Enhancement of Tumor Immunotherapy by Blockade of a Prostate Tumor Derived Immunosuppressive Factor

2006 ◽  
Author(s):  
Xu Hui
Keyword(s):  
Tumor Immunotherapy ◽  
Prostate Tumor ◽  
Immunosuppressive Factor

960: Is Race a Prognostic Factor of Prostate Tumor Burden and Outcome in the PSA Era: The Duke Experience 2006

2006 ◽  
Vol 175 (4S) ◽  
pp. 310-310
Author(s):  
Nicholas J. Fitzsimons ◽  
Leon L. Sun ◽  
Thomas J. Polascik ◽  
Vladimir Mouraviev ◽  
Craig F. Donatucci ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Tumor Burden ◽  
Prostate Tumor

442: Stromal Hedgehog Pathway Activity Accelerates Prostate Tumor Growth

2006 ◽  
Vol 175 (4S) ◽  
pp. 143-143
Author(s):  
Aubie Shaw ◽  
Jerry Gipp ◽  
Wade Bushman
Keyword(s):  
Tumor Growth ◽  
Prostate Tumor ◽  
Hedgehog Pathway ◽  
Pathway Activity

The Fibrinolytic System in Experimental Prostate Tumor

1986 ◽  
Vol 56 (02) ◽  
pp. 133-136 ◽  
Author(s):  
Hamid Al-Mondhiry ◽  
Joseph Drago ◽  
Mary J Bartholomew
Keyword(s):  
Prostate Cancer ◽  
Plasminogen Activator ◽  
Disseminated Intravascular Coagulation ◽  
Transitional Cell ◽  
Prostate Tumor ◽  
Control Groups ◽  
Transitional Cell Bladder Carcinoma ◽  
Tumor Growth And Metastasis ◽  
Metastatic Prostate Carcinoma ◽  
Sustained Activation

SummaryHypofibrinogenemia and disseminated intravascular coagulation are common events in patients with metastatic prostate carcinoma. This study tests the hypothesis that prostate tumor growth and metastasis is associated with sustained activation of fibrinolysis secondary to increased release of plasminogen activator. We implanted an androgen-insensitive prostate tumor into an inbred strain of rats and serially measured plasminogen, plasminogen activator, plasmin and fibrinogen. Control groups included animals without tumor and a group implanted with transitional cell bladder carcinoma, a locally infiltrating tumor not usually associated with hemostatic complications. Our results showed a significant and steady rise in plasma plasminogen activator, plasmin and fibrinogen levels in animals implanted with prostate cancer. This, however, is not specific for prostate tumor. Similar, perhaps more profound changes were noted in animals implanted with the transitional cell carcinoma.

Effects of X-Ray Exposure on Some CMI Regulatory Cytokines in Technicians Serum Samples

2018 ◽  
Vol 9 (4) ◽  
Author(s):  
Weam S Al-Hamadany
Keyword(s):  
Clinical Status ◽  
Cell Mediated Immunity ◽  
Normal Range ◽  
Serum Samples ◽  
X Ray ◽  
Immunosuppressive Factor ◽  
Elisa Technique ◽  
Immunological Process ◽  
Field Workers ◽  
Tomography Scan

Ionizing radiation considered as an immunosuppressive factor upon over dose of exposure. Radiation field workers usually following a periodic checkup to monitor changes in their clinical status. Cell Mediated Immunity (CMI) has an important cytokines that regulate this specific immunological process. This study estimated the Interleukins (IL-2, IL-12 and IL-18) levels in serum samples using ELISA technique. Serum samples were collected from X-ray Technicians (Radiography, Fluoroscopy and Computed Tomography Scan Technicians) working in AL-Muthanna governorate hospitals. A total of (60) technicians and (30) control were involved in this research. Results showed significant decrease in IL-2 levels and increase in IL-18 levels in test groups (technicians) as compared with controls. While, IL-12 levels did not show a difference; all obtained values were within normal range. Overdose of X-ray exposure caused CMI suppression via disturbing the levels of critical cytokines (IL-2 and IL-18) leading to CMI loss regulation.

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