Structure-Based Design of Molecules to Reactivate Tumor-Derived p53 Mutations

2006 ◽  
Author(s):  
Ronen Marmorstein
Keyword(s):  
P53 Mutations

Smoking correlates with the presence of p53 mutations in squamous cell carcinomas of the head and neck (SCCHN)

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Mutations

Clinical importance of gallstones and p53 mutations in careinogenesis for gallbladder carcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A386-A386
Author(s):  
K HANADA ◽  
F HINO ◽  
H AMANO ◽  
H OOE ◽  
A HIRAMATSU ◽  
...  
Keyword(s):  
Gallbladder Carcinoma ◽  
Clinical Importance ◽  
P53 Mutations

p53 Mutations in Hairless SKH-hr1 Mouse Skin Tumors Induced by a Solar Simulator

1998 ◽  
Vol 67 (2) ◽  
pp. 227 ◽  
Author(s):  
Honnavara N. Ananthaswamy ◽  
Anny Fourtanier ◽  
Randall L. Evans ◽  
Sylvie Tison ◽  
Chantal Medaisko ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Skin Tumors ◽  
P53 Mutations ◽  
Solar Simulator

scholarly journals MDM2 Amplified Sarcomas: A Literature Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 496
Author(s):  
Raf Sciot
Keyword(s):  
Suppressor Gene ◽  
Negative Regulator ◽  
Low Grade ◽  
P53 Mutations ◽  
Lipomatous Tumor ◽  
Double Minute ◽  
Genetic Features ◽  
Murine Double Minute ◽  
Well Differentiated ◽  
Mdm2 Amplification

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.

p53 mutations in esophageal tumors from high-incidence areas of China

1995 ◽  
Vol 61 (5) ◽  
pp. 611-614 ◽  
Author(s):  
Yuan-Yuan Liang ◽  
Asuncion Estève ◽  
Ghyslaine Martel-Planche ◽  
Satoru Takahashi ◽  
Shih-Hsin Lu ◽  
...  
Keyword(s):  
P53 Mutations ◽  
High Incidence ◽  
Esophageal Tumors

283 P53 Mutations in Arylaminc- and Smoking-induced Human Bladder Cancer

Epidemiology ◽  
1995 ◽  
Vol 6 (2) ◽  
pp. S54
Author(s):  
J A Taylor ◽  
E Liu ◽  
M He ◽  
Y Li ◽  
T J Mason ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Human Bladder Cancer ◽  
P53 Mutations ◽  
Human Bladder
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