Regulation of Progesterone Receptors in Normal and Breast Cancer Cells through Differential Expression of microRNAs

2006 ◽  
Author(s):  
Eileen McGowan
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Differential Expression ◽  
Breast Cancer Cells ◽  
Progesterone Receptors

Differential expression and androgen regulation of microRNA molecules in breast cancer cells

2016 ◽  
Author(s):  
Mamoun Ahram ◽  
Rand Zaza ◽  
Ebtihal Mustafa ◽  
Heba Jarrar ◽  
Razan Al-Saber ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Differential Expression ◽  
Breast Cancer Cells ◽  
Androgen Regulation

Differential Expression of MiRNAs in Antiestrogen-Sensitive MCF-7vs.Antiestrogen-Resistant LY2 Breast Cancer Cells

2011 ◽  
pp. P3-68-P3-68
Author(s):  
Tissa T Manavalan ◽  
Yun Teng ◽  
Savitri N Appana ◽  
Susmita Datta ◽  
Theodore S Kalbfleisch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Differential Expression ◽  
Breast Cancer Cells

scholarly journals Differential expression of genes in human normal and breast cancer cells determined by microarray technique

10.1038/14353 ◽  
1999 ◽  
Vol 23 (S3) ◽  
pp. 59-59
Author(s):  
Suxing Liu ◽  
Qun Wu ◽  
Paul Kirschmeier ◽  
Terri McClanahan ◽  
Johnathan Greene ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Differential Expression ◽  
Breast Cancer Cells ◽  
Expression Of Genes ◽  
Microarray Technique ◽  
Differential Expression Of Genes

scholarly journals ZFHX3 Promotes the Proliferation and Tumor Growth of ER-Positive Breast Cancer Cells Likely by Enhancing Stem-Like Features and MYC and TBX3 Transcription

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3415
Author(s):  
Ge Dong ◽  
Gui Ma ◽  
Rui Wu ◽  
Jinming Liu ◽  
Mingcheng Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Molecular Mechanisms ◽  
Mammary Epithelial Cells ◽  
Progesterone Receptors ◽  
Mammary Epithelial ◽  
Luciferase Reporter ◽  
Mammosphere Formation

Breast cancer is a common malignancy, but the understanding of its cellular and molecular mechanisms is limited. ZFHX3, a transcription factor with many homeodomains and zinc fingers, suppresses prostatic carcinogenesis but promotes tumor growth of liver cancer cells. ZFHX3 regulates mammary epithelial cells’ proliferation and differentiation by interacting with estrogen and progesterone receptors, potent breast cancer regulators. However, whether ZFHX3 plays a role in breast carcinogenesis is unknown. Here, we found that ZFHX3 promoted the proliferation and tumor growth of breast cancer cells in culture and nude mice; and higher expression of ZFHX3 in human breast cancer specimens was associated with poorer prognosis. The knockdown of ZFHX3 in ZFHX3-high MCF-7 cells decreased, and ZFHX3 overexpression in ZFHX3-low T-47D cells increased the proportion of breast cancer stem cells (BCSCs) defined by mammosphere formation and the expression of CD44, CD24, and/or aldehyde dehydrogenase 1. Among several transcription factors that have been implicated in BCSCs, MYC and TBX3 were transcriptionally activated by ZFHX3 via promoter binding, as demonstrated by luciferase-reporter and ChIP assays. These findings suggest that ZFHX3 promotes breast cancer cells’ proliferation and tumor growth likely by enhancing BCSC features and upregulating MYC, TBX3, and others.

scholarly journals Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells

2011 ◽  
Vol 313 (1) ◽  
pp. 26-43 ◽  
Author(s):  
Tissa T. Manavalan ◽  
Yun Teng ◽  
Savitri N. Appana ◽  
Susmita Datta ◽  
Theodore S. Kalbfleisch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Differential Expression ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Microrna Expression ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Tamoxifen Resistant ◽  
Mcf 7
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