In-Vivo Characterization of Mammalian Polarity Genes as Novel Tumor Suppressors Involved in Breast Cancer Development and Progression in a Mouse Model

2006 ◽  
Author(s):  
Avi Z. Rosenberg
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Tumor Suppressors ◽  
Cancer Development ◽  
Breast Cancer Development ◽  
In Vivo Characterization

scholarly journals In Vivo Characterization of Changing Blood-Tumor Barrier Permeability in a Mouse Model of Breast Cancer Metastasis

2011 ◽  
Vol 46 (11) ◽  
pp. 718-725 ◽  
Author(s):  
Dean B. Percy ◽  
Emeline J. Ribot ◽  
Yuhua Chen ◽  
Catherine McFadden ◽  
Carmen Simedrea ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Barrier Permeability ◽  
In Vivo Characterization

scholarly journals MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 942
Author(s):  
Mei Qi Kwa ◽  
Rafael Brandao ◽  
Trong H. Phung ◽  
Jianfeng Ge ◽  
Giuseppe Scieri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression Signature ◽  
Genomic Analysis ◽  
Cancer Development ◽  
Breast Cancer Cell Lines ◽  
Normal Mammary Gland ◽  
Breast Cancers ◽  
Human Breast ◽  
Breast Cancer Development

MRCKα is a ubiquitously expressed serine/threonine kinase involved in cell contraction and F-actin turnover, which is highly amplified in human breast cancer and part of a gene expression signature for bad prognosis. Nothing is known about the in vivo function of MRCKα. To explore MRCKα function in development and in breast cancer, we generated mice lacking a functional MRCKα gene. Mice were born close to the Mendelian ratio and showed no obvious phenotype including a normal mammary gland formation. Assessing breast cancer development using the transgenic MMTV-PyMT mouse model, loss of MRCKα did not affect tumor onset, tumor growth and metastasis formation. Deleting MRCKα and its related family member MRCKβ in two triple-negative breast cancer cell lines resulted in reduced invasion of MDA-MB-231 cells, but did not affect migration of 4T1 cells. Further genomic analysis of human breast cancers revealed that MRCKα is frequently co-amplified with the oncogenes ARID4B and AKT3 which might contribute to the prognostic value of MRCKα expression. Collectively, these data suggest that MRCKα might be a prognostic marker for breast cancer, but probably of limited functional importance.

scholarly journals Multiparametric Spectroscopic Photoacoustic Imaging of Breast Cancer Development in a Transgenic Mouse Model

Theranostics ◽  
2014 ◽  
Vol 4 (11) ◽  
pp. 1062-1071 ◽  
Author(s):  
Katheryne E. Wilson ◽  
Sunitha V. Bachawal ◽  
Lu Tian ◽  
Jürgen K. Willmann
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Photoacoustic Imaging ◽  
Transgenic Mouse Model ◽  
Cancer Development ◽  
Breast Cancer Development

scholarly journals The Effects of Adipocytes on the Regulation of Breast Cancer in the Tumor Microenvironment: An Update

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 857 ◽  
Author(s):  
Chu ◽  
Phuong ◽  
Tien ◽  
Tran ◽  
Nguyen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Tumor Therapy ◽  
Cancer Development ◽  
Systemic Review ◽  
Breast Cancer Development ◽  
Invasion And Migration ◽  
Metabolic Substrates

Obesity is a global pandemic and it is well evident that obesity is associated with the development of many disorders including many cancer types. Breast cancer is one of that associated with a high mortality rate. Adipocytes, a major cellular component in adipose tissue, are dysfunctional during obesity and also known to promote breast cancer development both in vitro and in vivo. Dysfunctional adipocytes can release metabolic substrates, adipokines, and cytokines, which promote proliferation, progression, invasion, and migration of breast cancer cells. The secretion of adipocytes can alter gene expression profile, induce inflammation and hypoxia, as well as inhibit apoptosis. It is known that excessive free fatty acids, cholesterol, triglycerides, hormones, leptin, interleukins, and chemokines upregulate breast cancer development. Interestingly, adiponectin is the only adipokine that has anti-tumor properties. Moreover, adipocytes are also related to chemotherapeutic resistance, resulting in the poorer outcome of treatment and advanced stages in breast cancer. Evaluation of the adipocyte secretion levels in the circulation can be useful for prognosis and evaluation of the effectiveness of cancer therapy in the patients. Therefore, understanding about functions of adipocytes as well as obesity in breast cancer may reveal novel targets that support the development of new anti-tumor therapy. In this systemic review, we summarize and update the effects of secreted factors by adipocytes on the regulation of breast cancer in the tumor microenvironment.

scholarly journals Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses

2019 ◽  
Vol 60 (2) ◽  
pp. 807 ◽  
Author(s):  
Jurgen Sergeys ◽  
Isabelle Etienne ◽  
Inge Van Hove ◽  
Evy Lefevere ◽  
Ingeborg Stalmans ◽  
...  
Keyword(s):  
Mouse Model ◽  
Diabetic Mouse ◽  
In Vivo Characterization
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