Mechanisms of Rerg-Mediated Tumor Suppression in Breast Cancer

2008 ◽  
Author(s):  
Ariella B. Hanker ◽  
Channing J. Der
Keyword(s):  
Breast Cancer ◽  
Tumor Suppression

scholarly journals MAP1S Controls Breast Cancer Cell TLR5 Signaling Pathway and Promotes TLR5 Signaling-based Tumor Suppression

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86839 ◽  
Author(s):  
Ming Shi ◽  
Yuanfei Yao ◽  
Fang Han ◽  
Yiqun Li ◽  
Yu Li
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Tumor Suppression

scholarly journals Rare Copy Number Variants Observed in Hereditary Breast Cancer Cases Disrupt Genes in Estrogen Signaling and TP53 Tumor Suppression Network

PLoS Genetics ◽  
2012 ◽  
Vol 8 (6) ◽  
pp. e1002734 ◽  
Author(s):  
Katri Pylkäs ◽  
Mikko Vuorela ◽  
Meeri Otsukka ◽  
Anne Kallioniemi ◽  
Arja Jukkola-Vuorinen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppression ◽  
Hereditary Breast Cancer ◽  
Copy Number ◽  
Copy Number Variants ◽  
Estrogen Signaling

scholarly journals miR‐16 enhances miR‐302/367‐induced reprogramming and tumor suppression in breast cancer cells

IUBMB Life ◽  
2020 ◽  
Vol 72 (5) ◽  
pp. 1075-1086 ◽  
Author(s):  
Moslem Hoseinbeyki ◽  
Masoumeh F. Taha ◽  
Arash Javeri
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Tumor Suppression ◽  
Breast Cancer Cells

scholarly journals HER2 Silences Tumor Suppression in Breast Cancer Cells by Switching Expression of C/EBPβ Isoforms

2010 ◽  
Vol 70 (23) ◽  
pp. 9927-9936 ◽  
Author(s):  
Anna Arnal-Estapé ◽  
Maria Tarragona ◽  
Mònica Morales ◽  
Marc Guiu ◽  
Cristina Nadal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Tumor Suppression ◽  
Breast Cancer Cells

Corrigendum to “Tumor suppression effects of myoepithelial cells on mice breast cancer” [Eur. J. Pharmacol. 765 (2015) 171–178]

2016 ◽  
Vol 782 ◽  
pp. 119
Author(s):  
Baharak Farhangi ◽  
Mostafa Latifpour ◽  
Ali Mohammad Alizadeh ◽  
Hamid Khodayari ◽  
Saeed Khodayari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppression ◽  
Myoepithelial Cells ◽  
Suppression Effects

scholarly journals Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Young Jin Moon ◽  
Daniel A. Brazeau ◽  
Marilyn E. Morris
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Tumor Suppression ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cellular Proliferation ◽  
Phenethyl Isothiocyanate ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Phenethyl isothiocyanate (PEITC), a component in cruciferous vegetables, can block chemical carcinogenesis in animal models. Our objective was to determine the effect of treatment with PEITC on gene expression changes in MCF-7 human breast cancer cells in order to evaluate potential mechanisms involved in its chemopreventive effects. MCF-7 cells were treated for 48 hours with either PEITC (3 μM) or the vehicle. Total RNA was extracted from cell membrane preparations, and labeled cDNA's representing the mRNA pool were reverse-transcribed directly from total RNA isolated for use in the microarray hybridizations. Two specific human GE Array Kits (Superarray Inc.) that both contain 23 marker genes, related to signal transduction pathways or cancer/tumor suppression, plus 2 housekeeping genes (β-actin and GAPDH), were utilized. Arrays from treated and control cells (n=4per group) were evaluated using a Student'st-test. Gene expression was significantly induced for tumor protein p53 (p53), cyclin-dependent kinase inhibitor 1C (p57 Kip2), breast cancer Type 2 early onset (BRCA2), cAMP responsive element binding protein 2 (ATF-2), interleukin 2 (IL-2), heat shock 27 KD protein (hsp27), and CYP19 (aromatase). Induction of p57 Kip2, p53, BRCA2, IL-2, and ATF-2 would be expected to decrease cellular proliferation and increase tumor suppression and/or apoptosis. PEITC treatment produced significant alterations in some genes involved in tumor suppression and cellular proliferation/apoptosis that may be important in explaining the chemopreventive effects of PEITC.

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