PSMA-Targeted Nano-Conjugates as Dual-Modality (MRI/PET) Imaging Probes for the Noninvasive Detection of Prostate Cancer

2006 ◽  
Author(s):  
Xiankai Sun
Keyword(s):  
Prostate Cancer ◽  
Pet Imaging ◽  
Noninvasive Detection ◽  
Dual Modality ◽  
Imaging Probes

scholarly journals Novel Strategy for Preparing Dual-Modality Optical/PET Imaging Probes via Photo-Click Chemistry

2016 ◽  
Vol 27 (5) ◽  
pp. 1200-1204 ◽  
Author(s):  
Lingyi Sun ◽  
Jiule Ding ◽  
Wei Xing ◽  
Yongkang Gai ◽  
Jing Sheng ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Pet Imaging ◽  
Dual Modality ◽  
Imaging Probes ◽  
Novel Strategy

Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer

Nanomedicine ◽  
2020 ◽  
Vol 15 (30) ◽  
pp. 2901-2916
Author(s):  
Yunkai Zhu ◽  
Ying Sun ◽  
Weiyong Liu ◽  
Wenbin Guan ◽  
Huanhuan Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Physical Property ◽  
Prostate Specific Membrane Antigen ◽  
Core Size ◽  
Dual Modality ◽  
Imaging Probes ◽  
Dual Modality Imaging ◽  
Histopathologic Findings ◽  
Specific Membrane ◽  
Psma Expression

Aim: To design MRI/ultrasound (US) dual modality imaging probes with optimized size for prostate cancer imaging by targeting prostate-specific membrane antigen (PSMA). Materials & methods: The PSMA-targeting polypeptide-nanobubbles (PP-NBs) with core size of 400 and 700 nm were fabricated and evaluated. Results: With excellent physical property and specificity, PP-NBs of both core size could image PSMA expression in prostate cancer xenografts. Particularly, 400 nm PP-NBs generated higher PSMA-specific MRI/US dual modality contrast enhancement than 700 nm PP-NBs in correlation with histopathologic findings. Conclusion: Benefit from the smaller core size, 400 nm PP-NBs had higher permeability and specificity than 700 nm PP-NBs, hence producing better PSMA-specific MRI/US dual modality imaging.

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