The Role of Tumor Metastases Suppressor Gene, Drg-1, in Breast Cancer

2006 ◽  
Author(s):  
Kounosuke Watabe
Keyword(s):  
Breast Cancer ◽  
Suppressor Gene ◽  
Tumor Metastases

scholarly journals ROLE OF TUMOUR SUPPRESSOR GENE P53 IN TRIPLE NEGATIVE BREAST CANCER

2017 ◽  
Vol 5 (4.2) ◽  
pp. 4585-4589
Author(s):  
Priya S Patil ◽  
◽  
Jaydeep N Pol ◽  
Ashalata D Patil ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

scholarly journals Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer

2021 ◽  
Author(s):  
Khulood M. Al-Khater ◽  
Sarah Almofty ◽  
Vijaya Ravinayagam ◽  
Noor Alrushaid ◽  
Suriya Rehman
Keyword(s):  
Breast Cancer ◽  
Suppressor Gene ◽  
Diagnosis And Prognosis

scholarly journals Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression

Oncogene ◽  
2004 ◽  
Vol 23 (33) ◽  
pp. 5675-5681 ◽  
Author(s):  
Sucharita Bandyopadhyay ◽  
Sudha K Pai ◽  
Shigeru Hirota ◽  
Sadahiro Hosobe ◽  
Yukio Takano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Tumor Metastasis ◽  
Suppressor Gene ◽  
Breast Cancer Progression ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

687 The role of WWOX, a tumour suppressor gene in breast cancer - a microarray study of MDA-MB-231 cell line

2010 ◽  
Vol 8 (5) ◽  
pp. 173
Author(s):  
K. Seta ◽  
M. Nowakowska ◽  
U. Lewandowska ◽  
E. Pluciennik ◽  
M. Zelazowski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Microarray Study

scholarly journals LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer

2021 ◽  
Author(s):  
YANG FAN ◽  
Lv shixu
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Flow Cytometric Analysis ◽  
Public Health Problem ◽  
Suppressor Gene ◽  
Potential Effect ◽  
Global Public Health

Abstract Background: Breast cancer is a leading global public health problem. In our previous study, we identified that lncRNA EPB41L4A antisense RNA 1 (EPB41L4A-AS1) was significantly downregulated in breast cancer. However, the functional role of EPB41L4A-AS1 in breast cancer has not been clarified. Here, we further confirmed the expression and biological function of EPB41L4A-AS1 in breast cancer. Methods: To demonstrate the role of EPB41L4A-AS1 in breast cancer, we transfected breast cancer lines with pcDNA3.1-EPB41L4A-AS1 expression vector to induce ectopic overexpression of EPB41L4A-AS1. Then, to explore the role of EPB41L4A-AS1 overexpression in breast cancer cell growth, cell cycle, apoptosis, invasion and migration capacity, we performed CCK-8 assay, colony formation assay, flow cytometry analysis, wound recovery and transwell assay, respectively. We also constructed a co-expression network to explore the potential effect mechanism of EPB41L4A-AS1. Results: Our research showed EPB41L4A-AS1 expression was significantly lower in tumor tissues than in adjacent non-cancerous tissues. overexpression of EPB41L4A-AS1 significantly reduced the proliferation of breast cancer cells. Flow cytometric analysis showed that forced expression of EPB41L4A-AS1 significantly increased the apoptosis rate of breast cancer cells. In addition, we found that upregulated EPB41L4A-AS1 significantly inhibited the migration and invasive ability of breast cancer. Functional analysis of co-expressed mRNAs suggested that EPB41L4A-AS1 may be involved in ribosomal, cell cycle, spliceosomal and p53 signaling pathways. Conclusions: Our findings suggest that EPB41L4A-AS1 is a tumor suppressor gene in breast cancer.

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