enhance tumor growth inhibition. We will determine the optimal HIFU parameters, quantify the update of docetaxel using a radioactive tritiated docetaxel and evaluate the efficacy of docetaxel+RT in inhibiting prostate tumor growth in vivo. This research has the potential to improve local control and may also have effects on distant microscopic disease by promoting immune response, which will also lay the foundation for other tumor models and studies on gene therapy and thrombolytic drugs.

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