Computation and Modeling for Laser Propagation in Ocular Tissues

2007 ◽  
Author(s):  
Dhiraj K. Sardar ◽  
Raylon M. Yow ◽  
Deepthi Takkalapally ◽  
Robert J. Thomas
Keyword(s):  
Ocular Tissues ◽  
Laser Propagation

TO ANALYZE THE EFFECT OF DAMAGE TO OTHER OCULAR TISSUES ON VISUAL OUTCOME AFTER TRAUMATIC CATARACT SURGERY.

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Mita V. Joshi ◽  
Dr. Sudhir Mahashabde
Keyword(s):  
Visual Outcome ◽  
Corneal Opacity ◽  
Research Centre ◽  
Traumatic Cataract ◽  
Visual Axis ◽  
College Hospital ◽  
Ocular Tissues ◽  
Department Of Ophthalmology ◽  
Ocular Injuries ◽  
Final Visual Outcome

All patient coming to Index Medical College Hospital & Research Centre, Indore operated in Department of Ophthalmology for traumatic cataract due to various injuries Result: Of the 37 patients, 19 patients (51%) showed corneal/ corneal sclera injury. 10 cases had injury to iris in the form of spincter tear, traumatic mydriasis, iris incarceration, floppy iris, posterior and anterior synechiae. Subluxation of lens was seen in 2 cases and Dislocation of lens was in 1 cases. 3 cases had corneal opacity. Old retinal detachment was seen in 1 (3%) case. Out of 30 cases who had associated ocular injuries, 3 cases had vision of HM, 07 cases had vision of CF-ctf – CF-3’, 01 cases had vision of 5/60, 07 cases had vision of 6/60-6/36, 03 cases had vision of 6/24-6/18, 09 cases had vision of 6/12-6/6. Out of 7 cases without associated in injury, 2 cases had vision of 6/24-6/18, 05 cases had vision of 6/12-6/6. Conclusion: Corneal scarring obstructing the visual axis as well as by inducing irregular astigmatism formed an important cause of poor visual outcome in significant number of cases. Irreversible posterior segment damage lead to impaired vision case. The final visual outcome showed good result however the final visual outcome depends upon the extent of associated ocular injuries. Effective Intervention and management are the key points in preventing monocular blindness due to traumatic cataract. Keywords: Ocular, Tissues, Traumatic, Cataract & Surgery.

A first-order model of thermal lensing of laser propagation in the eye and implications for laser safety

2005 ◽  
Author(s):  
Robert J. Thomas ◽  
Rebecca L. Vincelette ◽  
Gavin D. Buffington ◽  
Amber D. Strunk ◽  
Michael A. Edwards ◽  
...  
Keyword(s):  
Thermal Lensing ◽  
Order Model ◽  
Laser Safety ◽  
First Order ◽  
Laser Propagation

Stratospheric Laser Propagation

2002 ◽  
Author(s):  
Robert R. Beland
Keyword(s):  
Laser Propagation

Progress in Laser Propagation in a Maritime Environment at the Naval Research Laboratory

2005 ◽  
Author(s):  
G. C. Gilbreath ◽  
W. S. Rabinovich ◽  
C. I. Moore ◽  
H. R. Burris ◽  
R. Mahon ◽  
...  
Keyword(s):  
Research Laboratory ◽  
Naval Research Laboratory ◽  
Naval Research ◽  
Laser Propagation ◽  
Maritime Environment

Optical Turbulence Model for Laser Propagation and Imaging Applications

2004 ◽  
Author(s):  
E. S. Oh ◽  
J. C. Ricklin ◽  
G. C. Gilbreath ◽  
N Vallestero ◽  
Eaton J. ◽  
...  
Keyword(s):  
Turbulence Model ◽  
Optical Turbulence ◽  
Laser Propagation

Differential Expression of Sumoylation Enzymes SAE1, U BA2, UBC9, PIAS1 and RanBP2 in Major Ocular Tissues of Mouse Eye

2019 ◽  
Vol 18 (6) ◽  
pp. 376-382 ◽  
Author(s):  
Qian Nie ◽  
Lan Yang ◽  
Wenjie Qing ◽  
Jie Xie ◽  
Xiaodong Gong ◽  
...  
Keyword(s):  
Differential Expression ◽  
Ocular Tissues

scholarly journals Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 744
Author(s):  
Ijeoma F. Uchegbu ◽  
Jan Breznikar ◽  
Alessandra Zaffalon ◽  
Uche Odunze ◽  
Andreas G. Schätzlein
Keyword(s):  
Polymeric Micelles ◽  
Rabbit Model ◽  
Penetration Enhancer ◽  
Hydrophobic Drugs ◽  
Ocular Tissues ◽  
Ocular Penetration ◽  
Self Assembling ◽  
Similar Dose ◽  
Oil In Water ◽  
The Stability

Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hydrophobic drug, cyclosporine A (CsA), a non-irritant ocular penetration enhancer is showcased, which may be used for the formulation of hydrophobic actives. The activity of this penetration enhancer is demonstrated in a healthy rabbit model. The Molecular Envelope Technology (MET) polymer (N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan), a self-assembling, micelle-forming polymer, was used to formulate CsA into sterile filtered nanoparticulate eye drop formulations and the stability of the formulation tested. Healthy rabbits were dosed with a single dose of a MET–CsA (NM133) 0.05% formulation and ocular tissues analyzed. Optically clear NM133 formulations were prepared containing between 0.01–0.1% w/v CsA and 0.375–0.75% w/v MET polymer. NM133 0.01%, NM133 0.02% and NM133 0.05% were stable for 28 days when stored at refrigeration temperature (5–6 °C) and room temperature (16–23 °C), but there was evidence of evaporation of the formulation at 40 °C. There was no change in drug content when NM133 0.05% was stored for 387 days at 4 °C. On topical dosing to rabbits, corneal, conjunctival and scleral AUC0–24 levels were 25,780 ng.h g−1, 12,046 ng.h g−1 and 5879 ng.h g−1, respectively, with NM133 0.05%. Meanwhile, a similar dose of Restasis 0.05% yielded lower values of 4726 ng.h/g, 4813 ng.h/g and 1729 ng.h/g for the drug corneal, conjunctival and scleral levels, respectively. NM133 thus delivered up to five times more CsA to the ocular surface tissues when compared to Restasis. The MET polymer was non-irritant up to a concentration of 4% w/v. The MET polymer is a non-irritant ocular penetration enhancer that may be used to deliver hydrophobic drugs in optically clear topical ocular formulations.

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