Signaling Crosstalk: A Live in Situ Analysis of the Temporal and Spatial Regulation of Key Pathways in Human Breast Cancer Progression

2007 ◽  
Author(s):  
Aaron Boudreau
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Human Breast ◽  
Signaling Crosstalk ◽  
Spatial Regulation ◽  
Temporal And Spatial ◽  
Key Pathways

scholarly journals Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers

2012 ◽  
Vol 72 (9) ◽  
pp. 2428-2439 ◽  
Author(s):  
Tamar Geiger ◽  
Stephen F. Madden ◽  
William M. Gallagher ◽  
Juergen Cox ◽  
Matthias Mann
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Prognostic Markers ◽  
Breast Cancer Progression ◽  
Human Breast

scholarly journals Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 29 ◽  
Author(s):  
Jyun-Yuan Huang ◽  
Yen-Yun Wang ◽  
Steven Lo ◽  
Ling-Ming Tseng ◽  
Dar-Ren Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Akt Pathway ◽  
Adipose Derived Stem Cells ◽  
Human Breast ◽  
Akt Inhibitor ◽  
Promoting Effect

Adipose-derived stem cells (ADSCs) have been implicated in tumor growth and metastasis in breast cancer. ADSCs exhibit tumor tropism, and are of increasing clinical relevance due to the autologous fat grafting for breast reconstruction. Although we have previously shown that a high level of the adipocytokine visfatin in human breast cancer tissues correlated with tumor progression mediated by cAbl and STAT3, the effects of visfatin in the tumor microenvironment are unclear. To understand how visfatin modulates breast cancer within the tumor-stromal environment, we examined determinants of breast cancer progression using a visfatin-primed ADSCs-tumor co-culture model. ADSCs were isolated from tumor-free adipose tissue adjacent to breast tumors. ADSCs were treated with or without visfatin for 48 h and then collected for co-culture with breast cancer cell line MDA-MB-231 for 72 h in a transwell system. We found that the MDA-MB-231 cells co-cultured with visfatin-treated ADSCs (vADSCs) had higher levels of cell viability, anchorage independent growth, migration, invasion, and tumorsphere formation than that co-cultured with untreated ADSCs (uADSCs). Growth differentiation factor 15 (GDF15) upregulation was found in the co-culture conditioned medium, with GDF15 neutralizing antibody blocking the promoting effect on MDA-MB-231 in co-culture. In addition, a GDF15-induced AKT pathway was found in MDA-MB-231 and treatment with PI3K/AKT inhibitor also reversed the promoting effect. In an orthotopic xenograft mouse model, MDA-MB-231 co-injected with vADSCs formed a larger tumor mass than with uADSCs. Positive correlations were noted between visfatin, GDF15, and phosphor-AKT expressions in human breast cancer specimens. In conclusion, visfatin activated GDF15-AKT pathway mediated via ADSCs to facilitate breast cancer progression.

The role of microRNAs in human breast cancer progression

Tumor Biology ◽  
2014 ◽  
Vol 35 (7) ◽  
pp. 6235-6244 ◽  
Author(s):  
WenCheng Zhang ◽  
Jinbo Liu ◽  
Guangshun Wang
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Human Breast

scholarly journals Cytogenetic and cDNA Microarray Expression Analysis of MCF10 Human Breast Cancer Progression Cell Lines

2009 ◽  
Vol 69 (14) ◽  
pp. 5946-5953 ◽  
Author(s):  
Narasimharao V. Marella ◽  
Kishore S. Malyavantham ◽  
Jianmin Wang ◽  
Sei-ichi Matsui ◽  
Ping Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Progression ◽  
Expression Analysis ◽  
Cdna Microarray ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Human Breast ◽  
Microarray Expression Analysis ◽  
Microarray Expression

scholarly journals Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression

2009 ◽  
Vol 120 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Jiaqi Fu ◽  
Amy M. Weise ◽  
Josie L. Falany ◽  
Charles N. Falany ◽  
Bryan J. Thibodeau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Culture ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Human Breast ◽  
Cell Culture Model ◽  
Culture Model
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